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d trp 8 γ msh (Biosynth Carbosynth)

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Biosynth Carbosynth d trp 8 γ msh
D Trp 8 γ Msh, supplied by Biosynth Carbosynth, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/triptolide/Triptolide/pmc09687446-69-7-13
Average 90 stars, based on 1 article reviews

d trp 8 γ msh - by Bioz Stars, 2026-10

90/100 stars

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Article Title: Modulation of Canine Melanocortin-3 and -4 Receptors by Melanocortin-2 Receptor Accessory Protein 1 and 2
Article Snippet: [Nle 4 ,D-Phe 7 ]-α-MSH (NDP-MSH) and D-Trp 8 -γ-MSH were obtained from Vivitide (Louisville, KY, USA).

Article Title: Functional Characterization of Nine Novel Naturally Occurring Human Melanocortin-3 Receptor Mutations
Article Snippet: [Nle 4 , d -Phe 7 ]-α-MSH (NDP-MSH) was purchased from Bachem (King of Prussia, PA). α-MSH was purchased from Phoenix Pharmaceuticals (Belmont, CA). d -Trp 8 -γ-MSH was obtained from Peptides International (Louisville, KY).

Article Title: Fluorescence polarization assay and inhibitor design for MDM2/p53 interaction.
Article Snippet: MDM2 is an important negative regulator of the tumor suppressor protein p53 which regulates the expression of many genes including MDM2.. The delicate balance of this autoregulatory loop is crucial for the maintenance of the genome and control of the cell cycle and apoptosis.. MDM2 hyperactivity, due to amplification/overexpression or mutational inactivation of the ARF locus, inhibits the function of wild-type p53 and can lead to the development of a wide variety of cancers.

Synthesized:

Article Title: Functions of Acidic Transmembrane Residues in Human Melanocortin-3 Receptor Binding and Activation
Article Snippet: Hormones and supplies NDP-MSH was purchased from Bachem (King of Prussia, PA). α- and γ-MSH were purchased from Phoenix Pharmaceuticals (Belmont, CA). .. D -Trp 8 -γ-MSH was synthesized by Peptides International (Louisville, KY). ..

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Triptolide promotes the clearance of intracellular SA and MRSA. (A) Schematic diagram of the procedure for screening TCM monomers that modulate intracellular SA clearance. (B) Representative results illustrating the effects of 15 TCM monomers that promoted intracellular SA clearance and 2 that inhibited it. DMSO and methicillin were used as the negative and positive controls, respectively. Intracellular survival analysis of SA (C) and MRSA (D) in iBMDMs treated with different concentrations of the designated TCM monomers. Data are shown as mean ± SEM [n = 3 in (B–D) ]. ***0.0001 ≤ P < 0.001; **** P < 0.0001 [one-way ANOVA with Dunnett’s post hoc test for (B–D) ].

Journal: Frontiers in Pharmacology

Article Title: Triptolide clears Staphylococcus aureus infection by targeting XIAP to induce host apoptosis while maintaining gut microbiota homeostasis

doi: 10.3389/fphar.2026.1834558

Figure Lengend Snippet: Triptolide promotes the clearance of intracellular SA and MRSA. (A) Schematic diagram of the procedure for screening TCM monomers that modulate intracellular SA clearance. (B) Representative results illustrating the effects of 15 TCM monomers that promoted intracellular SA clearance and 2 that inhibited it. DMSO and methicillin were used as the negative and positive controls, respectively. Intracellular survival analysis of SA (C) and MRSA (D) in iBMDMs treated with different concentrations of the designated TCM monomers. Data are shown as mean ± SEM [n = 3 in (B–D) ]. ***0.0001 ≤ P < 0.001; **** P < 0.0001 [one-way ANOVA with Dunnett’s post hoc test for (B–D) ].

Article Snippet: For transcriptomics analysis, total RNA was extracted from iBMDMs infected with SA and treated with DMSO or triptolide, and from lung macrophages of mice infected with SA or MRSA treated with PBS, triptolide, or methicillin according to the TRIzol® manual (Life Technologies, 15596-026).

Techniques:

Triptolide triggers activation of the apoptotic signaling pathway. Gene Ontology (GO) enrichment analysis of differentially expressed genes (A) and proteins (B) in SA-infected iBMDMs treated with triptolide versus DMSO. Volcano maps depicting differentially expressed genes (C) and proteins (D) in SA-infected iBMDMs treated with triptolide versus DMSO. (E) Representative results of fluorescence-activated cell sorting (FACS)-based analysis for percentages of apoptotic cells. Quantification of apoptosis in SA (F) - and MRSA (G) -infected cells treated with DMSO, triptolide, or methicillin. Immunoblotting analysis of cleaved caspase-3 in SA (H) - and MRSA (I) -infected cells treated with DMSO, triptolide, or methicillin. Q-VD-OPh was used as the caspase inhibitor. Data are shown as mean ± SEM [n = 4 in (F,G) ]. **** P < 0.0001 [two-way ANOVA with Tukey’s post-hoc test for (F,G) ].

Journal: Frontiers in Pharmacology

Article Title: Triptolide clears Staphylococcus aureus infection by targeting XIAP to induce host apoptosis while maintaining gut microbiota homeostasis

doi: 10.3389/fphar.2026.1834558

Figure Lengend Snippet: Triptolide triggers activation of the apoptotic signaling pathway. Gene Ontology (GO) enrichment analysis of differentially expressed genes (A) and proteins (B) in SA-infected iBMDMs treated with triptolide versus DMSO. Volcano maps depicting differentially expressed genes (C) and proteins (D) in SA-infected iBMDMs treated with triptolide versus DMSO. (E) Representative results of fluorescence-activated cell sorting (FACS)-based analysis for percentages of apoptotic cells. Quantification of apoptosis in SA (F) - and MRSA (G) -infected cells treated with DMSO, triptolide, or methicillin. Immunoblotting analysis of cleaved caspase-3 in SA (H) - and MRSA (I) -infected cells treated with DMSO, triptolide, or methicillin. Q-VD-OPh was used as the caspase inhibitor. Data are shown as mean ± SEM [n = 4 in (F,G) ]. **** P < 0.0001 [two-way ANOVA with Tukey’s post-hoc test for (F,G) ].

Techniques: Activation Assay, Infection, Fluorescence, FACS, Western Blot

Triptolide induces apoptosis through targeting XIAP. (A) Measurement of triptolide binding affinity to Bcl2, STAT1, and XIAP by octet. (B) Molecular docking analysis between triptolide and XIAP. The BIR2 and BIR3 domains of XIAP are shown in orange. RMSD (C) and Rg (D) curves depicting the interaction between triptolide and XIAP. RMSD, root mean square deviation; Rg, radius of gyration. (E) Blocking assay to assess the effect of triptolide or SM-164 on XIAP-caspase-3/9 interaction. Quantification of apoptosis in SA (F) - and MRSA (G) -infected cells treated with DMSO, triptolide, SM-164, triptolide in combination with SM-164, or methicillin. Data are shown as mean ± SEM [n = 3 in (F,G) ]. **0.001 ≤ P < 0.01; ***0.0001 ≤ P < 0.001; **** P < 0.0001 [one-way ANOVA with Dunnett’s post hoc test for (F,G) ].

Journal: Frontiers in Pharmacology

Article Title: Triptolide clears Staphylococcus aureus infection by targeting XIAP to induce host apoptosis while maintaining gut microbiota homeostasis

doi: 10.3389/fphar.2026.1834558

Figure Lengend Snippet: Triptolide induces apoptosis through targeting XIAP. (A) Measurement of triptolide binding affinity to Bcl2, STAT1, and XIAP by octet. (B) Molecular docking analysis between triptolide and XIAP. The BIR2 and BIR3 domains of XIAP are shown in orange. RMSD (C) and Rg (D) curves depicting the interaction between triptolide and XIAP. RMSD, root mean square deviation; Rg, radius of gyration. (E) Blocking assay to assess the effect of triptolide or SM-164 on XIAP-caspase-3/9 interaction. Quantification of apoptosis in SA (F) - and MRSA (G) -infected cells treated with DMSO, triptolide, SM-164, triptolide in combination with SM-164, or methicillin. Data are shown as mean ± SEM [n = 3 in (F,G) ]. **0.001 ≤ P < 0.01; ***0.0001 ≤ P < 0.001; **** P < 0.0001 [one-way ANOVA with Dunnett’s post hoc test for (F,G) ].

Techniques: Binding Assay, Blocking Assay, Infection

Triptolide reduces SA and MRSA survival and attenuates host inflammatory pathology in vivo (A) Diagram of the experimental design in mice. Bacterial loads of SA (B) and MRSA (C) in the lungs of C57BL/6N mice treated with PBS, triptolide, or methicillin. (D) Representative images and quantitation for inflammatory areas in the lungs of C57BL/6N mice treated as in (B,C) . Scale bar, 100 μm. (E) Immunofluorescence and quantitation for cleaved caspase-3 (red) in the lung macrophages (green) of C57BL/6N mice treated as in (B,C) . Scale bar, 20 μm. Data are shown as mean ± SEM [n = 4 in (B–E) ]. *0.01 ≤ P < 0.5; **0.001 ≤ P < 0.01; ***0.0001 ≤ P < 0.001; **** P < 0.0001 [one-way ANOVA with Tukey’s post-hoc test for (B–E) ].

