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Journal: Pharmaceutics
Article Title: Solitary and Synergistic Effects of Different Hydrophilic and Hydrophobic Phospholipid Moieties on Rat Behaviors
doi: 10.3390/pharmaceutics16060762
Figure Lengend Snippet: Liposomes containing cholesterol cross the BBB model more than liposomes containing PEG. Fluorescence of DiIC 18 was barely detected in the BBB model within 3 h after adding liposomes to the blood side; however, liposomes with cholesterol (Cho-lip, n = 4) tended to pass through the BBB more than liposomes with PEG (PEG-lip, n = 4) at 24 h ( p = 0.082) and showed significantly higher permeability at 48 h compared with PEG-lip ( p = 0.0067). Values are presented as the mean ± standard error.
Article Snippet: Permeability of the BBB to liposomes was assessed using a
Techniques: Liposomes, Fluorescence, Permeability