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Journal: NPJ Precision Oncology
Article Title: Metabolomic and transcriptomic profiling of HNSCC identifies AMIGO2 as a therapeutic target modulating tumor microenvironment
doi: 10.1038/s41698-025-01132-z
Figure Lengend Snippet: a Differential expression profiles of 31 purine metabolism regulators in normal ( n = 44) and HNSCC samples ( n = 509) from TCGA dataset. b Univariate Cox regression analysis of 23 purine metabolism regulators in TCGA and merge-GEO datasets. c Strategy for sequencing Fadu cells treated with AB680. d Heatmap showing the gene downregulation profile following AB680 treatment. e Biological pathway analysis of Fadu cells after AB680 treatment. f Schematic diagram of the screening strategy for potential receptor-ligand genes in cell-cell communication. g Bubble plot of receptor-ligand interactions between different epithelial cells and myofibroblast, INSR+ endothelial cells, and C1QA+ macrophages. Ns: no significant difference, * P < 0.05, ** P ≤ 0.01, *** P ≤ 0.001.
Article Snippet: In addition, to inhibit NT5E enzymatic activity,
Techniques: Quantitative Proteomics, Sequencing