Journal: Journal of Agricultural and Food Chemistry

Article Title: Pesticide, Veterinary Medicines, and Microplastics: Bipartite and Tripartite Interactions Drive the Transformation of Albendazole and Pyraclostrobin in Agricultural Soils

doi: 10.1021/acs.jafc.5c09441

Figure Lengend Snippet: Effects of different types of microplastics (MPs) and their mixture, applied at two different concentrations (0.01 and 0.1%), on the dissipation of Albendazole (ABZ) and its transformation products albendazole sulfoxide (ABZSO) and albendazole sulfone (ABZSO2) in Greek soil: (a) No MPs, (b) LDPE-based 0.01%, (c) LDPE-based 0.1%, (d) PBAT-based 0.01%, (e) PBAT-based 0.1%, (f) Starch-based 0.01%, (g) Starch-based 0.1%, (h) MPs mixture 0.01%, and (i) MPs mixture 0.1%.

Article Snippet: Albendazole sulfone (ABZSO 2 97% purity) was purchased from Santa Cruz Biotech (Heidelberg, Germany).

Techniques: Transformation Assay, Starch

Journal: Journal of Agricultural and Food Chemistry

Article Title: Pesticide, Veterinary Medicines, and Microplastics: Bipartite and Tripartite Interactions Drive the Transformation of Albendazole and Pyraclostrobin in Agricultural Soils

doi: 10.1021/acs.jafc.5c09441

Figure Lengend Snippet: Combined effects of different microplastics (MPs), applied at two concentrations (0.01% and 0.1%), and pyraclostrobin (PYR) on the dissipation of Albendazole (ABZ) and its transformation products albendazole sulfoxide (ABZSO) and albendazole sulfone (ABZSO2) in Greek soil: (a) No MPs, (b) LDPE-based 0.01%, (c) LDPE-based 0.1%, (d) PBAT-based 0.01%, (e) PBAT-based 0.1%, (f) Starch-based 0.01%, (g) Starch-based 0.1%, (h) MPs mixture 0.01%, and (i) MPs mixture 0.1%.

Article Snippet: Albendazole sulfone (ABZSO 2 97% purity) was purchased from Santa Cruz Biotech (Heidelberg, Germany).

Techniques: Transformation Assay, Starch

Journal: Journal of Agricultural and Food Chemistry

Article Title: Pesticide, Veterinary Medicines, and Microplastics: Bipartite and Tripartite Interactions Drive the Transformation of Albendazole and Pyraclostrobin in Agricultural Soils

doi: 10.1021/acs.jafc.5c09441

Figure Lengend Snippet: Concentrations of albendazole (ABZ) measured at 30 and 90 days postapplication in the absence (A, C) and presence of pyraclostrobin (PYR) (B, D) in samples from Dutch and French soil that had been treated as follows: (a) No MPs, (b) LDPE-based 0.01%, (c) LDPE-based 0.1%, (d) PBAT-based 0.01%, (e) PBAT-based 0.1%, (f) Starch-based 0.01%, (g) Starch-based 0.1%, (h) MPs mixture 0.01%, and (i) MPs mixture 0.1%. In the boxplot graph, bars designated by the same letters are not significantly different at the 5% level.

Article Snippet: Albendazole sulfone (ABZSO 2 97% purity) was purchased from Santa Cruz Biotech (Heidelberg, Germany).

Techniques: Starch

Journal: Journal of Agricultural and Food Chemistry

Article Title: Pesticide, Veterinary Medicines, and Microplastics: Bipartite and Tripartite Interactions Drive the Transformation of Albendazole and Pyraclostrobin in Agricultural Soils

doi: 10.1021/acs.jafc.5c09441

Figure Lengend Snippet: Effects of different types of microplastics (MPs) and their mixture, applied at two different concentrations (0.01% and 0.1%), on the dissipation of pyraclostrobin (PYR), applied either alone or with albendazole (ABZ) in Greek soil: (a) No MPs, (b) LDPE-based 0.01%, (c) LDPE-based 0.1%, (d) PBAT-based 0.01%, (e) PBAT-based 0.1%, (f) Starch-based 0.01%, (g) Starch-based 0.1%, (h) MPs mixture 0.01%, and (i) MPs mixture 0.1%.

