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analog 22s  (Mimaki Engineering Co Ltd)
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Mimaki Engineering Co Ltd analog 22s
Analog 22s, supplied by Mimaki Engineering Co Ltd, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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fluorescein isothiocyanate fitc analog  (Thermo Fisher)
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Thermo Fisher fluorescein isothiocyanate fitc analog
A) Schematic representation of competition assays between [ 68 Ga]AJ647 and EV for binding to Nectin-4. On the left, the schematic illustrates the impact of varying EV concentrations on Nectin-4 levels, with accessible Nectin-4 quantified using [ 68 Ga]AJ647. On the right, the schematic depicts how varying concentrations of AJ647 affect Nectin-4 levels, with accessible Nectin-4 determined by <t>EV-FITC</t> binding. B) In vitro binding of [ 68 Ga]AJ647 to HT1376 cells with varying concentrations of EV. The data show concentration-dependent inhibition of [ 68 Ga]AJ647 binding, with an IC 50 of 2.7 nM, indicating the competitive nature of EV in blocking [ 68 Ga]AJ647 binding to Nectin-4. C) In vitro binding of EV-FITC to HT1376 cells, assessed by flow cytometry, with varying concentrations of AJ647. The results demonstrate concentration-dependent inhibition of EV-FITC binding, with an IC 50 of 35 nM, highlighting that AJ647 competes with EV-FITC for Nectin-4 binding. data represented as mean±SD (n=3–4). D) In vitro binding of [ 68 Ga]AJ647 to HT1376, SCaBER and T24 cells with and without 60 nM EV. E) In vivo PET-CT imaging in mice harboring SCaBER (left) and HT1376 (right) tumors pre- and post- 20 mpk EV treatment (n=2). PET-CT was acquired 60-minutes after 7.4 MBq (~200 μCi) [ 68 Ga]AJ647 injection. E) In vivo PET-CT imaging in mice harboring SCaBER (left) and HT1376 (right) tumors at saturating dose of 20 mpk or saline (n=2). PET-CT was acquired at 60-minutes after 7.4 MBq (~200 μCi) [ 68 Ga]AJ647 injection. F) Ex vivo biodistribution in mice harboring SCaBER (left) and HT1376 (right) tumors treated with 20 mpk or saline control (n=5). Mice were sacrificed at 60-minutes after 1.85 MBq (~50 μCi) [ 68 Ga]AJ647 injection.
Fluorescein Isothiocyanate Fitc Analog, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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analog 22 against s aureus atcc 25923  (ATCC)
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ATCC analog 22 against s aureus atcc 25923
A) Schematic representation of competition assays between [ 68 Ga]AJ647 and EV for binding to Nectin-4. On the left, the schematic illustrates the impact of varying EV concentrations on Nectin-4 levels, with accessible Nectin-4 quantified using [ 68 Ga]AJ647. On the right, the schematic depicts how varying concentrations of AJ647 affect Nectin-4 levels, with accessible Nectin-4 determined by <t>EV-FITC</t> binding. B) In vitro binding of [ 68 Ga]AJ647 to HT1376 cells with varying concentrations of EV. The data show concentration-dependent inhibition of [ 68 Ga]AJ647 binding, with an IC 50 of 2.7 nM, indicating the competitive nature of EV in blocking [ 68 Ga]AJ647 binding to Nectin-4. C) In vitro binding of EV-FITC to HT1376 cells, assessed by flow cytometry, with varying concentrations of AJ647. The results demonstrate concentration-dependent inhibition of EV-FITC binding, with an IC 50 of 35 nM, highlighting that AJ647 competes with EV-FITC for Nectin-4 binding. data represented as mean±SD (n=3–4). D) In vitro binding of [ 68 Ga]AJ647 to HT1376, SCaBER and T24 cells with and without 60 nM EV. E) In vivo PET-CT imaging in mice harboring SCaBER (left) and HT1376 (right) tumors pre- and post- 20 mpk EV treatment (n=2). PET-CT was acquired 60-minutes after 7.4 MBq (~200 μCi) [ 68 Ga]AJ647 injection. E) In vivo PET-CT imaging in mice harboring SCaBER (left) and HT1376 (right) tumors at saturating dose of 20 mpk or saline (n=2). PET-CT was acquired at 60-minutes after 7.4 MBq (~200 μCi) [ 68 Ga]AJ647 injection. F) Ex vivo biodistribution in mice harboring SCaBER (left) and HT1376 (right) tumors treated with 20 mpk or saline control (n=5). Mice were sacrificed at 60-minutes after 1.85 MBq (~50 μCi) [ 68 Ga]AJ647 injection.
