Journal: Acta Medica Lituanica

Article Title: Ankle and Distal Tibia Megaprostheses in Orthopedic Oncology: A Report of Two Cases and Review of the Literature

doi: 10.15388/Amed.2024.31.2.13

Figure Lengend Snippet: Intraoperative images showing (A) the distal tibia surgical specimen after resection and (B) the resulting bone gap, which was later fulfilled with (C) our custom made prosthetic implant.

Article Snippet: The bone defect was fulfilled with a 3D-printed custom-made distal tibia prosthesis consisting of a Ti6AL4V alloy with a TrabecuLink structure on its bone contact surfaces (Waldemar Link GmbH & Co., Hamburg, Germany), which was fixed to the remaining autograft and native tibia using custom made medial and anterior plates designed to avoid screw colliding in the tibial shaft.

Techniques:

Journal: Acta Medica Lituanica

Article Title: Ankle and Distal Tibia Megaprostheses in Orthopedic Oncology: A Report of Two Cases and Review of the Literature

doi: 10.15388/Amed.2024.31.2.13

Figure Lengend Snippet: Intraoperative images showing (A) the distal tibia surgical specimen after resection and (B) the resulting bone gap, which was later fulfilled with (C) our custom made prosthetic implant.

Article Snippet: The bone defect was fulfilled with a 3D-printed custom-made distal tibia prosthesis consisting of a Ti6AL4V alloy with a TrabecuLink structure on its bone contact surfaces (Waldemar Link GmbH & Co., Hamburg, Germany), which was fixed to the native tibia with an uncemented stem ( ).

Techniques:

Journal: Frontiers in Bioengineering and Biotechnology

Article Title: Design and validation of a novel 3D-printed glenohumeral fusion prosthesis for the reconstruction of proximal humerus bone defects: a biomechanical study

doi: 10.3389/fbioe.2024.1428446

Figure Lengend Snippet: Design of the 3D-printed glenohumeral fusion prosthesis and model construction, and element division method and loading modes in the finite element analysis. (A,B) Design details of the 3D-printed glenohumeral fusion prosthesis. (C) Biomimetic bones (sawbones) of the shoulder joint were used to construct biomechanical experimental models for simulating proximal humerus bone defect reconstruction after proximal humerus tumor resection with the 3D-printed glenohumeral fusion prosthesis. (D–F) Three reconstruction models were created, all of which simulated the reconstruction of the bone defect after a 15-cm osteotomy in the proximal humerus. (D) Model 1 represented traditional glenohumeral arthrodesis with an intercalary allograft and a vascularized fibular graft. (E) Model 2 represented the 3D-printed glenohumeral fusion prosthesis. (F) Model 3 represented the 3D-printed glenohumeral fusion prosthesis with a metal plate fixed on the spine of the scapula. (G) The contact was set, and the grid was divided freely with solid 187 as the solid unit and 3 mm as the unit size. (H,I) The scapula was bound and fixed, and two loading modes were applied to the distal end of the humerus. (H) The first loading mode consisted of an axial load of 700 N along the humeral axis, which was equivalent to the pressure on the glenohumeral joint during arm elevation (Model 1 is taken as an example to illustrate two loading modes). (I) The loading mode consisted of a vertical downward load of 42.532 N, which was equivalent to the weight of the upper limb.

Article Snippet: The 3D-printed glenohumeral fusion prosthesis was fabricated by Arcam Q10 PLUS (Arcam Inc., Germany) using high-energy electron beam melting (EBM) technology.

Techniques: Construct

Journal: Frontiers in Bioengineering and Biotechnology

Article Title: Design and validation of a novel 3D-printed glenohumeral fusion prosthesis for the reconstruction of proximal humerus bone defects: a biomechanical study

doi: 10.3389/fbioe.2024.1428446

Figure Lengend Snippet: Two reconstruction models in the biomechanical experiment verification, and the total displacement of the prosthesis and the maximum principal strain of the glenoid cavity at an axial downward pressure of 700 N in the biomechanical experiment. (A,C) The reconstruction model using the 3D-printed glenohumeral fusion prosthesis with a lateral metal plate fixed on the spine of the scapula (with-plate group); (B,D) The reconstruction model using the 3D-printed glenohumeral fusion prosthesis only (without-plate group). (E) The total displacement of the prosthesis in the with-plate group. (F) The total displacement of the prosthesis in the without-plate group. (G) The maximum principal strain of the glenoid cavity in the with-plate group. (H) The maximum principal strain of the glenoid cavity in the without-plate group.

Article Snippet: The 3D-printed glenohumeral fusion prosthesis was fabricated by Arcam Q10 PLUS (Arcam Inc., Germany) using high-energy electron beam melting (EBM) technology.

Techniques:

Journal: Materials Today Bio

Article Title: A multifunctional ionic liquid coating on 3D-Printed prostheses: Combating infection, promoting osseointegration

doi: 10.1016/j.mtbio.2024.101076

Figure Lengend Snippet: Ionic liquid-coated 3D-printed prosthesis prevents periprosthetic infection and promotes osseointegration simultaneously.

Article Snippet: The 3D-printed pTi prosthesis was manufactured by the Arcam Electron Beam Melting (EBM) system (Q10, Sweden), following the method described in our previous studies [ , , ].

Techniques: Infection

Journal: Materials Today Bio

Article Title: A multifunctional ionic liquid coating on 3D-Printed prostheses: Combating infection, promoting osseointegration

doi: 10.1016/j.mtbio.2024.101076

Figure Lengend Snippet: Elemental compositions on the prosthesis surfaces determined by EDS.

Article Snippet: The 3D-printed pTi prosthesis was manufactured by the Arcam Electron Beam Melting (EBM) system (Q10, Sweden), following the method described in our previous studies [ , , ].

Techniques:

Journal: Materials Today Bio

Article Title: A multifunctional ionic liquid coating on 3D-Printed prostheses: Combating infection, promoting osseointegration

doi: 10.1016/j.mtbio.2024.101076

Figure Lengend Snippet: In vitro NIR photothermal bactericidal activity of the pTi@MMIB. (a, b) Infrared thermographic images (a) and temperature change curves (b) of the pTi and pTi@MMIB under NIR irradiation (808 nm, 2 W cm −2 ). (c) On–off temperature curves for pTi@MMIB under NIR irradiation (808 nm, 2 W cm −2 ). (d, g) Photographs of the bacterial colonies after the standard plate count assay and SEM images of the adhered bacteria on the prosthesis surfaces. (e, h) Number of adhered bacteria on the prosthesis surfaces. (f, i) NIR photothermal bactericidal activity of pTi and pTi@MMIB. (d–f) for E. coli , (g–i) for S. aureus . n = 3, **p < 0.01, ***p < 0.001.

Article Snippet: The 3D-printed pTi prosthesis was manufactured by the Arcam Electron Beam Melting (EBM) system (Q10, Sweden), following the method described in our previous studies [ , , ].

Techniques: In Vitro, Activity Assay, Irradiation, Bacteria

Journal: Materials Today Bio

Article Title: A multifunctional ionic liquid coating on 3D-Printed prostheses: Combating infection, promoting osseointegration

doi: 10.1016/j.mtbio.2024.101076

Figure Lengend Snippet: In vivo anti-infection performance of the pTi@MMIB. (a) Temperature change of the implanting pTi and pTi@MMIB under NIR irradiation (808 nm, 2 W cm −2 ). (b) The survival of the animals during the entire experiment. (c) WBC count in the peripheral blood evaluates the severity of systemic infection (n = 5). (d) Neutrophils count in the peripheral blood after different time of treatment (n = 5). (e) IL-6 content after different time of treatment (n = 5). (f) Giemsa staining shows bacterial contamination in the tissue around the prosthesis interfaces (red arrows indicate bacteria). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)

Article Snippet: The 3D-printed pTi prosthesis was manufactured by the Arcam Electron Beam Melting (EBM) system (Q10, Sweden), following the method described in our previous studies [ , , ].

Techniques: In Vivo, Infection, Irradiation, Staining, Bacteria

Journal: Materials Today Bio

Article Title: A multifunctional ionic liquid coating on 3D-Printed prostheses: Combating infection, promoting osseointegration

doi: 10.1016/j.mtbio.2024.101076

Figure Lengend Snippet: In vivo bone regeneration and osseointegration assessment around the prosthesis interfaces. (a) Gross view of the lateral condyle of distal femurs. (b) 3D reconstruction images of the prosthesis (white) and regenerated bone tissue (yellow). (c–f) Bone morphometric analysis of bone volume/tissue volume (BV/TV) (c), trabecular number (Tb·N) (d), trabecular bone thickness (Tb·Th) (e), trabecular separation (Tb.Sp) (f) according to Micro-CT at 12 weeks post-implantation. (g) Representative histological images of Masson staining (the black areas indicate the pTi prosthesis, the blue areas indicate the bone, and the yellow areas indicate pus). (h) Biomechanical evaluation by pull-out testing to study the osseointegration between the prosthesis interfaces. (i) Representative images of calcein fluorescence double-labelling of bone regeneration around the prosthesis interfaces. (j) Mineral apposition rate (MAR) by calcein fluorescence double labelling (n = 5, *p < 0.05, **p < 0.01, ***p < 0.001). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)

Article Snippet: The 3D-printed pTi prosthesis was manufactured by the Arcam Electron Beam Melting (EBM) system (Q10, Sweden), following the method described in our previous studies [ , , ].

Techniques: In Vivo, Micro-CT, Staining, Fluorescence

Journal: Materials Today Bio

Article Title: A multifunctional ionic liquid coating on 3D-Printed prostheses: Combating infection, promoting osseointegration

doi: 10.1016/j.mtbio.2024.101076

Figure Lengend Snippet: Representative histological H&E staining images of the main organs taken from the different groups three months after prosthesis implantation.

Article Snippet: The 3D-printed pTi prosthesis was manufactured by the Arcam Electron Beam Melting (EBM) system (Q10, Sweden), following the method described in our previous studies [ , , ].

Techniques: Staining