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Clinical timeline, culture results, and <t>antimicrobial</t> therapy. Day of transplant is given as day zero. Antimicrobials are shaded by class/spectrum: blue, β-lactams and β-lactam/β-lactamase inhibitors; orange, tetracyclines; green, antibiotics with Gram-positive activity only; purple, antifungals. CR, carbapenem-resistant; ESBL, extended spectrum β-lactamse; ERCP, endoscopic retrograde cholangiopancreatography; IMP, active-on-imipenem; MDR, multidrug-resistant; NDM, New Delhi Metallo-β-lactamase; OXA, oxacillinase; PTC, percutaneous transhepatic cholangiography.
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Thermo Fisher antimicrobial panel
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Clinical timeline, culture results, and antimicrobial therapy. Day of transplant is given as day zero. Antimicrobials are shaded by class/spectrum: blue, β-lactams and β-lactam/β-lactamase inhibitors; orange, tetracyclines; green, antibiotics with Gram-positive activity only; purple, antifungals. CR, carbapenem-resistant; ESBL, extended spectrum β-lactamse; ERCP, endoscopic retrograde cholangiopancreatography; IMP, active-on-imipenem; MDR, multidrug-resistant; NDM, New Delhi Metallo-β-lactamase; OXA, oxacillinase; PTC, percutaneous transhepatic cholangiography.

Journal: JAC-Antimicrobial Resistance

Article Title: Cefepime-zidebactam therapy for extensively drug-resistant Pseudomonas aeruginosa and Klebsiella pneumoniae infection as a bridge to liver transplantation

doi: 10.1093/jacamr/dlaf129

Figure Lengend Snippet: Clinical timeline, culture results, and antimicrobial therapy. Day of transplant is given as day zero. Antimicrobials are shaded by class/spectrum: blue, β-lactams and β-lactam/β-lactamase inhibitors; orange, tetracyclines; green, antibiotics with Gram-positive activity only; purple, antifungals. CR, carbapenem-resistant; ESBL, extended spectrum β-lactamse; ERCP, endoscopic retrograde cholangiopancreatography; IMP, active-on-imipenem; MDR, multidrug-resistant; NDM, New Delhi Metallo-β-lactamase; OXA, oxacillinase; PTC, percutaneous transhepatic cholangiography.

Article Snippet: Antimicrobial susceptibility testing was performed in triplicate via broth microdilution at Johns Hopkins University School of Medicine using frozen antimicrobial panels in accordance with Clinical and Laboratory Standards Institute (CLSI) guidelines with interpretive criteria based on the M100 35th edition published in 2025.

Techniques: Activity Assay

Example picture of A. baumannii read by reference BMD and ComASP (red circle indicates MIC) (a) Reference BMD: Cefiderocol MIC = 64 µg/mL, (b) ComASP: Cefiderocol MIC = 128 µg/ml (MIC by CLSI read = 8 µg/mL).

Journal: Journal of Clinical Microbiology

Article Title: A multicenter performance evaluation of cefiderocol MIC results: ComASP in comparison to CLSI broth microdilution

doi: 10.1128/jcm.00926-24

Figure Lengend Snippet: Example picture of A. baumannii read by reference BMD and ComASP (red circle indicates MIC) (a) Reference BMD: Cefiderocol MIC = 64 µg/mL, (b) ComASP: Cefiderocol MIC = 128 µg/ml (MIC by CLSI read = 8 µg/mL).

Article Snippet: The performance of the Liofilchem Compact Antimicrobial Susceptibility Panel (ComASP) Cefiderocol was evaluated in a multicenter study.

Techniques:

Summary of  cefiderocol  ComASP reproducibility results by organism  (ComASP  reading method)

Journal: Journal of Clinical Microbiology

Article Title: A multicenter performance evaluation of cefiderocol MIC results: ComASP in comparison to CLSI broth microdilution

doi: 10.1128/jcm.00926-24

Figure Lengend Snippet: Summary of cefiderocol ComASP reproducibility results by organism (ComASP reading method)

Article Snippet: The performance of the Liofilchem Compact Antimicrobial Susceptibility Panel (ComASP) Cefiderocol was evaluated in a multicenter study.

Techniques:

Summary of  ComASP  using 2 different reading methods compared to CLSI BMD MIC by bacterial species for combined clinical and challenge organisms (category agreement and errors based on FDA breakpoints) <xref ref-type= a , b " width="100%" height="100%">

Journal: Journal of Clinical Microbiology

Article Title: A multicenter performance evaluation of cefiderocol MIC results: ComASP in comparison to CLSI broth microdilution

doi: 10.1128/jcm.00926-24

Figure Lengend Snippet: Summary of ComASP using 2 different reading methods compared to CLSI BMD MIC by bacterial species for combined clinical and challenge organisms (category agreement and errors based on FDA breakpoints) a , b

Article Snippet: The performance of the Liofilchem Compact Antimicrobial Susceptibility Panel (ComASP) Cefiderocol was evaluated in a multicenter study.

Techniques: Inhibition

Comparison of ComASP MIC distribution to BMD MIC distribution for 210 Enterobacterales* (combined clinical and challenge isolates; ComASP reading method; FDA/CLSI Breakpoints [indicated with red-dotted lines]).

Journal: Journal of Clinical Microbiology

Article Title: A multicenter performance evaluation of cefiderocol MIC results: ComASP in comparison to CLSI broth microdilution

doi: 10.1128/jcm.00926-24

Figure Lengend Snippet: Comparison of ComASP MIC distribution to BMD MIC distribution for 210 Enterobacterales* (combined clinical and challenge isolates; ComASP reading method; FDA/CLSI Breakpoints [indicated with red-dotted lines]).

Article Snippet: The performance of the Liofilchem Compact Antimicrobial Susceptibility Panel (ComASP) Cefiderocol was evaluated in a multicenter study.

Techniques: Comparison

Comparison of ComASP MIC distribution to BMD MIC distribution for 126 P . aeruginosa (combined clinical and challenge isolates; ComASP reading method) (a) FDA Breakpoints (indicated with red lines). (b) CLSI Breakpoints (indicated with red-dotted lines).

Journal: Journal of Clinical Microbiology

Article Title: A multicenter performance evaluation of cefiderocol MIC results: ComASP in comparison to CLSI broth microdilution

doi: 10.1128/jcm.00926-24

Figure Lengend Snippet: Comparison of ComASP MIC distribution to BMD MIC distribution for 126 P . aeruginosa (combined clinical and challenge isolates; ComASP reading method) (a) FDA Breakpoints (indicated with red lines). (b) CLSI Breakpoints (indicated with red-dotted lines).

Article Snippet: The performance of the Liofilchem Compact Antimicrobial Susceptibility Panel (ComASP) Cefiderocol was evaluated in a multicenter study.

Techniques: Comparison

Comparison of ComASP MIC distribution to BMD MIC distribution for 92 A . baumannii (combined clinical and challenge isolates; ComASP reading method) (a) FDA Breakpoints (indicated with red lines). (b) CLSI Breakpoints (indicated with red-dotted lines).

Journal: Journal of Clinical Microbiology

Article Title: A multicenter performance evaluation of cefiderocol MIC results: ComASP in comparison to CLSI broth microdilution

doi: 10.1128/jcm.00926-24

Figure Lengend Snippet: Comparison of ComASP MIC distribution to BMD MIC distribution for 92 A . baumannii (combined clinical and challenge isolates; ComASP reading method) (a) FDA Breakpoints (indicated with red lines). (b) CLSI Breakpoints (indicated with red-dotted lines).

Article Snippet: The performance of the Liofilchem Compact Antimicrobial Susceptibility Panel (ComASP) Cefiderocol was evaluated in a multicenter study.

Techniques: Comparison

Comparison of ComASP MIC distribution to BMD MIC distribution for 40 S . maltophilia (combined clinical and challenge isolates; ComASP reading method; CLSI breakpoint [indicated with red-dotted line]).

Journal: Journal of Clinical Microbiology

Article Title: A multicenter performance evaluation of cefiderocol MIC results: ComASP in comparison to CLSI broth microdilution

doi: 10.1128/jcm.00926-24

Figure Lengend Snippet: Comparison of ComASP MIC distribution to BMD MIC distribution for 40 S . maltophilia (combined clinical and challenge isolates; ComASP reading method; CLSI breakpoint [indicated with red-dotted line]).

Article Snippet: The performance of the Liofilchem Compact Antimicrobial Susceptibility Panel (ComASP) Cefiderocol was evaluated in a multicenter study.

Techniques: Comparison

Comparison of ComASP MIC distribution to BMD MIC distribution for Enterobacterales species that are not FDA clinically indicated (combined clinical and challenge isolates) (a) Consolidated Enterobacterales (non-clinically indicated species)*, CLSI Read, EA = 76.7% (b) Consolidated Enterobacterales (non-clinically indicated species)*, ComASP Read, EA = 95.3%.

Journal: Journal of Clinical Microbiology

Article Title: A multicenter performance evaluation of cefiderocol MIC results: ComASP in comparison to CLSI broth microdilution

doi: 10.1128/jcm.00926-24

Figure Lengend Snippet: Comparison of ComASP MIC distribution to BMD MIC distribution for Enterobacterales species that are not FDA clinically indicated (combined clinical and challenge isolates) (a) Consolidated Enterobacterales (non-clinically indicated species)*, CLSI Read, EA = 76.7% (b) Consolidated Enterobacterales (non-clinically indicated species)*, ComASP Read, EA = 95.3%.

Article Snippet: The performance of the Liofilchem Compact Antimicrobial Susceptibility Panel (ComASP) Cefiderocol was evaluated in a multicenter study.

Techniques: Comparison