Journal: Pharmaceutics

Article Title: Alectinib-Loaded Chitosan–Alginate Nanoparticles: A Novel Synthesis Method with In Vitro and In Vivo Evaluations

doi: 10.3390/pharmaceutics17040492

Figure Lengend Snippet: The inhibitory role of Alectinib on EML4-ALK-positive NSCLC.

Article Snippet: Alectinib hydrochloride was obtained from (Biosynth Zurich, Switzerland, distributed by Cymit Química S.L., Barcelona, Spain) while dimethyl sulfoxide (DMSO) was sourced from EMSURE ® in Grove Village, IL, USA.

Techniques:

Journal: Pharmaceutics

Article Title: Alectinib-Loaded Chitosan–Alginate Nanoparticles: A Novel Synthesis Method with In Vitro and In Vivo Evaluations

doi: 10.3390/pharmaceutics17040492

Figure Lengend Snippet: The synthesis process of Alectinib-loaded chitosan–alginate nanoparticles.

Article Snippet: Alectinib hydrochloride was obtained from (Biosynth Zurich, Switzerland, distributed by Cymit Química S.L., Barcelona, Spain) while dimethyl sulfoxide (DMSO) was sourced from EMSURE ® in Grove Village, IL, USA.

Techniques:

Journal: Pharmaceutics

Article Title: Alectinib-Loaded Chitosan–Alginate Nanoparticles: A Novel Synthesis Method with In Vitro and In Vivo Evaluations

doi: 10.3390/pharmaceutics17040492

Figure Lengend Snippet: The chromatogram of Alectinib 12.5 µg/mL solution in methanol and the chromatogram of the mobile phase.

Article Snippet: Alectinib hydrochloride was obtained from (Biosynth Zurich, Switzerland, distributed by Cymit Química S.L., Barcelona, Spain) while dimethyl sulfoxide (DMSO) was sourced from EMSURE ® in Grove Village, IL, USA.

Techniques:

Journal: Pharmaceutics

Article Title: Alectinib-Loaded Chitosan–Alginate Nanoparticles: A Novel Synthesis Method with In Vitro and In Vivo Evaluations

doi: 10.3390/pharmaceutics17040492

Figure Lengend Snippet: The encapsulation efficiency (EE %), ratios, solubilizing agents, and the method used of NP optimization.

Article Snippet: Alectinib hydrochloride was obtained from (Biosynth Zurich, Switzerland, distributed by Cymit Química S.L., Barcelona, Spain) while dimethyl sulfoxide (DMSO) was sourced from EMSURE ® in Grove Village, IL, USA.

Techniques: Encapsulation, Emulsification

Journal: Pharmaceutics

Article Title: Alectinib-Loaded Chitosan–Alginate Nanoparticles: A Novel Synthesis Method with In Vitro and In Vivo Evaluations

doi: 10.3390/pharmaceutics17040492

Figure Lengend Snippet: The FTIR spectra of Alectinib, chitosan, alginate, and their mixture.

Article Snippet: Alectinib hydrochloride was obtained from (Biosynth Zurich, Switzerland, distributed by Cymit Química S.L., Barcelona, Spain) while dimethyl sulfoxide (DMSO) was sourced from EMSURE ® in Grove Village, IL, USA.

Techniques:

Journal: Pharmaceutics

Article Title: Alectinib-Loaded Chitosan–Alginate Nanoparticles: A Novel Synthesis Method with In Vitro and In Vivo Evaluations

doi: 10.3390/pharmaceutics17040492

Figure Lengend Snippet: Comparison of characteristic FTIR absorption bands of Alectinib, chitosan, alginate, and their physical mixture.

Article Snippet: Alectinib hydrochloride was obtained from (Biosynth Zurich, Switzerland, distributed by Cymit Química S.L., Barcelona, Spain) while dimethyl sulfoxide (DMSO) was sourced from EMSURE ® in Grove Village, IL, USA.

