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Efficacy comparison of selected antiviral NPs based on HS/SA mimetic structures, including a few historic examples but mostly recent formulations where EC 50 /IC 50 values or curves were available.

Journal: Smart Medicine

Article Title: Pathogen‐binding nanoparticles to inhibit host cell infection by heparan sulfate and sialic acid dependent viruses and protozoan parasites

doi: 10.1002/SMMD.20230046

Figure Lengend Snippet: Efficacy comparison of selected antiviral NPs based on HS/SA mimetic structures, including a few historic examples but mostly recent formulations where EC 50 /IC 50 values or curves were available.

Article Snippet: The same 2D graphene platform was also effective against IAV by substituting the sulfates with SA moieties.

Techniques: Comparison, Virus, Animal Model

Non‐spherical nanodesigns for virus inhibition. (A) Schematic of heparin/HS modified T1 DNA origami shells and corresponding electron micrographs showing successful caging of various virus types (Scale bar, 100 nm). Modified and reprinted under terms of the CC‐BY license. <xref ref-type= 106 Copyright 2022, The Authors, published by American Chemical Society. (B) 2D graphene nanosheets with sulfated dendritic groups and hydrophobic chains (≥10 carbons in length) achieved potent SARS‐CoV‐2 inhibition with a virucidal mechanism (bottom images show plaque assay). *** p < 0.001. Modified and reprinted under terms of the CC‐BY license. 57 Copyright 2021, The Authors, published by John Wiley and Sons. HS, heparan sulfate. " width="100%" height="100%">

Journal: Smart Medicine

Article Title: Pathogen‐binding nanoparticles to inhibit host cell infection by heparan sulfate and sialic acid dependent viruses and protozoan parasites

doi: 10.1002/SMMD.20230046

Figure Lengend Snippet: Non‐spherical nanodesigns for virus inhibition. (A) Schematic of heparin/HS modified T1 DNA origami shells and corresponding electron micrographs showing successful caging of various virus types (Scale bar, 100 nm). Modified and reprinted under terms of the CC‐BY license. 106 Copyright 2022, The Authors, published by American Chemical Society. (B) 2D graphene nanosheets with sulfated dendritic groups and hydrophobic chains (≥10 carbons in length) achieved potent SARS‐CoV‐2 inhibition with a virucidal mechanism (bottom images show plaque assay). *** p < 0.001. Modified and reprinted under terms of the CC‐BY license. 57 Copyright 2021, The Authors, published by John Wiley and Sons. HS, heparan sulfate.

Article Snippet: The same 2D graphene platform was also effective against IAV by substituting the sulfates with SA moieties.

Techniques: Virus, Inhibition, Modification, Plaque Assay