Analog 22 Against S Aureus Atcc 25923, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/analog+22s/Staphylococcus+aureus+subsp%2E+aureus+Rosenbach/pm38537511-310-16-21
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analog 22 against p aeruginosa atcc 27853  (ATCC)
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ATCC analog 22 against p aeruginosa atcc 27853
A) Schematic representation of competition assays between [ 68 Ga]AJ647 and EV for binding to Nectin-4. On the left, the schematic illustrates the impact of varying EV concentrations on Nectin-4 levels, with accessible Nectin-4 quantified using [ 68 Ga]AJ647. On the right, the schematic depicts how varying concentrations of AJ647 affect Nectin-4 levels, with accessible Nectin-4 determined by <t>EV-FITC</t> binding. B) In vitro binding of [ 68 Ga]AJ647 to HT1376 cells with varying concentrations of EV. The data show concentration-dependent inhibition of [ 68 Ga]AJ647 binding, with an IC 50 of 2.7 nM, indicating the competitive nature of EV in blocking [ 68 Ga]AJ647 binding to Nectin-4. C) In vitro binding of EV-FITC to HT1376 cells, assessed by flow cytometry, with varying concentrations of AJ647. The results demonstrate concentration-dependent inhibition of EV-FITC binding, with an IC 50 of 35 nM, highlighting that AJ647 competes with EV-FITC for Nectin-4 binding. data represented as mean±SD (n=3–4). D) In vitro binding of [ 68 Ga]AJ647 to HT1376, SCaBER and T24 cells with and without 60 nM EV. E) In vivo PET-CT imaging in mice harboring SCaBER (left) and HT1376 (right) tumors pre- and post- 20 mpk EV treatment (n=2). PET-CT was acquired 60-minutes after 7.4 MBq (~200 μCi) [ 68 Ga]AJ647 injection. E) In vivo PET-CT imaging in mice harboring SCaBER (left) and HT1376 (right) tumors at saturating dose of 20 mpk or saline (n=2). PET-CT was acquired at 60-minutes after 7.4 MBq (~200 μCi) [ 68 Ga]AJ647 injection. F) Ex vivo biodistribution in mice harboring SCaBER (left) and HT1376 (right) tumors treated with 20 mpk or saline control (n=5). Mice were sacrificed at 60-minutes after 1.85 MBq (~50 μCi) [ 68 Ga]AJ647 injection.
Analog 22 Against P Aeruginosa Atcc 27853, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/analog+22s/Pseudomonas+aeruginosa+(Schroeter)+Migula/pm38537511-355-40-45
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led and analog driver lcs-0470-03-22, sla-1000-2  (Mightex Systems)
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Mightex Systems led and analog driver lcs-0470-03-22, sla-1000-2
A) Schematic representation of competition assays between [ 68 Ga]AJ647 and EV for binding to Nectin-4. On the left, the schematic illustrates the impact of varying EV concentrations on Nectin-4 levels, with accessible Nectin-4 quantified using [ 68 Ga]AJ647. On the right, the schematic depicts how varying concentrations of AJ647 affect Nectin-4 levels, with accessible Nectin-4 determined by <t>EV-FITC</t> binding. B) In vitro binding of [ 68 Ga]AJ647 to HT1376 cells with varying concentrations of EV. The data show concentration-dependent inhibition of [ 68 Ga]AJ647 binding, with an IC 50 of 2.7 nM, indicating the competitive nature of EV in blocking [ 68 Ga]AJ647 binding to Nectin-4. C) In vitro binding of EV-FITC to HT1376 cells, assessed by flow cytometry, with varying concentrations of AJ647. The results demonstrate concentration-dependent inhibition of EV-FITC binding, with an IC 50 of 35 nM, highlighting that AJ647 competes with EV-FITC for Nectin-4 binding. data represented as mean±SD (n=3–4). D) In vitro binding of [ 68 Ga]AJ647 to HT1376, SCaBER and T24 cells with and without 60 nM EV. E) In vivo PET-CT imaging in mice harboring SCaBER (left) and HT1376 (right) tumors pre- and post- 20 mpk EV treatment (n=2). PET-CT was acquired 60-minutes after 7.4 MBq (~200 μCi) [ 68 Ga]AJ647 injection. E) In vivo PET-CT imaging in mice harboring SCaBER (left) and HT1376 (right) tumors at saturating dose of 20 mpk or saline (n=2). PET-CT was acquired at 60-minutes after 7.4 MBq (~200 μCi) [ 68 Ga]AJ647 injection. F) Ex vivo biodistribution in mice harboring SCaBER (left) and HT1376 (right) tumors treated with 20 mpk or saline control (n=5). Mice were sacrificed at 60-minutes after 1.85 MBq (~50 μCi) [ 68 Ga]AJ647 injection.
