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adcs  (ATCC)
97
ATCC adcs
The antibody formats shown in were conjugated with MMAE, and cell binding and cytotoxicity were evaluated in HER2-positive SK-BR-3 cells. Protein concentrations are reported per molecular species (monomeric or trimeric ADC, as indicated). Where indicated, trimeric species were re-isolated by SEC before downstream assays. a, Proposed mechanism for the switchable ADC concept. Before activation, the construct is predominantly monomeric with reduced apparent binding and low payload density. Protease-triggered activation promotes assembly into a trimeric state with increased functional valency and complex-level payload density, which may enhance target-cell killing. b, Binding of monomeric and trimeric ADC species to HER2-positive SK-BR-3 cells measured by cell-based ELISA. Data are shown as mean ± s.d. from n = 3 technical replicates. c, Cytotoxic activity of <t>ADCs</t> in HER2-positive SK-BR-3 cells. Cell viability (%) was calculated as 100 × S/V, where S is the sample signal and V is the 100% viability control (cells plus medium). Data are shown as mean ± s.d. from n = 3 technical replicates.
Adcs, supplied by ATCC, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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her2 targeted adcs  (Caris Life Sciences)
86
Caris Life Sciences her2 targeted adcs
The antibody formats shown in were conjugated with MMAE, and cell binding and cytotoxicity were evaluated in HER2-positive SK-BR-3 cells. Protein concentrations are reported per molecular species (monomeric or trimeric ADC, as indicated). Where indicated, trimeric species were re-isolated by SEC before downstream assays. a, Proposed mechanism for the switchable ADC concept. Before activation, the construct is predominantly monomeric with reduced apparent binding and low payload density. Protease-triggered activation promotes assembly into a trimeric state with increased functional valency and complex-level payload density, which may enhance target-cell killing. b, Binding of monomeric and trimeric ADC species to HER2-positive SK-BR-3 cells measured by cell-based ELISA. Data are shown as mean ± s.d. from n = 3 technical replicates. c, Cytotoxic activity of <t>ADCs</t> in HER2-positive SK-BR-3 cells. Cell viability (%) was calculated as 100 × S/V, where S is the sample signal and V is the 100% viability control (cells plus medium). Data are shown as mean ± s.d. from n = 3 technical replicates.
Her2 Targeted Adcs, supplied by Caris Life Sciences, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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cytogen psma adc  (Cytogen Inc)
86
Cytogen Inc cytogen psma adc
The antibody formats shown in were conjugated with MMAE, and cell binding and cytotoxicity were evaluated in HER2-positive SK-BR-3 cells. Protein concentrations are reported per molecular species (monomeric or trimeric ADC, as indicated). Where indicated, trimeric species were re-isolated by SEC before downstream assays. a, Proposed mechanism for the switchable ADC concept. Before activation, the construct is predominantly monomeric with reduced apparent binding and low payload density. Protease-triggered activation promotes assembly into a trimeric state with increased functional valency and complex-level payload density, which may enhance target-cell killing. b, Binding of monomeric and trimeric ADC species to HER2-positive SK-BR-3 cells measured by cell-based ELISA. Data are shown as mean ± s.d. from n = 3 technical replicates. c, Cytotoxic activity of <t>ADCs</t> in HER2-positive SK-BR-3 cells. Cell viability (%) was calculated as 100 × S/V, where S is the sample signal and V is the 100% viability control (cells plus medium). Data are shown as mean ± s.d. from n = 3 technical replicates.
Cytogen Psma Adc, supplied by Cytogen Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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converter adc  (Texas Instruments)
86
Texas Instruments converter adc
The antibody formats shown in were conjugated with MMAE, and cell binding and cytotoxicity were evaluated in HER2-positive SK-BR-3 cells. Protein concentrations are reported per molecular species (monomeric or trimeric ADC, as indicated). Where indicated, trimeric species were re-isolated by SEC before downstream assays. a, Proposed mechanism for the switchable ADC concept. Before activation, the construct is predominantly monomeric with reduced apparent binding and low payload density. Protease-triggered activation promotes assembly into a trimeric state with increased functional valency and complex-level payload density, which may enhance target-cell killing. b, Binding of monomeric and trimeric ADC species to HER2-positive SK-BR-3 cells measured by cell-based ELISA. Data are shown as mean ± s.d. from n = 3 technical replicates. c, Cytotoxic activity of <t>ADCs</t> in HER2-positive SK-BR-3 cells. Cell viability (%) was calculated as 100 × S/V, where S is the sample signal and V is the 100% viability control (cells plus medium). Data are shown as mean ± s.d. from n = 3 technical replicates.
Converter Adc, supplied by Texas Instruments, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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adc 20  (Shanghai Medicilon)
86
Shanghai Medicilon adc 20
The antibody formats shown in were conjugated with MMAE, and cell binding and cytotoxicity were evaluated in HER2-positive SK-BR-3 cells. Protein concentrations are reported per molecular species (monomeric or trimeric ADC, as indicated). Where indicated, trimeric species were re-isolated by SEC before downstream assays. a, Proposed mechanism for the switchable ADC concept. Before activation, the construct is predominantly monomeric with reduced apparent binding and low payload density. Protease-triggered activation promotes assembly into a trimeric state with increased functional valency and complex-level payload density, which may enhance target-cell killing. b, Binding of monomeric and trimeric ADC species to HER2-positive SK-BR-3 cells measured by cell-based ELISA. Data are shown as mean ± s.d. from n = 3 technical replicates. c, Cytotoxic activity of <t>ADCs</t> in HER2-positive SK-BR-3 cells. Cell viability (%) was calculated as 100 × S/V, where S is the sample signal and V is the 100% viability control (cells plus medium). Data are shown as mean ± s.d. from n = 3 technical replicates.
Adc 20, supplied by Shanghai Medicilon, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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adc targets  (Ultivue Inc)
86
Ultivue Inc adc targets
The antibody formats shown in were conjugated with MMAE, and cell binding and cytotoxicity were evaluated in HER2-positive SK-BR-3 cells. Protein concentrations are reported per molecular species (monomeric or trimeric ADC, as indicated). Where indicated, trimeric species were re-isolated by SEC before downstream assays. a, Proposed mechanism for the switchable ADC concept. Before activation, the construct is predominantly monomeric with reduced apparent binding and low payload density. Protease-triggered activation promotes assembly into a trimeric state with increased functional valency and complex-level payload density, which may enhance target-cell killing. b, Binding of monomeric and trimeric ADC species to HER2-positive SK-BR-3 cells measured by cell-based ELISA. Data are shown as mean ± s.d. from n = 3 technical replicates. c, Cytotoxic activity of <t>ADCs</t> in HER2-positive SK-BR-3 cells. Cell viability (%) was calculated as 100 × S/V, where S is the sample signal and V is the 100% viability control (cells plus medium). Data are shown as mean ± s.d. from n = 3 technical replicates.
Adc Targets, supplied by Ultivue Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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adc 18  (Shanghai Medicilon)
86
Shanghai Medicilon adc 18
The antibody formats shown in were conjugated with MMAE, and cell binding and cytotoxicity were evaluated in HER2-positive SK-BR-3 cells. Protein concentrations are reported per molecular species (monomeric or trimeric ADC, as indicated). Where indicated, trimeric species were re-isolated by SEC before downstream assays. a, Proposed mechanism for the switchable ADC concept. Before activation, the construct is predominantly monomeric with reduced apparent binding and low payload density. Protease-triggered activation promotes assembly into a trimeric state with increased functional valency and complex-level payload density, which may enhance target-cell killing. b, Binding of monomeric and trimeric ADC species to HER2-positive SK-BR-3 cells measured by cell-based ELISA. Data are shown as mean ± s.d. from n = 3 technical replicates. c, Cytotoxic activity of <t>ADCs</t> in HER2-positive SK-BR-3 cells. Cell viability (%) was calculated as 100 × S/V, where S is the sample signal and V is the 100% viability control (cells plus medium). Data are shown as mean ± s.d. from n = 3 technical replicates.
Adc 18, supplied by Shanghai Medicilon, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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adc 19  (Shanghai Medicilon)
86
Shanghai Medicilon adc 19
The antibody formats shown in were conjugated with MMAE, and cell binding and cytotoxicity were evaluated in HER2-positive SK-BR-3 cells. Protein concentrations are reported per molecular species (monomeric or trimeric ADC, as indicated). Where indicated, trimeric species were re-isolated by SEC before downstream assays. a, Proposed mechanism for the switchable ADC concept. Before activation, the construct is predominantly monomeric with reduced apparent binding and low payload density. Protease-triggered activation promotes assembly into a trimeric state with increased functional valency and complex-level payload density, which may enhance target-cell killing. b, Binding of monomeric and trimeric ADC species to HER2-positive SK-BR-3 cells measured by cell-based ELISA. Data are shown as mean ± s.d. from n = 3 technical replicates. c, Cytotoxic activity of <t>ADCs</t> in HER2-positive SK-BR-3 cells. Cell viability (%) was calculated as 100 × S/V, where S is the sample signal and V is the 100% viability control (cells plus medium). Data are shown as mean ± s.d. from n = 3 technical replicates.
Adc 19, supplied by Shanghai Medicilon, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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chamber adc 2  (Camag)
86
Camag chamber adc 2
The antibody formats shown in were conjugated with MMAE, and cell binding and cytotoxicity were evaluated in HER2-positive SK-BR-3 cells. Protein concentrations are reported per molecular species (monomeric or trimeric ADC, as indicated). Where indicated, trimeric species were re-isolated by SEC before downstream assays. a, Proposed mechanism for the switchable ADC concept. Before activation, the construct is predominantly monomeric with reduced apparent binding and low payload density. Protease-triggered activation promotes assembly into a trimeric state with increased functional valency and complex-level payload density, which may enhance target-cell killing. b, Binding of monomeric and trimeric ADC species to HER2-positive SK-BR-3 cells measured by cell-based ELISA. Data are shown as mean ± s.d. from n = 3 technical replicates. c, Cytotoxic activity of <t>ADCs</t> in HER2-positive SK-BR-3 cells. Cell viability (%) was calculated as 100 × S/V, where S is the sample signal and V is the 100% viability control (cells plus medium). Data are shown as mean ± s.d. from n = 3 technical replicates.
Chamber Adc 2, supplied by Camag, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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deruxtecan adc  (Jackson Laboratory)
86
Jackson Laboratory deruxtecan adc
The antibody formats shown in were conjugated with MMAE, and cell binding and cytotoxicity were evaluated in HER2-positive SK-BR-3 cells. Protein concentrations are reported per molecular species (monomeric or trimeric ADC, as indicated). Where indicated, trimeric species were re-isolated by SEC before downstream assays. a, Proposed mechanism for the switchable ADC concept. Before activation, the construct is predominantly monomeric with reduced apparent binding and low payload density. Protease-triggered activation promotes assembly into a trimeric state with increased functional valency and complex-level payload density, which may enhance target-cell killing. b, Binding of monomeric and trimeric ADC species to HER2-positive SK-BR-3 cells measured by cell-based ELISA. Data are shown as mean ± s.d. from n = 3 technical replicates. c, Cytotoxic activity of <t>ADCs</t> in HER2-positive SK-BR-3 cells. Cell viability (%) was calculated as 100 × S/V, where S is the sample signal and V is the 100% viability control (cells plus medium). Data are shown as mean ± s.d. from n = 3 technical replicates.
Deruxtecan Adc, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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The antibody formats shown in were conjugated with MMAE, and cell binding and cytotoxicity were evaluated in HER2-positive SK-BR-3 cells. Protein concentrations are reported per molecular species (monomeric or trimeric ADC, as indicated). Where indicated, trimeric species were re-isolated by SEC before downstream assays. a, Proposed mechanism for the switchable ADC concept. Before activation, the construct is predominantly monomeric with reduced apparent binding and low payload density. Protease-triggered activation promotes assembly into a trimeric state with increased functional valency and complex-level payload density, which may enhance target-cell killing. b, Binding of monomeric and trimeric ADC species to HER2-positive SK-BR-3 cells measured by cell-based ELISA. Data are shown as mean ± s.d. from n = 3 technical replicates. c, Cytotoxic activity of ADCs in HER2-positive SK-BR-3 cells. Cell viability (%) was calculated as 100 × S/V, where S is the sample signal and V is the 100% viability control (cells plus medium). Data are shown as mean ± s.d. from n = 3 technical replicates.

Journal: bioRxiv

Article Title: De novo masking domains that gate TNF-family ligand assembly and activity

doi: 10.64898/2026.04.20.719557

Figure Lengend Snippet: The antibody formats shown in were conjugated with MMAE, and cell binding and cytotoxicity were evaluated in HER2-positive SK-BR-3 cells. Protein concentrations are reported per molecular species (monomeric or trimeric ADC, as indicated). Where indicated, trimeric species were re-isolated by SEC before downstream assays. a, Proposed mechanism for the switchable ADC concept. Before activation, the construct is predominantly monomeric with reduced apparent binding and low payload density. Protease-triggered activation promotes assembly into a trimeric state with increased functional valency and complex-level payload density, which may enhance target-cell killing. b, Binding of monomeric and trimeric ADC species to HER2-positive SK-BR-3 cells measured by cell-based ELISA. Data are shown as mean ± s.d. from n = 3 technical replicates. c, Cytotoxic activity of ADCs in HER2-positive SK-BR-3 cells. Cell viability (%) was calculated as 100 × S/V, where S is the sample signal and V is the 100% viability control (cells plus medium). Data are shown as mean ± s.d. from n = 3 technical replicates.

Article Snippet: Cell binding activity of antibodies and ADCs was evaluated using SK-BR-3 human breast cancer cells (ATCC).

Techniques: Binding Assay, Isolation, Activation Assay, Construct, Functional Assay, In-Cell ELISA, Activity Assay, Control