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Effects of LLLT on MRONJ-like mouse model. A The study's experimental protocols are depicted in this diagram. B Representative intraoral photos. (Ctrl: non-drug treatment group; Zol: treated with Zol group; Zol + LLLT: treated with Zol and LLLT group). Green dotted lines represent unhealed gingiva. C MicroCT reconstructed <t>3D</t> images of tooth sockets. Green dotted lines represent tooth sockets. D , E Quantification <t>of</t> <t>BMD</t> and BV/TV in each group. F H&E staining shows tooth extraction sockets-wound healing in each group. Black dotted boxes represent magnified boxed regions. Green dotted lines represent unhealed gingiva. Green dot lines represent necrotic bones. Scale bar = 200 μm (upper), scale bar = 100 μm (lower). G H&E staining shows the human gingiva of healthy and MRONJ patients. Black dotted boxes represent magnified boxed regions. Black arrows represent inflammatory cells. Scale bar = 200 μm (upper), scale bar = 50 μm (lower). H Masson’s trichrome staining shows tooth extraction sockets-wound healing in each group. Yellow dotted boxes represent magnified boxed regions. Scale bar = 200 μm (upper), scale bar = 100 μm (lower). I Masson’s trichrome staining shows collagen arrangement in human gingiva tissues. Yellow dotted boxes represent magnified boxed regions. Scale bar = 200 μm (upper), scale bar = 100 μm (lower). (* p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001)
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Effects of LLLT on MRONJ-like mouse model. A The study's experimental protocols are depicted in this diagram. B Representative intraoral photos. (Ctrl: non-drug treatment group; Zol: treated with Zol group; Zol + LLLT: treated with Zol and LLLT group). Green dotted lines represent unhealed gingiva. C MicroCT reconstructed <t>3D</t> images of tooth sockets. Green dotted lines represent tooth sockets. D , E Quantification <t>of</t> <t>BMD</t> and BV/TV in each group. F H&E staining shows tooth extraction sockets-wound healing in each group. Black dotted boxes represent magnified boxed regions. Green dotted lines represent unhealed gingiva. Green dot lines represent necrotic bones. Scale bar = 200 μm (upper), scale bar = 100 μm (lower). G H&E staining shows the human gingiva of healthy and MRONJ patients. Black dotted boxes represent magnified boxed regions. Black arrows represent inflammatory cells. Scale bar = 200 μm (upper), scale bar = 50 μm (lower). H Masson’s trichrome staining shows tooth extraction sockets-wound healing in each group. Yellow dotted boxes represent magnified boxed regions. Scale bar = 200 μm (upper), scale bar = 100 μm (lower). I Masson’s trichrome staining shows collagen arrangement in human gingiva tissues. Yellow dotted boxes represent magnified boxed regions. Scale bar = 200 μm (upper), scale bar = 100 μm (lower). (* p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001)
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Effects of LLLT on MRONJ-like mouse model. A The study's experimental protocols are depicted in this diagram. B Representative intraoral photos. (Ctrl: non-drug treatment group; Zol: treated with Zol group; Zol + LLLT: treated with Zol and LLLT group). Green dotted lines represent unhealed gingiva. C MicroCT reconstructed <t>3D</t> images of tooth sockets. Green dotted lines represent tooth sockets. D , E Quantification <t>of</t> <t>BMD</t> and BV/TV in each group. F H&E staining shows tooth extraction sockets-wound healing in each group. Black dotted boxes represent magnified boxed regions. Green dotted lines represent unhealed gingiva. Green dot lines represent necrotic bones. Scale bar = 200 μm (upper), scale bar = 100 μm (lower). G H&E staining shows the human gingiva of healthy and MRONJ patients. Black dotted boxes represent magnified boxed regions. Black arrows represent inflammatory cells. Scale bar = 200 μm (upper), scale bar = 50 μm (lower). H Masson’s trichrome staining shows tooth extraction sockets-wound healing in each group. Yellow dotted boxes represent magnified boxed regions. Scale bar = 200 μm (upper), scale bar = 100 μm (lower). I Masson’s trichrome staining shows collagen arrangement in human gingiva tissues. Yellow dotted boxes represent magnified boxed regions. Scale bar = 200 μm (upper), scale bar = 100 μm (lower). (* p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001)
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Effects of LLLT on MRONJ-like mouse model. A The study's experimental protocols are depicted in this diagram. B Representative intraoral photos. (Ctrl: non-drug treatment group; Zol: treated with Zol group; Zol + LLLT: treated with Zol and LLLT group). Green dotted lines represent unhealed gingiva. C MicroCT reconstructed <t>3D</t> images of tooth sockets. Green dotted lines represent tooth sockets. D , E Quantification <t>of</t> <t>BMD</t> and BV/TV in each group. F H&E staining shows tooth extraction sockets-wound healing in each group. Black dotted boxes represent magnified boxed regions. Green dotted lines represent unhealed gingiva. Green dot lines represent necrotic bones. Scale bar = 200 μm (upper), scale bar = 100 μm (lower). G H&E staining shows the human gingiva of healthy and MRONJ patients. Black dotted boxes represent magnified boxed regions. Black arrows represent inflammatory cells. Scale bar = 200 μm (upper), scale bar = 50 μm (lower). H Masson’s trichrome staining shows tooth extraction sockets-wound healing in each group. Yellow dotted boxes represent magnified boxed regions. Scale bar = 200 μm (upper), scale bar = 100 μm (lower). I Masson’s trichrome staining shows collagen arrangement in human gingiva tissues. Yellow dotted boxes represent magnified boxed regions. Scale bar = 200 μm (upper), scale bar = 100 μm (lower). (* p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001)
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Effects of LLLT on MRONJ-like mouse model. A The study's experimental protocols are depicted in this diagram. B Representative intraoral photos. (Ctrl: non-drug treatment group; Zol: treated with Zol group; Zol + LLLT: treated with Zol and LLLT group). Green dotted lines represent unhealed gingiva. C MicroCT reconstructed <t>3D</t> images of tooth sockets. Green dotted lines represent tooth sockets. D , E Quantification <t>of</t> <t>BMD</t> and BV/TV in each group. F H&E staining shows tooth extraction sockets-wound healing in each group. Black dotted boxes represent magnified boxed regions. Green dotted lines represent unhealed gingiva. Green dot lines represent necrotic bones. Scale bar = 200 μm (upper), scale bar = 100 μm (lower). G H&E staining shows the human gingiva of healthy and MRONJ patients. Black dotted boxes represent magnified boxed regions. Black arrows represent inflammatory cells. Scale bar = 200 μm (upper), scale bar = 50 μm (lower). H Masson’s trichrome staining shows tooth extraction sockets-wound healing in each group. Yellow dotted boxes represent magnified boxed regions. Scale bar = 200 μm (upper), scale bar = 100 μm (lower). I Masson’s trichrome staining shows collagen arrangement in human gingiva tissues. Yellow dotted boxes represent magnified boxed regions. Scale bar = 200 μm (upper), scale bar = 100 μm (lower). (* p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001)
3d Bone Morphometric Software Tri/3d Bon, supplied by Ratoc Systems Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/bone+morphometric+software/pm27454457-60-17-22?v=Ratoc+Systems+Inc
Average 90 stars, based on 1 article reviews
3d bone morphometric software tri/3d-bon - by Bioz Stars, 2026-07
90/100 stars
  Buy from Supplier

Image Search Results


Effects of LLLT on MRONJ-like mouse model. A The study's experimental protocols are depicted in this diagram. B Representative intraoral photos. (Ctrl: non-drug treatment group; Zol: treated with Zol group; Zol + LLLT: treated with Zol and LLLT group). Green dotted lines represent unhealed gingiva. C MicroCT reconstructed 3D images of tooth sockets. Green dotted lines represent tooth sockets. D , E Quantification of BMD and BV/TV in each group. F H&E staining shows tooth extraction sockets-wound healing in each group. Black dotted boxes represent magnified boxed regions. Green dotted lines represent unhealed gingiva. Green dot lines represent necrotic bones. Scale bar = 200 μm (upper), scale bar = 100 μm (lower). G H&E staining shows the human gingiva of healthy and MRONJ patients. Black dotted boxes represent magnified boxed regions. Black arrows represent inflammatory cells. Scale bar = 200 μm (upper), scale bar = 50 μm (lower). H Masson’s trichrome staining shows tooth extraction sockets-wound healing in each group. Yellow dotted boxes represent magnified boxed regions. Scale bar = 200 μm (upper), scale bar = 100 μm (lower). I Masson’s trichrome staining shows collagen arrangement in human gingiva tissues. Yellow dotted boxes represent magnified boxed regions. Scale bar = 200 μm (upper), scale bar = 100 μm (lower). (* p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001)

Journal: BMC Oral Health

Article Title: Low-level laser therapy prevents medication-related osteonecrosis of the jaw-like lesions via IL-1RA-mediated primary gingival wound healing

doi: 10.1186/s12903-022-02678-1

Figure Lengend Snippet: Effects of LLLT on MRONJ-like mouse model. A The study's experimental protocols are depicted in this diagram. B Representative intraoral photos. (Ctrl: non-drug treatment group; Zol: treated with Zol group; Zol + LLLT: treated with Zol and LLLT group). Green dotted lines represent unhealed gingiva. C MicroCT reconstructed 3D images of tooth sockets. Green dotted lines represent tooth sockets. D , E Quantification of BMD and BV/TV in each group. F H&E staining shows tooth extraction sockets-wound healing in each group. Black dotted boxes represent magnified boxed regions. Green dotted lines represent unhealed gingiva. Green dot lines represent necrotic bones. Scale bar = 200 μm (upper), scale bar = 100 μm (lower). G H&E staining shows the human gingiva of healthy and MRONJ patients. Black dotted boxes represent magnified boxed regions. Black arrows represent inflammatory cells. Scale bar = 200 μm (upper), scale bar = 50 μm (lower). H Masson’s trichrome staining shows tooth extraction sockets-wound healing in each group. Yellow dotted boxes represent magnified boxed regions. Scale bar = 200 μm (upper), scale bar = 100 μm (lower). I Masson’s trichrome staining shows collagen arrangement in human gingiva tissues. Yellow dotted boxes represent magnified boxed regions. Scale bar = 200 μm (upper), scale bar = 100 μm (lower). (* p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001)

Article Snippet: The area of interest was chosen, and bone mineral density (BMD) and bone volume/total volume (BV/TV) were quantified by three-dimensional (3D) bone morphometric software (SIEMENS, Munich, Germany).

Techniques: Staining

Application of IL-1RA NAb impairs the capacity of LLLT to promote gingival wound healing. A The study's experimental protocols are depicted in this diagram. B Representative intraoral photos. (Ctrl: non-drug treatment, but treated with negative control antibodies group; Zol: treated with Zol and negative control antibodies group; Zol + LLLT: treated with Zol, LLLT, and negative control antibodies group; Zol + LLLT + IL-1RA: treated with Zol, LLLT, and IL-1RA NAb group). Green dotted lines represent unhealed gingiva. C MicroCT reconstructed 3D images of tooth sockets. Green dotted lines represent tooth sockets. D , E Quantification of BMD and BV/TV in each group. F H&E staining shows tooth extraction sockets-wound healing in each group. Black dotted boxes represent magnified boxed regions. Green dotted lines represent unhealed gingiva. Scale bar = 200 μm (upper), scale bar = 100 μm (lower). G , H Images of IL-1β and TNF-α IHC staining of the mouse gingival wound. Scale bar = 100 μm. (* p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001)

Journal: BMC Oral Health

Article Title: Low-level laser therapy prevents medication-related osteonecrosis of the jaw-like lesions via IL-1RA-mediated primary gingival wound healing

doi: 10.1186/s12903-022-02678-1

Figure Lengend Snippet: Application of IL-1RA NAb impairs the capacity of LLLT to promote gingival wound healing. A The study's experimental protocols are depicted in this diagram. B Representative intraoral photos. (Ctrl: non-drug treatment, but treated with negative control antibodies group; Zol: treated with Zol and negative control antibodies group; Zol + LLLT: treated with Zol, LLLT, and negative control antibodies group; Zol + LLLT + IL-1RA: treated with Zol, LLLT, and IL-1RA NAb group). Green dotted lines represent unhealed gingiva. C MicroCT reconstructed 3D images of tooth sockets. Green dotted lines represent tooth sockets. D , E Quantification of BMD and BV/TV in each group. F H&E staining shows tooth extraction sockets-wound healing in each group. Black dotted boxes represent magnified boxed regions. Green dotted lines represent unhealed gingiva. Scale bar = 200 μm (upper), scale bar = 100 μm (lower). G , H Images of IL-1β and TNF-α IHC staining of the mouse gingival wound. Scale bar = 100 μm. (* p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001)

Article Snippet: The area of interest was chosen, and bone mineral density (BMD) and bone volume/total volume (BV/TV) were quantified by three-dimensional (3D) bone morphometric software (SIEMENS, Munich, Germany).

Techniques: Negative Control, Staining, Immunohistochemistry