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Institute for Clinical Pharmacodynamics web-based randomisation procedure
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Modification:

Article Title: Effect of statin use on oncologic outcomes in head and neck squamous cell carcinoma.
Article Snippet: The treatment of human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) has not changed dramatically in the last decade, and is fraught with toxicity, recurrence, and a generally poor prognosis.. The intricate anatomic nature of the region means malignant disease is often in close proximity to vital structures; damage to which during treatment threatens vitality not only in a biologic sense but also psychosocially, as these structures are crucial for communication and appearance.. Treatment toxicity is often permanent.

Article Title: From Multiple Quality Indicators of Breast Cancer Care Toward Hospital Variation of a Summary Measure.
Article Snippet: Hospitals choose to register the data themselves directly into a web-based system (20%-30% of all hospitals) provided by Dutch Institute for Clinical Auditing or have it registered by the Netherlands Comprehensive Cancer Organisation as part of the Netherlands Cancer Registry (NCR).

Article Title: Evaluation of the cost and effectiveness of diverse recruitment methods for a genetic screening study
Article Snippet: All recruitment and patient educational materials, including the web-portal, were available to potential participants in both English and Spanish and were modified to be culturally appropriate for Latino/as, under the guidance of the Community Engagement Core Resource of the Columbia University Irving Institute for Clinical and Translational Research.

Article Title: Using mHealth Tools to Improve Access and Coverage of People With Public Health Insurance and High Cardiovascular Disease Risk in Argentina: A Pragmatic Cluster Randomized Trial
Article Snippet: All educational messages were created using content that was previously validated in this population for cultural appropriateness.20 Individualized text messages were sent out to participants’ mobile phones by a web-based platform located at the Institute for Clinical Effectiveness and Health Policy in Buenos Aires, Argentina.

Article Title: Using mH ealth Tools to Improve Access and Coverage of People With Public Health Insurance and High Cardiovascular Disease Risk in Argentina: A Pragmatic Cluster Randomized Trial
Article Snippet: Individualized text messages were sent out to participants’ mobile phones by a web‐based platform located at the Institute for Clinical Effectiveness and Health Policy in Buenos Aires, Argentina.

Article Title: Uptake of Colorectal Cancer Screening by Physicians Is Associated With Greater Uptake by Their Patients.
Article Snippet: This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record.. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article.. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

Clinical Proteomics:

Article Title: Effect of statin use on oncologic outcomes in head and neck squamous cell carcinoma.
Article Snippet: The treatment of human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) has not changed dramatically in the last decade, and is fraught with toxicity, recurrence, and a generally poor prognosis.. The intricate anatomic nature of the region means malignant disease is often in close proximity to vital structures; damage to which during treatment threatens vitality not only in a biologic sense but also psychosocially, as these structures are crucial for communication and appearance.. Treatment toxicity is often permanent.

Article Title: From Multiple Quality Indicators of Breast Cancer Care Toward Hospital Variation of a Summary Measure.
Article Snippet: Hospitals choose to register the data themselves directly into a web-based system (20%-30% of all hospitals) provided by Dutch Institute for Clinical Auditing or have it registered by the Netherlands Comprehensive Cancer Organisation as part of the Netherlands Cancer Registry (NCR).

Article Title: Evaluation of the cost and effectiveness of diverse recruitment methods for a genetic screening study
Article Snippet: All recruitment and patient educational materials, including the web-portal, were available to potential participants in both English and Spanish and were modified to be culturally appropriate for Latino/as, under the guidance of the Community Engagement Core Resource of the Columbia University Irving Institute for Clinical and Translational Research.

Article Title: Using mHealth Tools to Improve Access and Coverage of People With Public Health Insurance and High Cardiovascular Disease Risk in Argentina: A Pragmatic Cluster Randomized Trial
Article Snippet: All educational messages were created using content that was previously validated in this population for cultural appropriateness.20 Individualized text messages were sent out to participants’ mobile phones by a web-based platform located at the Institute for Clinical Effectiveness and Health Policy in Buenos Aires, Argentina.

Article Title: Using mH ealth Tools to Improve Access and Coverage of People With Public Health Insurance and High Cardiovascular Disease Risk in Argentina: A Pragmatic Cluster Randomized Trial
Article Snippet: Individualized text messages were sent out to participants’ mobile phones by a web‐based platform located at the Institute for Clinical Effectiveness and Health Policy in Buenos Aires, Argentina.

Article Title: Uptake of Colorectal Cancer Screening by Physicians Is Associated With Greater Uptake by Their Patients.
Article Snippet: This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record.. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article.. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.



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a , Schematic of the CRISPR–Cas9 knockout strategy targeting slc45a2 , designed to induce a visible pigmentation-loss phenotype for screening. Representative brightfield images of 6 and 21 dpf WT and cr slc45a2 zebrafish show loss of melanin pigmentation in mutants. b , Schematic of CRISPR guide RNA target sites (aa and ab) on the slc45a2 gene with representative Sanger sequencing traces and ICE analysis of indels from 7 dpf larvae injected at the one-cell stage with both guides. c , Indel efficiency rates for each slc45a2 CRISPR target site. d , Schematic of CRISPR guide RNA target sites (aa and ab) on the tgr5 gene with representative Sanger sequencing traces and ICE analysis from 7 dpf larvae co-injected at the one-cell stage with tgr5 and slc45a2 guides (latter not shown). e , Indel efficiency rates for each tgr5 CRISPR target site. f , Schematic of the CRISPR target site (ab) on cyp7a1 with corresponding Sanger sequencing traces and ICE analysis from 7 dpf larvae co-injected at the one-cell stage with cyp7a1 and slc45a2 guides (latter not shown). g , Indel efficiency rates for the cyp7a1 CRISPR target site. h-k , Biometrics of body length ( h , standard length, SL), muscle width ( i ), liver size ( j ) and adipose tissue size ( k ) in WT cr slc45a2 , WT cr tgr5 and WT cr cyp7a1 zebrafish at 21 dpf. l , Heat map of selected adipogenic, lipolytic, myogenic, proteolytic and inflammatory gene expression profiles in pooled WT, crslc45a2 , crtgr5 and crcyp7a1 zebrafish at 21 dpf, determined by bulk RNA-seq (n = 4 samples of 5 fish per condition). All data are mean ± s.e.m. P values were determined by one-way ANOVA with Tukey’s multiple-comparisons test ( h,i ) and Kruskal–Wallis test with Dunn’s multiple-comparisons post hoc adjustment ( j,k ). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

Journal: bioRxiv

Article Title: YAP disrupts bile acid homeostasis to drive cancer-associated cachexia

doi: 10.64898/2026.02.01.702698

Figure Lengend Snippet: a , Schematic of the CRISPR–Cas9 knockout strategy targeting slc45a2 , designed to induce a visible pigmentation-loss phenotype for screening. Representative brightfield images of 6 and 21 dpf WT and cr slc45a2 zebrafish show loss of melanin pigmentation in mutants. b , Schematic of CRISPR guide RNA target sites (aa and ab) on the slc45a2 gene with representative Sanger sequencing traces and ICE analysis of indels from 7 dpf larvae injected at the one-cell stage with both guides. c , Indel efficiency rates for each slc45a2 CRISPR target site. d , Schematic of CRISPR guide RNA target sites (aa and ab) on the tgr5 gene with representative Sanger sequencing traces and ICE analysis from 7 dpf larvae co-injected at the one-cell stage with tgr5 and slc45a2 guides (latter not shown). e , Indel efficiency rates for each tgr5 CRISPR target site. f , Schematic of the CRISPR target site (ab) on cyp7a1 with corresponding Sanger sequencing traces and ICE analysis from 7 dpf larvae co-injected at the one-cell stage with cyp7a1 and slc45a2 guides (latter not shown). g , Indel efficiency rates for the cyp7a1 CRISPR target site. h-k , Biometrics of body length ( h , standard length, SL), muscle width ( i ), liver size ( j ) and adipose tissue size ( k ) in WT cr slc45a2 , WT cr tgr5 and WT cr cyp7a1 zebrafish at 21 dpf. l , Heat map of selected adipogenic, lipolytic, myogenic, proteolytic and inflammatory gene expression profiles in pooled WT, crslc45a2 , crtgr5 and crcyp7a1 zebrafish at 21 dpf, determined by bulk RNA-seq (n = 4 samples of 5 fish per condition). All data are mean ± s.e.m. P values were determined by one-way ANOVA with Tukey’s multiple-comparisons test ( h,i ) and Kruskal–Wallis test with Dunn’s multiple-comparisons post hoc adjustment ( j,k ). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

Article Snippet: Indels in the sequenced data were analysed using the Inference of CRISPR Edits (ICE) web-based platform (Synthego).

Techniques: CRISPR, Knock-Out, Sequencing, Injection, Gene Expression, RNA Sequencing