Article Snippet: Albendazole sulfone (ABZSO 2 97% purity) was purchased from Santa Cruz Biotech (Heidelberg, Germany).

Techniques: Starch

Journal: Journal of Agricultural and Food Chemistry

Article Title: Pesticide, Veterinary Medicines, and Microplastics: Bipartite and Tripartite Interactions Drive the Transformation of Albendazole and Pyraclostrobin in Agricultural Soils

doi: 10.1021/acs.jafc.5c09441

Figure Lengend Snippet: Concentrations of pyraclostrobin (PYR) measured at 30 and 90 days post application in the absence (A, C) and presence of albendazole (ABZ) (B, D) in samples from Dutch and French soil that had been as follows: (a) No MPs, (b) LDPE-based 0.01%, (c) LDPE-based 0.1%, (d) PBAT-based 0.01%, (e) PBAT-based 0.1%, (f) Starch-based 0.01%, (g) Starch-based 0.1%, (h) MPs Mixture 0.01%, (i) MPs mixture 0.1%. In the boxplot graph, bars designated by the same letters are not significantly different at the 5% level.

Article Snippet: Albendazole sulfone (ABZSO 2 97% purity) was purchased from Santa Cruz Biotech (Heidelberg, Germany).

Techniques: Starch

Journal: ACS Omega

Article Title: An Integrated Approach of Proteomic, Cheminformatic, and In Vitro Drug Screening to Identify Potential Therapeutic Targets of Taenia solium Cysticerci Proteases

doi: 10.1021/acsomega.4c07758

Figure Lengend Snippet: Cytotoxic effect of phenyl vinyl sulfone (PVS) and 1,10-phenanthroline on HEK293T (A, C) and HepG2 (B, D) cell lines compared with anthelminthic drugs (albendazole sulfoxide and praziquantel) at various concentrations (A, B) and dilutions of IC50 values (C, D). 1,10-Phenanthroline showed least cytotoxicity in every condition. Dose-dependent study of 1,10-phenanthroline to identify the minimum inhibitory concentration of protease inhibitor (E). Images are representative for three independent biological experiments.

Article Snippet: The cysticerci were treated with the following protease inhibitors: metalloprotease inhibitor (1,10-phenanthroline), cysteine protease inhibitor [phenyl vinyl sulfone (PVS)], and serine protease inhibitor (aprotinin and 2-pyrimidine carbonitrile) and IC50 values of drugs (belinostat and irinotecan hydrochloride)., Along with this, the viable cysts were treated with albendazole sulfoxide (ABZ) (Merck, A35395) and praziquantel (PZQ) (Merck, P4668), which are drugs of choice as anthelminthic and served as a positive control.

Techniques: Concentration Assay, Protease Inhibitor

Journal: ACS Omega

Article Title: An Integrated Approach of Proteomic, Cheminformatic, and In Vitro Drug Screening to Identify Potential Therapeutic Targets of Taenia solium Cysticerci Proteases

doi: 10.1021/acsomega.4c07758

Figure Lengend Snippet: Relative gene expression analysis of pro- and anti-inflammatory cytokines in three different cell lines of 1,10-phenanthroline (25 μg/mL) by QPCR. (A) dTHP-1 cells, (B) HepG2 cells, and (C) HEK293T cells. 1,10-Phenanthroline showed promising potency of suppressing pro-inflammatory cytokines in comparison to albendazole and praziquantel. Images are representative for three independently performed biological triplicates. Statistical analysis as * p < 0.05, ** p < 0.005, *** p < 0.0005, **** p < 0.00005 are compared as indicated in the figures. Images are representative for three independent biological experiments.

Article Snippet: The cysticerci were treated with the following protease inhibitors: metalloprotease inhibitor (1,10-phenanthroline), cysteine protease inhibitor [phenyl vinyl sulfone (PVS)], and serine protease inhibitor (aprotinin and 2-pyrimidine carbonitrile) and IC50 values of drugs (belinostat and irinotecan hydrochloride)., Along with this, the viable cysts were treated with albendazole sulfoxide (ABZ) (Merck, A35395) and praziquantel (PZQ) (Merck, P4668), which are drugs of choice as anthelminthic and served as a positive control.

Techniques: Gene Expression, Comparison