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Methyltransferase
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Estrogen receptor alpha is cell cycle-regulated and regulates the cell cycle in a ligand-dependent fashion
"To prevent the slight estrogenic activity of the phenol red present in complete alpha medium, we used phenol red-free improved minimum essential medium (IMEM; Invitrogen) as described previously. .. The lovastatin-mediated G 1 arrest was achieved by treating cells with 10 μM lovastatin (LKT Laboratories) in E2-free medium for 36 hours."
Comparison of Transcriptomic Profiles of MiaPaCa-2 Pancreatic Cancer Cells Treated with Different Statins
"Briefly, pure forms (≥98 %) of all commercially available statins were used: atorvastatin, lovastatin, simvastatin, fluvastatin, cerivastatin, pravastatin, rosuvastatin, and pitavastatin (LKT Laboratories, USA). .. Human pancreatic cancer cells MiaPaCa-2 (ATCC, Manassas, VA) were cultured in DMEM medium (Sigma Aldrich, Germany) supplemented with 10 % fetal bovine serum."
Statins repress needle-like carbon nanotube- or cholesterol crystal-stimulated IL-1β production by inhibiting the uptake of crystals by macrophages.
"Statins are 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors that lower atherogenic LDL-cholesterol levels.. Statins exert clinically relevant anti-inflammatory effects; however, the underlying molecular mechanism remains unclear.. Studies have shown that endogenous and exogenous pathogenic crystals, such as cholesterol and monosodium urate (MSU), and needle-like nanomaterials, such as multi-wall carbon nanotubes (MWCNT), induce the production of IL-1β and play a critical role in the development of crystal-associated sterile inflammatory pathologies. .. Statins are 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors that lower atherogenic LDL-cholesterol levels.. Statins exert clinically relevant anti-inflammatory effects; however, the underlying molecular mechanism remains unclear.. Studies have shown that endogenous and exogenous pathogenic crystals, such as cholesterol and monosodium urate (MSU), and needle-like nanomaterials, such as multi-wall carbon nanotubes (MWCNT), induce the production of IL-1β and play a critical role in the development of crystal-associated sterile inflammatory pathologies."
Response Predictive Markers and Synergistic Agents for Drug Repositioning of Statins in Ovarian Cancer
"Simvastatin (S6196) was purchased from Sigma-Aldrich (St. Louis, MO, USA), and lovastatin was purchased from LKT Laboratories, Inc. (St. Paul, MN, USA). .. Simvastatin and lovastatin were suspended in dimethyl sulfoxide (DMSO) (Merck Millipore, Waltham, MA, USA) and used at a concentration of 0–100 μM for the determination of IC 50 ."

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