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Study design. After a screening visit (red) to assess eligibility and baseline parameters, participants underwent two experimental visits (blue) in a randomized, double-blind, cross-over design. Each visit was preceded by ≥48-hour headache- and medication-free period. Participants received intravenous <t>atosiban</t> or placebo, followed by the alternate treatment at the second visit. During a 180-minute infusion, headache characteristics, vital signs, side effects (every 10 minutes), superficial temporal artery (STA) diameter, middle cerebral artery (MCA) blood flow velocity (every 30 minutes) were assessed. After discharge, participants completed hourly headache diaries for 21 hours. Created with BioRender.com
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atosiban ggaucaaucauggcaa c6 nh alexa647  (MedChemExpress)
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Study design. After a screening visit (red) to assess eligibility and baseline parameters, participants underwent two experimental visits (blue) in a randomized, double-blind, cross-over design. Each visit was preceded by ≥48-hour headache- and medication-free period. Participants received intravenous <t>atosiban</t> or placebo, followed by the alternate treatment at the second visit. During a 180-minute infusion, headache characteristics, vital signs, side effects (every 10 minutes), superficial temporal artery (STA) diameter, middle cerebral artery (MCA) blood flow velocity (every 30 minutes) were assessed. After discharge, participants completed hourly headache diaries for 21 hours. Created with BioRender.com
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atosiban acetate injection  (Zhonghe Headway)
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Study design. After a screening visit (red) to assess eligibility and baseline parameters, participants underwent two experimental visits (blue) in a randomized, double-blind, cross-over design. Each visit was preceded by ≥48-hour headache- and medication-free period. Participants received intravenous <t>atosiban</t> or placebo, followed by the alternate treatment at the second visit. During a 180-minute infusion, headache characteristics, vital signs, side effects (every 10 minutes), superficial temporal artery (STA) diameter, middle cerebral artery (MCA) blood flow velocity (every 30 minutes) were assessed. After discharge, participants completed hourly headache diaries for 21 hours. Created with BioRender.com
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atosiban  (MedChemExpress)
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MedChemExpress atosiban
Study design. After a screening visit (red) to assess eligibility and baseline parameters, participants underwent two experimental visits (blue) in a randomized, double-blind, cross-over design. Each visit was preceded by ≥48-hour headache- and medication-free period. Participants received intravenous <t>atosiban</t> or placebo, followed by the alternate treatment at the second visit. During a 180-minute infusion, headache characteristics, vital signs, side effects (every 10 minutes), superficial temporal artery (STA) diameter, middle cerebral artery (MCA) blood flow velocity (every 30 minutes) were assessed. After discharge, participants completed hourly headache diaries for 21 hours. Created with BioRender.com
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Study design. After a screening visit (red) to assess eligibility and baseline parameters, participants underwent two experimental visits (blue) in a randomized, double-blind, cross-over design. Each visit was preceded by ≥48-hour headache- and medication-free period. Participants received intravenous atosiban or placebo, followed by the alternate treatment at the second visit. During a 180-minute infusion, headache characteristics, vital signs, side effects (every 10 minutes), superficial temporal artery (STA) diameter, middle cerebral artery (MCA) blood flow velocity (every 30 minutes) were assessed. After discharge, participants completed hourly headache diaries for 21 hours. Created with BioRender.com

Journal: The Journal of Headache and Pain

Article Title: Oxytocin receptor antagonism in migraine: a randomized, double-blind, placebo-controlled provocation study

doi: 10.1186/s10194-026-02297-z

Figure Lengend Snippet: Study design. After a screening visit (red) to assess eligibility and baseline parameters, participants underwent two experimental visits (blue) in a randomized, double-blind, cross-over design. Each visit was preceded by ≥48-hour headache- and medication-free period. Participants received intravenous atosiban or placebo, followed by the alternate treatment at the second visit. During a 180-minute infusion, headache characteristics, vital signs, side effects (every 10 minutes), superficial temporal artery (STA) diameter, middle cerebral artery (MCA) blood flow velocity (every 30 minutes) were assessed. After discharge, participants completed hourly headache diaries for 21 hours. Created with BioRender.com

Article Snippet: We conducted a single-center, double-blind, randomized, placebo-controlled human provocation study in a cross-over design using the OTR-antagonist atosiban (Tracotile ® ; Ferring Pharmaceuticals, Saint-Prex, Switzerland) as the provocation substance (Fig. ).

Techniques:

Pain intensity scores after atosiban or placebo administration. Median headache intensity score (thick lines) and individual participant headache scroes (thin lines) on the numerical rating scale (NRS) following atosiban (blue) or placebo (orange) in women with migraine (left), female control group (middle) and men with migraine (right)

Journal: The Journal of Headache and Pain

Article Title: Oxytocin receptor antagonism in migraine: a randomized, double-blind, placebo-controlled provocation study

doi: 10.1186/s10194-026-02297-z

Figure Lengend Snippet: Pain intensity scores after atosiban or placebo administration. Median headache intensity score (thick lines) and individual participant headache scroes (thin lines) on the numerical rating scale (NRS) following atosiban (blue) or placebo (orange) in women with migraine (left), female control group (middle) and men with migraine (right)

Article Snippet: We conducted a single-center, double-blind, randomized, placebo-controlled human provocation study in a cross-over design using the OTR-antagonist atosiban (Tracotile ® ; Ferring Pharmaceuticals, Saint-Prex, Switzerland) as the provocation substance (Fig. ).

Techniques: Control

Vascular parameters after atosiban or placebo administration. Mean heart rate ( A ), mean arterial blood pressure ( B ), mean blood velocity of the middle cerebral artery (MCA) ( C ) and mean diameter of the superficial temporal artery (STA) ( D ) during the 180 min after atosiban (blue) or placebo (orange) administration in women with migraine (left), female control group (middle) and men with migraine (right)

Journal: The Journal of Headache and Pain

Article Title: Oxytocin receptor antagonism in migraine: a randomized, double-blind, placebo-controlled provocation study

doi: 10.1186/s10194-026-02297-z

Figure Lengend Snippet: Vascular parameters after atosiban or placebo administration. Mean heart rate ( A ), mean arterial blood pressure ( B ), mean blood velocity of the middle cerebral artery (MCA) ( C ) and mean diameter of the superficial temporal artery (STA) ( D ) during the 180 min after atosiban (blue) or placebo (orange) administration in women with migraine (left), female control group (middle) and men with migraine (right)

Article Snippet: We conducted a single-center, double-blind, randomized, placebo-controlled human provocation study in a cross-over design using the OTR-antagonist atosiban (Tracotile ® ; Ferring Pharmaceuticals, Saint-Prex, Switzerland) as the provocation substance (Fig. ).

Techniques: Control