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Fig. 1. Chemical properties of Compound A (A) Structural information of Compound A (B) Dose-dependent inhibition of Compound A in LPA-induced 35S-GTPγS binding to the cell membrane. (C) Dose-dependent inhibition of Compound A in Ca2+ influx. (D) Specific binding evaluation of Compound A on GPCR in β-arrestin assay. <t>LPA1,</t> 2, 3, 5: lysophosphatidic acid receptor 1, 2, 3, 5, S1P1, 4: sphingosine-1-phosphate receptor 1, 4.
Lpa1 Antagonist9, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Fig. 1. Chemical properties of Compound A (A) Structural information of Compound A (B) Dose-dependent inhibition of Compound A in LPA-induced 35S-GTPγS binding to the cell membrane. (C) Dose-dependent inhibition of Compound A in Ca2+ influx. (D) Specific binding evaluation of Compound A on GPCR in β-arrestin assay. <t>LPA1,</t> 2, 3, 5: lysophosphatidic acid receptor 1, 2, 3, 5, S1P1, 4: sphingosine-1-phosphate receptor 1, 4.
Bms, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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bms 986020 bms  (MedChemExpress)
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Fig. 1. Chemical properties of Compound A (A) Structural information of Compound A (B) Dose-dependent inhibition of Compound A in LPA-induced 35S-GTPγS binding to the cell membrane. (C) Dose-dependent inhibition of Compound A in Ca2+ influx. (D) Specific binding evaluation of Compound A on GPCR in β-arrestin assay. <t>LPA1,</t> 2, 3, 5: lysophosphatidic acid receptor 1, 2, 3, 5, S1P1, 4: sphingosine-1-phosphate receptor 1, 4.
Bms 986020 Bms, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Fig. 1. Chemical properties of Compound A (A) Structural information of Compound A (B) Dose-dependent inhibition of Compound A in LPA-induced 35S-GTPγS binding to the cell membrane. (C) Dose-dependent inhibition of Compound A in Ca2+ influx. (D) Specific binding evaluation of Compound A on GPCR in β-arrestin assay. <t>LPA1,</t> 2, 3, 5: lysophosphatidic acid receptor 1, 2, 3, 5, S1P1, 4: sphingosine-1-phosphate receptor 1, 4.
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bms-986020  (Bristol Myers)
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Fig. 1. Chemical properties of Compound A (A) Structural information of Compound A (B) Dose-dependent inhibition of Compound A in LPA-induced 35S-GTPγS binding to the cell membrane. (C) Dose-dependent inhibition of Compound A in Ca2+ influx. (D) Specific binding evaluation of Compound A on GPCR in β-arrestin assay. <t>LPA1,</t> 2, 3, 5: lysophosphatidic acid receptor 1, 2, 3, 5, S1P1, 4: sphingosine-1-phosphate receptor 1, 4.
Bms 986020, supplied by Bristol Myers, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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bms986020  (MedChemExpress)
91
MedChemExpress bms986020
Fig. 1. Chemical properties of Compound A (A) Structural information of Compound A (B) Dose-dependent inhibition of Compound A in LPA-induced 35S-GTPγS binding to the cell membrane. (C) Dose-dependent inhibition of Compound A in Ca2+ influx. (D) Specific binding evaluation of Compound A on GPCR in β-arrestin assay. <t>LPA1,</t> 2, 3, 5: lysophosphatidic acid receptor 1, 2, 3, 5, S1P1, 4: sphingosine-1-phosphate receptor 1, 4.
Bms986020, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/bms986020/product/MedChemExpress
Average 91 stars, based on 1 article reviews
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Fig. 1. Chemical properties of Compound A (A) Structural information of Compound A (B) Dose-dependent inhibition of Compound A in LPA-induced 35S-GTPγS binding to the cell membrane. (C) Dose-dependent inhibition of Compound A in Ca2+ influx. (D) Specific binding evaluation of Compound A on GPCR in β-arrestin assay. LPA1, 2, 3, 5: lysophosphatidic acid receptor 1, 2, 3, 5, S1P1, 4: sphingosine-1-phosphate receptor 1, 4.

Journal: Journal of pharmacological sciences

Article Title: A novel lysophosphatidic acid receptor 1 antagonist with high brain penetrability has a curative effect in the empathic pain-related fibromyalgia model.

doi: 10.1016/j.jphs.2025.03.012

Figure Lengend Snippet: Fig. 1. Chemical properties of Compound A (A) Structural information of Compound A (B) Dose-dependent inhibition of Compound A in LPA-induced 35S-GTPγS binding to the cell membrane. (C) Dose-dependent inhibition of Compound A in Ca2+ influx. (D) Specific binding evaluation of Compound A on GPCR in β-arrestin assay. LPA1, 2, 3, 5: lysophosphatidic acid receptor 1, 2, 3, 5, S1P1, 4: sphingosine-1-phosphate receptor 1, 4.

Article Snippet: BMS-986020, an LPA1 antagonist9 was purchased from MCE (Monmouth Junction, NJ, USA).

Techniques: Inhibition, Binding Assay, Membrane, Beta-Arrestin Assay