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Image Search Results


TA inhibited OGD/R-induced pyroptosis by activating mitophagy in BV2 cells. A BV2 cells were subjected to OGD/R and treated with or wthout TA, then cell viability were detected by MTT.*** p < 0.001 versus OGD/R alone group, n = 3. B BV2 cells were subjected to OGD/R and treated either TA or TA combined with mitophagy inhibitor AC220, then cell viability was detected by MTT. ** p < 0.01 and *** p < 0.001 versus the corresponding group, n = 3. C Representative images of Hoechst and PI staining in BV2 cells subjected to OGD/R and treated with either TA or TA combined with AC220. Magnification: × 10; scale bar: 100 μm. D The Western blotting detection of the protein expressions of NLRP3 and GSDMD in BV2 cells subjected to OGD/R and treated with either TA or TA combined with atophagy inhibitor 3MA. E The bar chart indicates the rate of PI/Hoechst in BV2 cells. *** p < 0.001, n = 3. F , G The bar chart presents the ratios of NLRP3/β-actin, N-GSDMD/β-actin. * p < 0.05 and *** p < 0.001versus the corresponding group, n = 3. H Representative images of BV2 cells transfected with EGFP-NLRP3, EGFP-Caspase-1 or mCherry-ASC plasmid and subjected to OGD/R and treated with either TA or TA combined with AC220. Magnification: × 10, scale bar: 100 μm. I BV2 cells were subjected to OGD/R and treated with or without TA, immunofluorescence staining was used to observe the co-localization of LC3 and NLRP3, and fluorescence images were collected. Magnification: × 64, scale bar: 5 μm. J – L The bar chart presents the ratios of EGFP-NLRP3/Hoechst, EGFP-Caspase-1/Hoechst or mCherry-ASC/Hoechst in BV2 cells of different groups. * p < 0.05, ** p < 0.01 and *** p < 0.001, n = 3

Journal: Chinese Medicine

Article Title: Thonningianin A derived from Penthorum chinense Pursh alleviates cerebral ischemia/reperfusion-mediated apoptosis and pyroptosis through the activation of PINK1/Parkin-dependent mitophagy

doi: 10.1186/s13020-025-01247-2

Figure Lengend Snippet: TA inhibited OGD/R-induced pyroptosis by activating mitophagy in BV2 cells. A BV2 cells were subjected to OGD/R and treated with or wthout TA, then cell viability were detected by MTT.*** p < 0.001 versus OGD/R alone group, n = 3. B BV2 cells were subjected to OGD/R and treated either TA or TA combined with mitophagy inhibitor AC220, then cell viability was detected by MTT. ** p < 0.01 and *** p < 0.001 versus the corresponding group, n = 3. C Representative images of Hoechst and PI staining in BV2 cells subjected to OGD/R and treated with either TA or TA combined with AC220. Magnification: × 10; scale bar: 100 μm. D The Western blotting detection of the protein expressions of NLRP3 and GSDMD in BV2 cells subjected to OGD/R and treated with either TA or TA combined with atophagy inhibitor 3MA. E The bar chart indicates the rate of PI/Hoechst in BV2 cells. *** p < 0.001, n = 3. F , G The bar chart presents the ratios of NLRP3/β-actin, N-GSDMD/β-actin. * p < 0.05 and *** p < 0.001versus the corresponding group, n = 3. H Representative images of BV2 cells transfected with EGFP-NLRP3, EGFP-Caspase-1 or mCherry-ASC plasmid and subjected to OGD/R and treated with either TA or TA combined with AC220. Magnification: × 10, scale bar: 100 μm. I BV2 cells were subjected to OGD/R and treated with or without TA, immunofluorescence staining was used to observe the co-localization of LC3 and NLRP3, and fluorescence images were collected. Magnification: × 64, scale bar: 5 μm. J – L The bar chart presents the ratios of EGFP-NLRP3/Hoechst, EGFP-Caspase-1/Hoechst or mCherry-ASC/Hoechst in BV2 cells of different groups. * p < 0.05, ** p < 0.01 and *** p < 0.001, n = 3

Article Snippet: Rap (T1537), AC220 (T2066) and 3MA (T1879) were purchased from TargetMol (Shanghai, China).

Techniques: Staining, Western Blot, Transfection, Plasmid Preparation, Immunofluorescence, Fluorescence