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Effect of the inhibition of HSP27 expression on ST61-treated MCF7 cell viability. MCF7 cells were transfected with 30 nM of either a predesigned scramble or <t>OGX-427.</t> Cells were further incubated for 72 h before ST61 addition at its 24 h IC 50 concentration (25 μΜ) for another 24 h, and their cell viability was assessed. Cell viability was expressed as the % ratio of cells treated with scramble in the absence of the compound. A representative experiment is depicted here ( n = 3). Asterisks denote statistically significant differences in comparison to the respective scramble (Student’s t -test, p < 0.05).
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Effect of the inhibition of HSP27 expression on ST61-treated MCF7 cell viability. MCF7 cells were transfected with 30 nM of either a predesigned scramble or <t>OGX-427.</t> Cells were further incubated for 72 h before ST61 addition at its 24 h IC 50 concentration (25 μΜ) for another 24 h, and their cell viability was assessed. Cell viability was expressed as the % ratio of cells treated with scramble in the absence of the compound. A representative experiment is depicted here ( n = 3). Asterisks denote statistically significant differences in comparison to the respective scramble (Student’s t -test, p < 0.05).
Antisense Oligonucleotide Based Inhibitor Targeting Prader Willi Angelman Region Rna 6 Pwar6, supplied by Angelman Syndrome Foundation, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Effect of the inhibition of HSP27 expression on ST61-treated MCF7 cell viability. MCF7 cells were transfected with 30 nM of either a predesigned scramble or <t>OGX-427.</t> Cells were further incubated for 72 h before ST61 addition at its 24 h IC 50 concentration (25 μΜ) for another 24 h, and their cell viability was assessed. Cell viability was expressed as the % ratio of cells treated with scramble in the absence of the compound. A representative experiment is depicted here ( n = 3). Asterisks denote statistically significant differences in comparison to the respective scramble (Student’s t -test, p < 0.05).
Antisense Oligonucleotide Drug Prax, supplied by Praxis Precision Medicines Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Effect of the inhibition of HSP27 expression on ST61-treated MCF7 cell viability. MCF7 cells were transfected with 30 nM of either a predesigned scramble or <t>OGX-427.</t> Cells were further incubated for 72 h before ST61 addition at its 24 h IC 50 concentration (25 μΜ) for another 24 h, and their cell viability was assessed. Cell viability was expressed as the % ratio of cells treated with scramble in the absence of the compound. A representative experiment is depicted here ( n = 3). Asterisks denote statistically significant differences in comparison to the respective scramble (Student’s t -test, p < 0.05).
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gampers antisense oligonucleotides 299 - by Bioz Stars, 2026-08
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antisense oligonucleotides  (Biogen Inc)
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Effect of the inhibition of HSP27 expression on ST61-treated MCF7 cell viability. MCF7 cells were transfected with 30 nM of either a predesigned scramble or <t>OGX-427.</t> Cells were further incubated for 72 h before ST61 addition at its 24 h IC 50 concentration (25 μΜ) for another 24 h, and their cell viability was assessed. Cell viability was expressed as the % ratio of cells treated with scramble in the absence of the compound. A representative experiment is depicted here ( n = 3). Asterisks denote statistically significant differences in comparison to the respective scramble (Student’s t -test, p < 0.05).
Antisense Oligonucleotides, supplied by Biogen Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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antisense oligonucleotides asos  (Innovative Therapies)
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Effect of the inhibition of HSP27 expression on ST61-treated MCF7 cell viability. MCF7 cells were transfected with 30 nM of either a predesigned scramble or <t>OGX-427.</t> Cells were further incubated for 72 h before ST61 addition at its 24 h IC 50 concentration (25 μΜ) for another 24 h, and their cell viability was assessed. Cell viability was expressed as the % ratio of cells treated with scramble in the absence of the compound. A representative experiment is depicted here ( n = 3). Asterisks denote statistically significant differences in comparison to the respective scramble (Student’s t -test, p < 0.05).