Techniques: Comparison

Journal: Pharmaceutics

Article Title: Alectinib-Loaded Chitosan–Alginate Nanoparticles: A Novel Synthesis Method with In Vitro and In Vivo Evaluations

doi: 10.3390/pharmaceutics17040492

Figure Lengend Snippet: DSC thermograms of pure Alectinib, chitosan, alginate, and ACANPs showing changes in thermal behavior, indicating drug encapsulation and transformation into the amorphous state.

Article Snippet: Alectinib hydrochloride was obtained from (Biosynth Zurich, Switzerland, distributed by Cymit Química S.L., Barcelona, Spain) while dimethyl sulfoxide (DMSO) was sourced from EMSURE ® in Grove Village, IL, USA.

Techniques: Encapsulation, Transformation Assay

Journal: Pharmaceutics

Article Title: Alectinib-Loaded Chitosan–Alginate Nanoparticles: A Novel Synthesis Method with In Vitro and In Vivo Evaluations

doi: 10.3390/pharmaceutics17040492

Figure Lengend Snippet: An in vitro release plot of Alectinib at 6.8 pH from the ACANPs and the free drug.

Article Snippet: Alectinib hydrochloride was obtained from (Biosynth Zurich, Switzerland, distributed by Cymit Química S.L., Barcelona, Spain) while dimethyl sulfoxide (DMSO) was sourced from EMSURE ® in Grove Village, IL, USA.

Techniques: In Vitro

Journal: Pharmaceutics

Article Title: Alectinib-Loaded Chitosan–Alginate Nanoparticles: A Novel Synthesis Method with In Vitro and In Vivo Evaluations

doi: 10.3390/pharmaceutics17040492

Figure Lengend Snippet: ( A ) LC-MS/MS chromatogram for the blank sample with no peak of Alectinib. ( B ) Alectinib at 483,300 Da, height: 2.48 × 10 3 cps, RT: 0.504 min. ( C ) Rosuvastatin (internal standard) at 482,200 Da, height: 1.64 × 10 5 cps, RT: 0.750 min.

Article Snippet: Alectinib hydrochloride was obtained from (Biosynth Zurich, Switzerland, distributed by Cymit Química S.L., Barcelona, Spain) while dimethyl sulfoxide (DMSO) was sourced from EMSURE ® in Grove Village, IL, USA.

Techniques: Liquid Chromatography with Mass Spectroscopy

Journal: Pharmaceutics

Article Title: Alectinib-Loaded Chitosan–Alginate Nanoparticles: A Novel Synthesis Method with In Vitro and In Vivo Evaluations

doi: 10.3390/pharmaceutics17040492

Figure Lengend Snippet: The plasma concentration–time profiles of Alectinib in the ACANP formulation and the free drug.

Article Snippet: Alectinib hydrochloride was obtained from (Biosynth Zurich, Switzerland, distributed by Cymit Química S.L., Barcelona, Spain) while dimethyl sulfoxide (DMSO) was sourced from EMSURE ® in Grove Village, IL, USA.

Techniques: Clinical Proteomics, Concentration Assay, Formulation

Journal: Pharmaceutics

Article Title: Alectinib-Loaded Chitosan–Alginate Nanoparticles: A Novel Synthesis Method with In Vitro and In Vivo Evaluations

doi: 10.3390/pharmaceutics17040492

Figure Lengend Snippet: Pharmacokinetic parameters of free Alectinib and ACANP formulation.

Article Snippet: Alectinib hydrochloride was obtained from (Biosynth Zurich, Switzerland, distributed by Cymit Química S.L., Barcelona, Spain) while dimethyl sulfoxide (DMSO) was sourced from EMSURE ® in Grove Village, IL, USA.

Techniques: Formulation

Journal: iScience

Article Title: AXL and SHC1 confer crizotinib resistance in patient-derived xenograft model of ALK-driven lung cancer

doi: 10.1016/j.isci.2024.110846

Figure Lengend Snippet:

Article Snippet: Alectinb , Selleck Chemicals , Cat#S5232.

Techniques: Recombinant, Proliferation Assay, cDNA Synthesis, Multiplex Assay, Sequencing, Mass Spectrometry, DNA Sequencing