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Journal: American Journal of Cardiovascular Drugs

Article Title: Effect of Activated Charcoal on Mavacamten Pharmacokinetics in Healthy Participants

doi: 10.1007/s40256-024-00659-z

Figure Lengend Snippet:

Article Snippet: A PBPK model was adapted to include mechanistic absorption using Simcyp v22 M-ADAM by including mavacamten permeability across enterocytes [ ].

Techniques:

Table 2

Journal: International journal of antimicrobial agents

Article Title: Effect of reducing the paediatric stavudine dose by half: a physiologically-based pharmacokinetic model

doi: 10.1016/j.ijantimicag.2014.12.016

Figure Lengend Snippet: Table 2

Article Snippet: The PBPK model for stavudine utilises a perfusion-limited clearance consisting of 13 compartments representing various organs, as shown in , in the full advanced dissolution, absorption and metabolism (ADAM) PBPK model in Simcyp v. 14 (Simcyp Ltd., Sheffield, UK).

Techniques: Clinical Proteomics, Concentration Assay, Dissolution