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Analysis of nerve sensory and motor function recovery. (A) Latency at different time points of the injured hindlimb paw in response to hot radiation stimulation measured by a <t>Hargreaves</t> test (n=4, 60 s is the threshold). (For IM+DNH/PLGA@BLZ, ***p < 0.001 vs. Sham, US+DNH/PLGA, and US+DNH/PLGA@BLZ; &p< 0.05 vs. Crush; For IM+DNH/PLGA, *p< 0.05 vs. Sham); (B) Withdrawal threshold at different time points of the injured hindlimb paw measured by the von Frey test (n=4, 2 g is the threshold). (For US+DNH/PLGA@BLZ, ###p < 0.001 vs. all other groups; For US+DNH/PLGA, *p < 0.05 vs. US+DNH/PLGA@BLZ and Sham; &&&p < 0.001: US+DNH/PLGA@BLZ and Sham vs. Crush and IM+DNH/PLGA@BLZ); (C) Representative images of mouse footprints recorded while the mice were on a walking apparatus; (D-F) Quantitative data analysis for (n=4) (D) foot pressure, (E) stance duration, and (F) swing duration based on the ratio related to the injury foot (left hind in system, LH) to the healthy foot (right hind in system, RH). (ns = no significant difference, *p < 0.05, **p < 0.01, ***p < 0.001).
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Image Search Results


Analysis of nerve sensory and motor function recovery. (A) Latency at different time points of the injured hindlimb paw in response to hot radiation stimulation measured by a Hargreaves test (n=4, 60 s is the threshold). (For IM+DNH/PLGA@BLZ, ***p < 0.001 vs. Sham, US+DNH/PLGA, and US+DNH/PLGA@BLZ; &p< 0.05 vs. Crush; For IM+DNH/PLGA, *p< 0.05 vs. Sham); (B) Withdrawal threshold at different time points of the injured hindlimb paw measured by the von Frey test (n=4, 2 g is the threshold). (For US+DNH/PLGA@BLZ, ###p < 0.001 vs. all other groups; For US+DNH/PLGA, *p < 0.05 vs. US+DNH/PLGA@BLZ and Sham; &&&p < 0.001: US+DNH/PLGA@BLZ and Sham vs. Crush and IM+DNH/PLGA@BLZ); (C) Representative images of mouse footprints recorded while the mice were on a walking apparatus; (D-F) Quantitative data analysis for (n=4) (D) foot pressure, (E) stance duration, and (F) swing duration based on the ratio related to the injury foot (left hind in system, LH) to the healthy foot (right hind in system, RH). (ns = no significant difference, *p < 0.05, **p < 0.01, ***p < 0.001).

Journal: Journal of controlled release : official journal of the Controlled Release Society

Article Title: Ultrasound-guided nanocomposite hydrogel injection to enhance nerve repair via temporal delivery of a colony-stimulating factor 1 receptor inhibitor

doi: 10.1016/j.jconrel.2026.114797

Figure Lengend Snippet: Analysis of nerve sensory and motor function recovery. (A) Latency at different time points of the injured hindlimb paw in response to hot radiation stimulation measured by a Hargreaves test (n=4, 60 s is the threshold). (For IM+DNH/PLGA@BLZ, ***p < 0.001 vs. Sham, US+DNH/PLGA, and US+DNH/PLGA@BLZ; &p< 0.05 vs. Crush; For IM+DNH/PLGA, *p< 0.05 vs. Sham); (B) Withdrawal threshold at different time points of the injured hindlimb paw measured by the von Frey test (n=4, 2 g is the threshold). (For US+DNH/PLGA@BLZ, ###p < 0.001 vs. all other groups; For US+DNH/PLGA, *p < 0.05 vs. US+DNH/PLGA@BLZ and Sham; &&&p < 0.001: US+DNH/PLGA@BLZ and Sham vs. Crush and IM+DNH/PLGA@BLZ); (C) Representative images of mouse footprints recorded while the mice were on a walking apparatus; (D-F) Quantitative data analysis for (n=4) (D) foot pressure, (E) stance duration, and (F) swing duration based on the ratio related to the injury foot (left hind in system, LH) to the healthy foot (right hind in system, RH). (ns = no significant difference, *p < 0.05, **p < 0.01, ***p < 0.001).

Article Snippet: Thermal hypersensitivity was induced by focusing infrared radiation onto the plantar skin of the hind limb paw using the Hargreaves device (Ugo Basile Thermal Plantar Test Instrument).

Techniques: