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Apoa1 Mimetics, supplied by Mimetics, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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apoa1 mimetics m2 m1 macrophage repolarization  (Mimetics)
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apoa1 mimetic peptide 4 f  (Dawley Inc)
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Mechanism by which <t>ApoA1</t> Inhibits Vascular Endothelial Inflammation. Lipid-free ApoA1 protein or its mimetic peptides interact with the ABCA1 receptor (a 12-transmembrane protein located in non-raft membrane domains, which has poor cholesterol) on macrophages. Concurrently, ApoA1 within (r)HDL interacts with the scavenger receptor SR-B1 (located in cholesterol-rich lipid raft domains). Both interactions promote the efflux of free cholesterol from macrophages to ApoA1 (indicated by a yellow straight arrow). Notably, the cholesterol efflux regulatory protein AIBP (ApoA1-Binding Protein) enhances the binding of ApoA1 to the ABCA1 receptor. Pathway ①: Inhibition of TLR4 consequently suppresses its downstream pro-inflammatory signaling pathways. Pathways ② and ③: Signaling pathways that inhibit inflammation, initiated respectively by the binding of ApoA1 to the ABCA1 receptor and HDL to the SR-B1 receptor. Pathway ④: Reconstituted HDL (rHDL) inhibits LPS-stimulated activation of the NLRP3 inflammasome. Created with BioGDP.com
Apoa1 Mimetic Peptide 4 F, supplied by Dawley Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/apoa1+mimetics/4+apoa1+f+mimetic+peptide/pmc12506352-15-0-11
Average 86 stars, based on 1 article reviews
apoa1 mimetic peptide 4 f - by Bioz Stars, 2026-10
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apoa1 mimetic peptide (22a)  (GenScript corporation)
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Mechanism by which <t>ApoA1</t> Inhibits Vascular Endothelial Inflammation. Lipid-free ApoA1 protein or its mimetic peptides interact with the ABCA1 receptor (a 12-transmembrane protein located in non-raft membrane domains, which has poor cholesterol) on macrophages. Concurrently, ApoA1 within (r)HDL interacts with the scavenger receptor SR-B1 (located in cholesterol-rich lipid raft domains). Both interactions promote the efflux of free cholesterol from macrophages to ApoA1 (indicated by a yellow straight arrow). Notably, the cholesterol efflux regulatory protein AIBP (ApoA1-Binding Protein) enhances the binding of ApoA1 to the ABCA1 receptor. Pathway ①: Inhibition of TLR4 consequently suppresses its downstream pro-inflammatory signaling pathways. Pathways ② and ③: Signaling pathways that inhibit inflammation, initiated respectively by the binding of ApoA1 to the ABCA1 receptor and HDL to the SR-B1 receptor. Pathway ④: Reconstituted HDL (rHDL) inhibits LPS-stimulated activation of the NLRP3 inflammasome. Created with BioGDP.com
Apoa1 Mimetic Peptide (22a), supplied by GenScript corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/apoa1+mimetics/apoa1+mimetic+peptide++22a+/us12257352-1434-0-27
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apoa1 mimetic peptide (22a) - by Bioz Stars, 2026-10
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apolipoprotein a1-mimetic peptide (apoa1, pvldlfrellnellealkqklk, pk-22)  (Shanghai Apeptide Co)
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Shanghai Apeptide Co apolipoprotein a1-mimetic peptide (apoa1, pvldlfrellnellealkqklk, pk-22)
Mechanism by which <t>ApoA1</t> Inhibits Vascular Endothelial Inflammation. Lipid-free ApoA1 protein or its mimetic peptides interact with the ABCA1 receptor (a 12-transmembrane protein located in non-raft membrane domains, which has poor cholesterol) on macrophages. Concurrently, ApoA1 within (r)HDL interacts with the scavenger receptor SR-B1 (located in cholesterol-rich lipid raft domains). Both interactions promote the efflux of free cholesterol from macrophages to ApoA1 (indicated by a yellow straight arrow). Notably, the cholesterol efflux regulatory protein AIBP (ApoA1-Binding Protein) enhances the binding of ApoA1 to the ABCA1 receptor. Pathway ①: Inhibition of TLR4 consequently suppresses its downstream pro-inflammatory signaling pathways. Pathways ② and ③: Signaling pathways that inhibit inflammation, initiated respectively by the binding of ApoA1 to the ABCA1 receptor and HDL to the SR-B1 receptor. Pathway ④: Reconstituted HDL (rHDL) inhibits LPS-stimulated activation of the NLRP3 inflammasome. Created with BioGDP.com
Apolipoprotein A1 Mimetic Peptide (Apoa1, Pvldlfrellnellealkqklk, Pk 22), supplied by Shanghai Apeptide Co, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/apoa1+mimetics/r4f++an+apoa1+mimetic+peptide++ac+faekfkeavkdyfakfwd+/pm40106687__nl4c06402_si_001-7-1-11
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Mechanism by which ApoA1 Inhibits Vascular Endothelial Inflammation. Lipid-free ApoA1 protein or its mimetic peptides interact with the ABCA1 receptor (a 12-transmembrane protein located in non-raft membrane domains, which has poor cholesterol) on macrophages. Concurrently, ApoA1 within (r)HDL interacts with the scavenger receptor SR-B1 (located in cholesterol-rich lipid raft domains). Both interactions promote the efflux of free cholesterol from macrophages to ApoA1 (indicated by a yellow straight arrow). Notably, the cholesterol efflux regulatory protein AIBP (ApoA1-Binding Protein) enhances the binding of ApoA1 to the ABCA1 receptor. Pathway ①: Inhibition of TLR4 consequently suppresses its downstream pro-inflammatory signaling pathways. Pathways ② and ③: Signaling pathways that inhibit inflammation, initiated respectively by the binding of ApoA1 to the ABCA1 receptor and HDL to the SR-B1 receptor. Pathway ④: Reconstituted HDL (rHDL) inhibits LPS-stimulated activation of the NLRP3 inflammasome. Created with BioGDP.com

Journal: Critical Care

Article Title: ApoA1/HDL and sepsis-associated vascular endothelial injury: a narrative review

doi: 10.1186/s13054-025-05668-1

Figure Lengend Snippet: Mechanism by which ApoA1 Inhibits Vascular Endothelial Inflammation. Lipid-free ApoA1 protein or its mimetic peptides interact with the ABCA1 receptor (a 12-transmembrane protein located in non-raft membrane domains, which has poor cholesterol) on macrophages. Concurrently, ApoA1 within (r)HDL interacts with the scavenger receptor SR-B1 (located in cholesterol-rich lipid raft domains). Both interactions promote the efflux of free cholesterol from macrophages to ApoA1 (indicated by a yellow straight arrow). Notably, the cholesterol efflux regulatory protein AIBP (ApoA1-Binding Protein) enhances the binding of ApoA1 to the ABCA1 receptor. Pathway ①: Inhibition of TLR4 consequently suppresses its downstream pro-inflammatory signaling pathways. Pathways ② and ③: Signaling pathways that inhibit inflammation, initiated respectively by the binding of ApoA1 to the ABCA1 receptor and HDL to the SR-B1 receptor. Pathway ④: Reconstituted HDL (rHDL) inhibits LPS-stimulated activation of the NLRP3 inflammasome. Created with BioGDP.com

Article Snippet: APOA1 mimetic peptide 4 F , In vivo , Sprague - Dawley rats , 10 mg/kg; i.p. , CLP , , IL-6↓;HDL↑; survival rate↑ , [ ] .

Techniques: Membrane, Binding Assay, Inhibition, Protein-Protein interactions, Activation Assay

ApoA1 maintains endothelial barrier integrity. Pathway ①: ApoA1 and ApoA1 mimetic peptides (such as D-4 F) inhibit EndMT in endothelial cells. Pathway ②: (r)HDL binds to the SR-B1 receptor, initiating signaling pathways that upregulate ANGPTL4 levels, thereby protecting the endothelial glycocalyx. Created with BioGDP.com

Journal: Critical Care

Article Title: ApoA1/HDL and sepsis-associated vascular endothelial injury: a narrative review

doi: 10.1186/s13054-025-05668-1

Figure Lengend Snippet: ApoA1 maintains endothelial barrier integrity. Pathway ①: ApoA1 and ApoA1 mimetic peptides (such as D-4 F) inhibit EndMT in endothelial cells. Pathway ②: (r)HDL binds to the SR-B1 receptor, initiating signaling pathways that upregulate ANGPTL4 levels, thereby protecting the endothelial glycocalyx. Created with BioGDP.com

Article Snippet: APOA1 mimetic peptide 4 F , In vivo , Sprague - Dawley rats , 10 mg/kg; i.p. , CLP , , IL-6↓;HDL↑; survival rate↑ , [ ] .

Techniques: Protein-Protein interactions

ApoA1 prevents vascular occlusion, thrombosis, and maintains vascular tone. Pathway ①: (r)HDL binds to the PDZK1 domain of SR-B1, leading to eNOS phosphorylation, producing NO to prevent microvascular occlusion and reducing vWF. Pathway ②: Lipid-free ApoA1 or (r)HDL binds to Ecto-F1-ATPase, activating the PI3Kβ/AKT signaling pathway. Pathway ③ and ④ upregulate COX-2 and PGI-2. Created with BioGDP.com

Journal: Critical Care

Article Title: ApoA1/HDL and sepsis-associated vascular endothelial injury: a narrative review

doi: 10.1186/s13054-025-05668-1

Figure Lengend Snippet: ApoA1 prevents vascular occlusion, thrombosis, and maintains vascular tone. Pathway ①: (r)HDL binds to the PDZK1 domain of SR-B1, leading to eNOS phosphorylation, producing NO to prevent microvascular occlusion and reducing vWF. Pathway ②: Lipid-free ApoA1 or (r)HDL binds to Ecto-F1-ATPase, activating the PI3Kβ/AKT signaling pathway. Pathway ③ and ④ upregulate COX-2 and PGI-2. Created with BioGDP.com

Article Snippet: APOA1 mimetic peptide 4 F , In vivo , Sprague - Dawley rats , 10 mg/kg; i.p. , CLP , , IL-6↓;HDL↑; survival rate↑ , [ ] .

Techniques: Phospho-proteomics