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(A) Percentage of freezing detected in the cued task of the fear-conditioning assay in WT and TIMP2 KO mice (2-3 months of age, N = 12 mice per group). (B) Latency of TIMP2 KO and WT mice to fall in the <t>rotarod</t> in the fixed and (C) acceleration protocol at 4, 20 and 40 rpm (N = 12 mice per group). (D) Total distance traveled by TIMP2 KO and WT mice in the open field, as well as (E) velocity, and (F) percentage of time spent in the center of the arena (N = 11-12 mice per group). (G) Latency of TIMP2 KO and WT mice to fall in the wire test (N = 12 mice per group). (H) Time for TIMP2 KO and WT mice to descend the pole in the pole test (N = 11-12 mice per group). (I) Grip strength of the fore-, hind- and four limbs in TIMP2 KO and WT mice (N = 12 mice per group). (J) Hindlimb extension by clasping score in TIMP2 KO and WT mice (N = 10-11 mice per group). Data are represented as mean ± SEM. Student’s t -test for two-group comparisons. n.s., not significant.
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(A) Percentage of freezing detected in the cued task of the fear-conditioning assay in WT and TIMP2 KO mice (2-3 months of age, N = 12 mice per group). (B) Latency of TIMP2 KO and WT mice to fall in the <t>rotarod</t> in the fixed and (C) acceleration protocol at 4, 20 and 40 rpm (N = 12 mice per group). (D) Total distance traveled by TIMP2 KO and WT mice in the open field, as well as (E) velocity, and (F) percentage of time spent in the center of the arena (N = 11-12 mice per group). (G) Latency of TIMP2 KO and WT mice to fall in the wire test (N = 12 mice per group). (H) Time for TIMP2 KO and WT mice to descend the pole in the pole test (N = 11-12 mice per group). (I) Grip strength of the fore-, hind- and four limbs in TIMP2 KO and WT mice (N = 12 mice per group). (J) Hindlimb extension by clasping score in TIMP2 KO and WT mice (N = 10-11 mice per group). Data are represented as mean ± SEM. Student’s t -test for two-group comparisons. n.s., not significant.
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Image Search Results


(A) Percentage of freezing detected in the cued task of the fear-conditioning assay in WT and TIMP2 KO mice (2-3 months of age, N = 12 mice per group). (B) Latency of TIMP2 KO and WT mice to fall in the rotarod in the fixed and (C) acceleration protocol at 4, 20 and 40 rpm (N = 12 mice per group). (D) Total distance traveled by TIMP2 KO and WT mice in the open field, as well as (E) velocity, and (F) percentage of time spent in the center of the arena (N = 11-12 mice per group). (G) Latency of TIMP2 KO and WT mice to fall in the wire test (N = 12 mice per group). (H) Time for TIMP2 KO and WT mice to descend the pole in the pole test (N = 11-12 mice per group). (I) Grip strength of the fore-, hind- and four limbs in TIMP2 KO and WT mice (N = 12 mice per group). (J) Hindlimb extension by clasping score in TIMP2 KO and WT mice (N = 10-11 mice per group). Data are represented as mean ± SEM. Student’s t -test for two-group comparisons. n.s., not significant.

Journal: bioRxiv

Article Title: Neuronal TIMP2 regulates hippocampus-dependent plasticity and extracellular matrix complexity

doi: 10.1101/2022.12.28.522138

Figure Lengend Snippet: (A) Percentage of freezing detected in the cued task of the fear-conditioning assay in WT and TIMP2 KO mice (2-3 months of age, N = 12 mice per group). (B) Latency of TIMP2 KO and WT mice to fall in the rotarod in the fixed and (C) acceleration protocol at 4, 20 and 40 rpm (N = 12 mice per group). (D) Total distance traveled by TIMP2 KO and WT mice in the open field, as well as (E) velocity, and (F) percentage of time spent in the center of the arena (N = 11-12 mice per group). (G) Latency of TIMP2 KO and WT mice to fall in the wire test (N = 12 mice per group). (H) Time for TIMP2 KO and WT mice to descend the pole in the pole test (N = 11-12 mice per group). (I) Grip strength of the fore-, hind- and four limbs in TIMP2 KO and WT mice (N = 12 mice per group). (J) Hindlimb extension by clasping score in TIMP2 KO and WT mice (N = 10-11 mice per group). Data are represented as mean ± SEM. Student’s t -test for two-group comparisons. n.s., not significant.

Article Snippet: Balance and motor function was measured using the fixed and standard accelerated rotarod test (Med Associates, St. Albans, VT).

Techniques:

(A) Percentage of freezing detected in the cued task of the fear-conditioning assay in TIMP2 fl/fl and Syn Cre/+ ; TIMP2 fl/fl mice (2-3 months of age, N = 13-15 mice per group). (B) Latency of TIMP2 fl/fl and Syn Cre/+ ; TIMP2 fl/fl mice to fall in the rotarod in the fixed and (C) acceleration protocol at 4, 10 and 20 rpm (N = 13-15 mice per group). (D) Total distance traveled by TIMP2 fl/fl and Syn Cre/+ ; TIMP2 fl/fl mice in the open field, as well as (E) velocity, and (F) percentage of time spent in the center of the arena (N = 13-15 mice per group). (G) Latency of TIMP2 fl/fl and Syn Cre/+ ; TIMP2 fl/fl mice to fall in the wire test (N = 12-14 mice per group). (H) Time for TIMP2 fl/fl and Syn Cre/+ ; TIMP2 fl/fl mice to descend the pole in the pole test (N = 12-14 mice per group). (I) Grip strength of the fore-, hind- and four limbs in TIMP2 fl/fl and Syn Cre/+ ; TIMP2 fl/fl mice (N = 13-15 mice per group). (J) Hindlimb extension by clasping score in TIMP2 fl/fl and Syn Cre/+ ; TIMP2 fl/fl mice (N = 12-14 mice per group). Data are represented as mean ± SEM. Student’s t -test for two-group comparisons. n.s., not significant.

Journal: bioRxiv

Article Title: Neuronal TIMP2 regulates hippocampus-dependent plasticity and extracellular matrix complexity

doi: 10.1101/2022.12.28.522138

Figure Lengend Snippet: (A) Percentage of freezing detected in the cued task of the fear-conditioning assay in TIMP2 fl/fl and Syn Cre/+ ; TIMP2 fl/fl mice (2-3 months of age, N = 13-15 mice per group). (B) Latency of TIMP2 fl/fl and Syn Cre/+ ; TIMP2 fl/fl mice to fall in the rotarod in the fixed and (C) acceleration protocol at 4, 10 and 20 rpm (N = 13-15 mice per group). (D) Total distance traveled by TIMP2 fl/fl and Syn Cre/+ ; TIMP2 fl/fl mice in the open field, as well as (E) velocity, and (F) percentage of time spent in the center of the arena (N = 13-15 mice per group). (G) Latency of TIMP2 fl/fl and Syn Cre/+ ; TIMP2 fl/fl mice to fall in the wire test (N = 12-14 mice per group). (H) Time for TIMP2 fl/fl and Syn Cre/+ ; TIMP2 fl/fl mice to descend the pole in the pole test (N = 12-14 mice per group). (I) Grip strength of the fore-, hind- and four limbs in TIMP2 fl/fl and Syn Cre/+ ; TIMP2 fl/fl mice (N = 13-15 mice per group). (J) Hindlimb extension by clasping score in TIMP2 fl/fl and Syn Cre/+ ; TIMP2 fl/fl mice (N = 12-14 mice per group). Data are represented as mean ± SEM. Student’s t -test for two-group comparisons. n.s., not significant.

Article Snippet: Balance and motor function was measured using the fixed and standard accelerated rotarod test (Med Associates, St. Albans, VT).

Techniques: