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Human cancer cell growth inhibitory activity GI 50 (nM) of 9 in NCI 60 cell line panel.

Journal: Bioorganic & medicinal chemistry letters

Article Title: Novel pyrazolo[4,3- d ]pyrimidine microtubule targeting agents (MTAs): Synthesis, structure–activity relationship, in vitro and in vivo evaluation as antitumor agents

doi: 10.1016/j.bmcl.2021.127923

Figure Lengend Snippet: Human cancer cell growth inhibitory activity GI 50 (nM) of 9 in NCI 60 cell line panel.

Article Snippet: Panel/Cell line GI 50 (nM) Panel/Cell line GI 50 (nM) Panel/Cell line GI 50 (nM) Panel/Cell line GI 50 (nM) Leukemia Colon Cancer Melanoma Renal Cancer CCRF-CEM 9.96 COLO 205 9.78 LOX IMVI 8.53 786-0 13.23 HL-60 (TB) 11.23 HCC-2998 23.56 MALME-3M 12.07 A498 13.42 K-562 6.46 HCT-116 9.07 M14 10.56 ACHN 8.40 MOLT-4 19.85 HCT-15 5.14 MDA-MB-435 3.90 CAKI-1 15.72 RPMI-8226 15.29 HT29 7.60 SK-MEL-2 20.97 RXF 393 8.75 SR 9.64 KM12 10.76 SK-MEL-28 17.04 SN12C 15.76 NSCLC SW-620 6.67 SK-MEL-5 14.58 TK-10 16.31 A549/ATCC 12.67 CNS Cancer UACC-257 22.69 UO-31 10.01 EKVX 15.47 SF-268 12.17 UACC-62 15.90 HOP-62 15.41 SF-295 11.43 Ovarian cancer Breast Cancer HOP-92 16.03 SF-539 8.76 IGROVI 13.30 MCF7 10.81 NCI-H226 9.49 SNB-19 13.88 OVCAR-3 6.37 MDA-MB-231/ATCC 14.29 NCI-H23 11.87 SNB-75 10.81 OVCAR-4 12.93 HS 578T 11.19 NCI-H322M 14.09 U251 7.97 OVCAR-5 11.76 BT-549 24.12 NCI-H460 4.52 Prostate Cancer OVCAR-8 14.69 T-47D 16.44 NCI-H522 14.43 PC-3 10.73 NCI/ADR-RES 8.24 MDA-MB-468 9.09 DU-145 8.89 SK-OV-3 13.93 Open in a separate window Human cancer cell growth inhibitory activity GI 50 (nM) of 9 in NCI 60 cell line panel.

Techniques: Activity Assay