Led And Analog Driver Lcs 0470 03 22, Sla 1000 2, supplied by Mightex Systems, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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led and analog driver lcs-0470-03-22, sla-1000-2 - by Bioz Stars, 2026-10
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cdi analogs 22–33  (Chemdiv Inc)
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Chemdiv Inc cdi analogs 22–33
A) Schematic representation of competition assays between [ 68 Ga]AJ647 and EV for binding to Nectin-4. On the left, the schematic illustrates the impact of varying EV concentrations on Nectin-4 levels, with accessible Nectin-4 quantified using [ 68 Ga]AJ647. On the right, the schematic depicts how varying concentrations of AJ647 affect Nectin-4 levels, with accessible Nectin-4 determined by <t>EV-FITC</t> binding. B) In vitro binding of [ 68 Ga]AJ647 to HT1376 cells with varying concentrations of EV. The data show concentration-dependent inhibition of [ 68 Ga]AJ647 binding, with an IC 50 of 2.7 nM, indicating the competitive nature of EV in blocking [ 68 Ga]AJ647 binding to Nectin-4. C) In vitro binding of EV-FITC to HT1376 cells, assessed by flow cytometry, with varying concentrations of AJ647. The results demonstrate concentration-dependent inhibition of EV-FITC binding, with an IC 50 of 35 nM, highlighting that AJ647 competes with EV-FITC for Nectin-4 binding. data represented as mean±SD (n=3–4). D) In vitro binding of [ 68 Ga]AJ647 to HT1376, SCaBER and T24 cells with and without 60 nM EV. E) In vivo PET-CT imaging in mice harboring SCaBER (left) and HT1376 (right) tumors pre- and post- 20 mpk EV treatment (n=2). PET-CT was acquired 60-minutes after 7.4 MBq (~200 μCi) [ 68 Ga]AJ647 injection. E) In vivo PET-CT imaging in mice harboring SCaBER (left) and HT1376 (right) tumors at saturating dose of 20 mpk or saline (n=2). PET-CT was acquired at 60-minutes after 7.4 MBq (~200 μCi) [ 68 Ga]AJ647 injection. F) Ex vivo biodistribution in mice harboring SCaBER (left) and HT1376 (right) tumors treated with 20 mpk or saline control (n=5). Mice were sacrificed at 60-minutes after 1.85 MBq (~50 μCi) [ 68 Ga]AJ647 injection.
Cdi Analogs 22–33, supplied by Chemdiv Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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cdi analogs 22–33 - by Bioz Stars, 2026-10
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non hepatotoxic analog  (Thermo Fisher)
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Thermo Fisher non hepatotoxic analog
A) Schematic representation of competition assays between [ 68 Ga]AJ647 and EV for binding to Nectin-4. On the left, the schematic illustrates the impact of varying EV concentrations on Nectin-4 levels, with accessible Nectin-4 quantified using [ 68 Ga]AJ647. On the right, the schematic depicts how varying concentrations of AJ647 affect Nectin-4 levels, with accessible Nectin-4 determined by <t>EV-FITC</t> binding. B) In vitro binding of [ 68 Ga]AJ647 to HT1376 cells with varying concentrations of EV. The data show concentration-dependent inhibition of [ 68 Ga]AJ647 binding, with an IC 50 of 2.7 nM, indicating the competitive nature of EV in blocking [ 68 Ga]AJ647 binding to Nectin-4. C) In vitro binding of EV-FITC to HT1376 cells, assessed by flow cytometry, with varying concentrations of AJ647. The results demonstrate concentration-dependent inhibition of EV-FITC binding, with an IC 50 of 35 nM, highlighting that AJ647 competes with EV-FITC for Nectin-4 binding. data represented as mean±SD (n=3–4). D) In vitro binding of [ 68 Ga]AJ647 to HT1376, SCaBER and T24 cells with and without 60 nM EV. E) In vivo PET-CT imaging in mice harboring SCaBER (left) and HT1376 (right) tumors pre- and post- 20 mpk EV treatment (n=2). PET-CT was acquired 60-minutes after 7.4 MBq (~200 μCi) [ 68 Ga]AJ647 injection. E) In vivo PET-CT imaging in mice harboring SCaBER (left) and HT1376 (right) tumors at saturating dose of 20 mpk or saline (n=2). PET-CT was acquired at 60-minutes after 7.4 MBq (~200 μCi) [ 68 Ga]AJ647 injection. F) Ex vivo biodistribution in mice harboring SCaBER (left) and HT1376 (right) tumors treated with 20 mpk or saline control (n=5). Mice were sacrificed at 60-minutes after 1.85 MBq (~50 μCi) [ 68 Ga]AJ647 injection.
Non Hepatotoxic Analog, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/analog+22s/3-Acetamidophenol%2C+98%25/pmc09326545-38-17-20
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non hepatotoxic analog - by Bioz Stars, 2026-10
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analog 22  (Kamei Co Ltd)
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Kamei Co Ltd analog 22
A) Schematic representation of competition assays between [ 68 Ga]AJ647 and EV for binding to Nectin-4. On the left, the schematic illustrates the impact of varying EV concentrations on Nectin-4 levels, with accessible Nectin-4 quantified using [ 68 Ga]AJ647. On the right, the schematic depicts how varying concentrations of AJ647 affect Nectin-4 levels, with accessible Nectin-4 determined by <t>EV-FITC</t> binding. B) In vitro binding of [ 68 Ga]AJ647 to HT1376 cells with varying concentrations of EV. The data show concentration-dependent inhibition of [ 68 Ga]AJ647 binding, with an IC 50 of 2.7 nM, indicating the competitive nature of EV in blocking [ 68 Ga]AJ647 binding to Nectin-4. C) In vitro binding of EV-FITC to HT1376 cells, assessed by flow cytometry, with varying concentrations of AJ647. The results demonstrate concentration-dependent inhibition of EV-FITC binding, with an IC 50 of 35 nM, highlighting that AJ647 competes with EV-FITC for Nectin-4 binding. data represented as mean±SD (n=3–4). D) In vitro binding of [ 68 Ga]AJ647 to HT1376, SCaBER and T24 cells with and without 60 nM EV. E) In vivo PET-CT imaging in mice harboring SCaBER (left) and HT1376 (right) tumors pre- and post- 20 mpk EV treatment (n=2). PET-CT was acquired 60-minutes after 7.4 MBq (~200 μCi) [ 68 Ga]AJ647 injection. E) In vivo PET-CT imaging in mice harboring SCaBER (left) and HT1376 (right) tumors at saturating dose of 20 mpk or saline (n=2). PET-CT was acquired at 60-minutes after 7.4 MBq (~200 μCi) [ 68 Ga]AJ647 injection. F) Ex vivo biodistribution in mice harboring SCaBER (left) and HT1376 (right) tumors treated with 20 mpk or saline control (n=5). Mice were sacrificed at 60-minutes after 1.85 MBq (~50 μCi) [ 68 Ga]AJ647 injection.
Analog 22, supplied by Kamei Co Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


A) Schematic representation of competition assays between [ 68 Ga]AJ647 and EV for binding to Nectin-4. On the left, the schematic illustrates the impact of varying EV concentrations on Nectin-4 levels, with accessible Nectin-4 quantified using [ 68 Ga]AJ647. On the right, the schematic depicts how varying concentrations of AJ647 affect Nectin-4 levels, with accessible Nectin-4 determined by EV-FITC binding. B) In vitro binding of [ 68 Ga]AJ647 to HT1376 cells with varying concentrations of EV. The data show concentration-dependent inhibition of [ 68 Ga]AJ647 binding, with an IC 50 of 2.7 nM, indicating the competitive nature of EV in blocking [ 68 Ga]AJ647 binding to Nectin-4. C) In vitro binding of EV-FITC to HT1376 cells, assessed by flow cytometry, with varying concentrations of AJ647. The results demonstrate concentration-dependent inhibition of EV-FITC binding, with an IC 50 of 35 nM, highlighting that AJ647 competes with EV-FITC for Nectin-4 binding. data represented as mean±SD (n=3–4). D) In vitro binding of [ 68 Ga]AJ647 to HT1376, SCaBER and T24 cells with and without 60 nM EV. E) In vivo PET-CT imaging in mice harboring SCaBER (left) and HT1376 (right) tumors pre- and post- 20 mpk EV treatment (n=2). PET-CT was acquired 60-minutes after 7.4 MBq (~200 μCi) [ 68 Ga]AJ647 injection. E) In vivo PET-CT imaging in mice harboring SCaBER (left) and HT1376 (right) tumors at saturating dose of 20 mpk or saline (n=2). PET-CT was acquired at 60-minutes after 7.4 MBq (~200 μCi) [ 68 Ga]AJ647 injection. F) Ex vivo biodistribution in mice harboring SCaBER (left) and HT1376 (right) tumors treated with 20 mpk or saline control (n=5). Mice were sacrificed at 60-minutes after 1.85 MBq (~50 μCi) [ 68 Ga]AJ647 injection.

Journal: bioRxiv

Article Title: NECTIN-4 PET FOR OPTIMIZING ENFORTUMAB VEDOTIN DOSE-RESPONSE IN UROTHELIAL CARCINOMA

doi: 10.1101/2024.12.25.630315

Figure Lengend Snippet: A) Schematic representation of competition assays between [ 68 Ga]AJ647 and EV for binding to Nectin-4. On the left, the schematic illustrates the impact of varying EV concentrations on Nectin-4 levels, with accessible Nectin-4 quantified using [ 68 Ga]AJ647. On the right, the schematic depicts how varying concentrations of AJ647 affect Nectin-4 levels, with accessible Nectin-4 determined by EV-FITC binding. B) In vitro binding of [ 68 Ga]AJ647 to HT1376 cells with varying concentrations of EV. The data show concentration-dependent inhibition of [ 68 Ga]AJ647 binding, with an IC 50 of 2.7 nM, indicating the competitive nature of EV in blocking [ 68 Ga]AJ647 binding to Nectin-4. C) In vitro binding of EV-FITC to HT1376 cells, assessed by flow cytometry, with varying concentrations of AJ647. The results demonstrate concentration-dependent inhibition of EV-FITC binding, with an IC 50 of 35 nM, highlighting that AJ647 competes with EV-FITC for Nectin-4 binding. data represented as mean±SD (n=3–4). D) In vitro binding of [ 68 Ga]AJ647 to HT1376, SCaBER and T24 cells with and without 60 nM EV. E) In vivo PET-CT imaging in mice harboring SCaBER (left) and HT1376 (right) tumors pre- and post- 20 mpk EV treatment (n=2). PET-CT was acquired 60-minutes after 7.4 MBq (~200 μCi) [ 68 Ga]AJ647 injection. E) In vivo PET-CT imaging in mice harboring SCaBER (left) and HT1376 (right) tumors at saturating dose of 20 mpk or saline (n=2). PET-CT was acquired at 60-minutes after 7.4 MBq (~200 μCi) [ 68 Ga]AJ647 injection. F) Ex vivo biodistribution in mice harboring SCaBER (left) and HT1376 (right) tumors treated with 20 mpk or saline control (n=5). Mice were sacrificed at 60-minutes after 1.85 MBq (~50 μCi) [ 68 Ga]AJ647 injection.

Article Snippet: Fluorescein isothiocyanate (FITC) analog of EV was made using manufacturer recommended protocol (Thermo #46409).

Techniques: Binding Assay, In Vitro, Concentration Assay, Inhibition, Blocking Assay, Flow Cytometry, In Vivo, Positron Emission Tomography-Computed Tomography, Imaging, Injection, Saline, Ex Vivo, Control