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Effect of the inhibition of HSP27 expression on ST61-treated MCF7 cell viability. MCF7 cells were transfected with 30 nM of either a predesigned scramble or <t>OGX-427.</t> Cells were further incubated for 72 h before ST61 addition at its 24 h IC 50 concentration (25 μΜ) for another 24 h, and their cell viability was assessed. Cell viability was expressed as the % ratio of cells treated with scramble in the absence of the compound. A representative experiment is depicted here ( n = 3). Asterisks denote statistically significant differences in comparison to the respective scramble (Student’s t -test, p < 0.05).
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Effect of the inhibition of HSP27 expression on ST61-treated MCF7 cell viability. MCF7 cells were transfected with 30 nM of either a predesigned scramble or <t>OGX-427.</t> Cells were further incubated for 72 h before ST61 addition at its 24 h IC 50 concentration (25 μΜ) for another 24 h, and their cell viability was assessed. Cell viability was expressed as the % ratio of cells treated with scramble in the absence of the compound. A representative experiment is depicted here ( n = 3). Asterisks denote statistically significant differences in comparison to the respective scramble (Student’s t -test, p < 0.05).
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Effect of the inhibition of HSP27 expression on ST61-treated MCF7 cell viability. MCF7 cells were transfected with 30 nM of either a predesigned scramble or <t>OGX-427.</t> Cells were further incubated for 72 h before ST61 addition at its 24 h IC 50 concentration (25 μΜ) for another 24 h, and their cell viability was assessed. Cell viability was expressed as the % ratio of cells treated with scramble in the absence of the compound. A representative experiment is depicted here ( n = 3). Asterisks denote statistically significant differences in comparison to the respective scramble (Student’s t -test, p < 0.05).
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antisense oligonucleotide targeting lipoprotein a - by Bioz Stars, 2026-08
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antisense oligonucleotides  (Innovative Therapies)
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Innovative Therapies antisense oligonucleotides
Effect of the inhibition of HSP27 expression on ST61-treated MCF7 cell viability. MCF7 cells were transfected with 30 nM of either a predesigned scramble or <t>OGX-427.</t> Cells were further incubated for 72 h before ST61 addition at its 24 h IC 50 concentration (25 μΜ) for another 24 h, and their cell viability was assessed. Cell viability was expressed as the % ratio of cells treated with scramble in the absence of the compound. A representative experiment is depicted here ( n = 3). Asterisks denote statistically significant differences in comparison to the respective scramble (Student’s t -test, p < 0.05).
Antisense Oligonucleotides, supplied by Innovative Therapies, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Effect of the inhibition of HSP27 expression on ST61-treated MCF7 cell viability. MCF7 cells were transfected with 30 nM of either a predesigned scramble or OGX-427. Cells were further incubated for 72 h before ST61 addition at its 24 h IC 50 concentration (25 μΜ) for another 24 h, and their cell viability was assessed. Cell viability was expressed as the % ratio of cells treated with scramble in the absence of the compound. A representative experiment is depicted here ( n = 3). Asterisks denote statistically significant differences in comparison to the respective scramble (Student’s t -test, p < 0.05).

Journal: Biomolecules

Article Title: Phenoxazine Derivative ST61 Displays an Oxidative-Stress-Mediated Cytotoxic Activity Against Human Cancer Cells

doi: 10.3390/biom16050689

Figure Lengend Snippet: Effect of the inhibition of HSP27 expression on ST61-treated MCF7 cell viability. MCF7 cells were transfected with 30 nM of either a predesigned scramble or OGX-427. Cells were further incubated for 72 h before ST61 addition at its 24 h IC 50 concentration (25 μΜ) for another 24 h, and their cell viability was assessed. Cell viability was expressed as the % ratio of cells treated with scramble in the absence of the compound. A representative experiment is depicted here ( n = 3). Asterisks denote statistically significant differences in comparison to the respective scramble (Student’s t -test, p < 0.05).

Article Snippet: Inhibition of HSP27 expression in MCF7 cells was performed by using the commercially available antisense oligonucleotide OGX-427 (MedChemExpress, South Brunswick Township, NJ, USA), designed to bind to HSP27 mRNA.

Techniques: Inhibition, Expressing, Transfection, Incubation, Concentration Assay, Comparison