Journal: Antimicrobial Agents and Chemotherapy

Article Title: Pharmacokinetic and pharmacodynamic modeling of anti-plasmodial drugs mefloquine plus artesunate: insights on translational application

doi: 10.1128/aac.01717-25

Figure Lengend Snippet: Prediction-corrected visual predictive checks (pcVPCs) for the final pharmacokinetic models of ( a ) mefloquine and ( b ) artesunate. Closed circles represent the prediction-corrected observed plasma concentrations. The black dashed lines indicate the median and 90% prediction interval (PI) of the observed data, overlaid on the model-simulated prediction intervals.

Article Snippet: Mefloquine hydrochloride (MQ) was purchased from Sigma-Aldrich, and Artesunate was purchased from TCI Chemicals.

Techniques: Clinical Proteomics

Journal: Antimicrobial Agents and Chemotherapy

Article Title: Pharmacokinetic and pharmacodynamic modeling of anti-plasmodial drugs mefloquine plus artesunate: insights on translational application

doi: 10.1128/aac.01717-25

Figure Lengend Snippet: Simulated effect of mefloquine (left panel) and artesunate (right panel) on parasitemia reduction following a single dose of ASMQ combination therapy in mice. The black line represents the median predicted response, and the shaded area indicates the 5th to 95th percentile prediction interval.

Article Snippet: Mefloquine hydrochloride (MQ) was purchased from Sigma-Aldrich, and Artesunate was purchased from TCI Chemicals.

Techniques:

Journal: Antimicrobial Agents and Chemotherapy

Article Title: Pharmacokinetic and pharmacodynamic modeling of anti-plasmodial drugs mefloquine plus artesunate: insights on translational application

doi: 10.1128/aac.01717-25

Figure Lengend Snippet: Simulated parasitemia percentage profiles generated using “true” pharmacokinetic parameters of mefloquine + artesunate ( a ) and artesuane alone ( b ). A total of 1,000 simulations were performed; the black line represents the median prediction, and the shaded area indicates the 5th to 95th percentile prediction interval.

Article Snippet: Mefloquine hydrochloride (MQ) was purchased from Sigma-Aldrich, and Artesunate was purchased from TCI Chemicals.

Techniques: Generated

Journal: Advanced Science

Article Title: Artesunate Ameliorates APAP‐induced Liver Injury by Promoting NEDD4L‐Mediated Ubiquitination and Degradation of TXNIP

doi: 10.1002/advs.202521818

Figure Lengend Snippet: Artesunate (ART) alleviates APAP‐induced liver injury. (A) Schematic diagram of the experimental procedure. The mice were fasted for 16 h, then intraperitoneally injected with 400 mg/kg APAP, and 1 h later, they were injected with ART. The samples were collected 24 h later (n = 8). (B,C) The levels of ALT and AST in the serum of the mice (n = 8). (D–F) The levels of TNF‐α, IL‐6, and IL‐1β in the serum of the mice (n = 8). (G) LDH levels in the serum of the mice (n = 8). (H) Representative images of H&E and TUNEL staining of the livers of the mice. (I) Quantification of necrotic area in the livers of the mice (n = 8). (J) Schematic diagram of the experimental procedure. The mice were fasted for 16 h, then intraperitoneally injected with 400 mg/kg APAP, and 10 h later, they were injected with ART. The samples were collected 24 h later (n = 8). (K,L) The levels of ALT and AST in the serum of the mice (n = 8). (M) Representative images of HE‐stained livers from the mice. (N) Quantification of the necrotic area in the livers of the mice (n = 8). (O) LDH levels in the serum of the mice (n = 8). (P) Schematic diagram of the experimental procedure. The mice were fasted for 16 h, then intraperitoneally injected with 650 mg/kg APAP, and 10 h later, they were injected with ART (n = 10). (Q) Survival curve of mice treated with ART after the administration of a lethal dose of APAP (n = 10). Data are presented as mean ± SEM. ** P < 0.01.

Article Snippet: Artesunate (S24000;98%/ B20992 ) and Acetaminophen ( S31044 ;99%, AR/ B20338 ) were purchased from Shanghai Yuanye Bio‐Technology Co., Ltd. (Shanghai, China).

Techniques: Injection, TUNEL Assay, Staining