Journal: Frontiers in Pharmacology

Article Title: Triptolide clears Staphylococcus aureus infection by targeting XIAP to induce host apoptosis while maintaining gut microbiota homeostasis

doi: 10.3389/fphar.2026.1834558

Figure Lengend Snippet: Triptolide reduces SA and MRSA survival and attenuates host inflammatory pathology in vivo (A) Diagram of the experimental design in mice. Bacterial loads of SA (B) and MRSA (C) in the lungs of C57BL/6N mice treated with PBS, triptolide, or methicillin. (D) Representative images and quantitation for inflammatory areas in the lungs of C57BL/6N mice treated as in (B,C) . Scale bar, 100 μm. (E) Immunofluorescence and quantitation for cleaved caspase-3 (red) in the lung macrophages (green) of C57BL/6N mice treated as in (B,C) . Scale bar, 20 μm. Data are shown as mean ± SEM [n = 4 in (B–E) ]. *0.01 ≤ P < 0.5; **0.001 ≤ P < 0.01; ***0.0001 ≤ P < 0.001; **** P < 0.0001 [one-way ANOVA with Tukey’s post-hoc test for (B–E) ].

Techniques: In Vivo, Quantitation Assay, Immunofluorescence

Transcriptomics and proteomics analysis revealing that triptolide induces apoptosis in lung macrophages from mice infected with SA or MRSA. (A) GO enrichment analysis of differentially expressed genes in SA-infected mice treated with PBS, triptolide, or methicillin. (B) GO enrichment analysis of differentially expressed genes in MRSA-infected mice treated with PBS, triptolide, or methicillin. (C) GO enrichment analysis of differentially expressed proteins in mice treated as in (A) . (D) GO enrichment analysis of differentially expressed proteins in mice treated as in (B) .

Journal: Frontiers in Pharmacology

Article Title: Triptolide clears Staphylococcus aureus infection by targeting XIAP to induce host apoptosis while maintaining gut microbiota homeostasis

doi: 10.3389/fphar.2026.1834558

Figure Lengend Snippet: Transcriptomics and proteomics analysis revealing that triptolide induces apoptosis in lung macrophages from mice infected with SA or MRSA. (A) GO enrichment analysis of differentially expressed genes in SA-infected mice treated with PBS, triptolide, or methicillin. (B) GO enrichment analysis of differentially expressed genes in MRSA-infected mice treated with PBS, triptolide, or methicillin. (C) GO enrichment analysis of differentially expressed proteins in mice treated as in (A) . (D) GO enrichment analysis of differentially expressed proteins in mice treated as in (B) .

Techniques: Transcriptomics, Infection

Metagenomics analysis revealing that triptolide maintains microbiota homeostasis in mice infected with SA or MRSA. (A) Alpha (α) diversity among SA-infected mice treated with PBS, triptolide, or methicillin. (B) Alpha (α) diversity among MRSA-infected mice treated with PBS, triptolide, or methicillin. (C) Differential analysis of gut microbial composition among SA-infected mice treated as in (A) . (D) Differential analysis of gut microbial composition among MRSA-infected mice treated as in (B) .

Journal: Frontiers in Pharmacology

Article Title: Triptolide clears Staphylococcus aureus infection by targeting XIAP to induce host apoptosis while maintaining gut microbiota homeostasis

doi: 10.3389/fphar.2026.1834558

Figure Lengend Snippet: Metagenomics analysis revealing that triptolide maintains microbiota homeostasis in mice infected with SA or MRSA. (A) Alpha (α) diversity among SA-infected mice treated with PBS, triptolide, or methicillin. (B) Alpha (α) diversity among MRSA-infected mice treated with PBS, triptolide, or methicillin. (C) Differential analysis of gut microbial composition among SA-infected mice treated as in (A) . (D) Differential analysis of gut microbial composition among MRSA-infected mice treated as in (B) .

Techniques: Metagenomics, Infection

Metabolomics analysis revealing that triptolide enhances immunomodulatory metabolites against infections. (A) Partial least-squares discriminant analysis (PLS-DA) score plots of metabolites from SA-infected mice treated with PBS, triptolide, or methicillin. (B) PLS-DA score plots of metabolites from MRSA-infected mice treated with PBS, triptolide, or methicillin. (C) Heatmap of differential metabolites among SA-infected mice treated as in (A) . (D) Heatmap of differential metabolites among MRSA-infected mice treated as in (B) .

Journal: Frontiers in Pharmacology

Article Title: Triptolide clears Staphylococcus aureus infection by targeting XIAP to induce host apoptosis while maintaining gut microbiota homeostasis

doi: 10.3389/fphar.2026.1834558

Figure Lengend Snippet: Metabolomics analysis revealing that triptolide enhances immunomodulatory metabolites against infections. (A) Partial least-squares discriminant analysis (PLS-DA) score plots of metabolites from SA-infected mice treated with PBS, triptolide, or methicillin. (B) PLS-DA score plots of metabolites from MRSA-infected mice treated with PBS, triptolide, or methicillin. (C) Heatmap of differential metabolites among SA-infected mice treated as in (A) . (D) Heatmap of differential metabolites among MRSA-infected mice treated as in (B) .

Techniques: Infection

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