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rest  (Atlas Antibodies)


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    Structured Review

    Atlas Antibodies rest
    (A) MCF7 breast cancer cells were infected with lentivirus bearing either non-targeting control shRNA or <t>REST</t> targeting shRNA. REST knockdown was verified by western blot (Millipore antibody). Beta actin expression in shown as a loading control. (B) Paraffin-embedded MCF7 sections were stained with antibody to the <t>REST</t> <t>C-terminus</t> (Sigma) (stained brown), with hemetoxylin nuclear stain (stained blue). Control shRNA expressing cells show strong nuclear REST staining, while REST shRNA expressing cells show little to no nuclear REST staining.
    Rest, supplied by Atlas Antibodies, used in various techniques. Bioz Stars score: 85/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/rest/Anti-REST/pmc02883591-83-25-26
    Average 85 stars, based on 1 article reviews
    rest - by Bioz Stars, 2026-10
    85/100 stars

    Images

    1) Product Images from "The Transcription Factor REST Is Lost in Aggressive Breast Cancer"

    Article Title: The Transcription Factor REST Is Lost in Aggressive Breast Cancer

    Journal: PLoS Genetics

    doi: 10.1371/journal.pgen.1000979

    (A) MCF7 breast cancer cells were infected with lentivirus bearing either non-targeting control shRNA or REST targeting shRNA. REST knockdown was verified by western blot (Millipore antibody). Beta actin expression in shown as a loading control. (B) Paraffin-embedded MCF7 sections were stained with antibody to the REST C-terminus (Sigma) (stained brown), with hemetoxylin nuclear stain (stained blue). Control shRNA expressing cells show strong nuclear REST staining, while REST shRNA expressing cells show little to no nuclear REST staining.
    Figure Legend Snippet: (A) MCF7 breast cancer cells were infected with lentivirus bearing either non-targeting control shRNA or REST targeting shRNA. REST knockdown was verified by western blot (Millipore antibody). Beta actin expression in shown as a loading control. (B) Paraffin-embedded MCF7 sections were stained with antibody to the REST C-terminus (Sigma) (stained brown), with hemetoxylin nuclear stain (stained blue). Control shRNA expressing cells show strong nuclear REST staining, while REST shRNA expressing cells show little to no nuclear REST staining.

    Techniques Used: Infection, Control, shRNA, Knockdown, Western Blot, Expressing, Staining

    (A,B) Paraffin embedded breast tumor sections were immunohistochemically labeled with an antibody to the C-terminus of REST. Inset image is enlarged 2.5× to show detail. (A) Strong nuclear REST labeling in the majority of tumor cells (brown signal). (B) Weak or absent labeling for REST in REST–less tumor. (C,D) Paraffin embedded breast tumor sections were stained for the protein product of the REST target gene chromogranin-A ( CHGA ). (C) No CGA labeling detected in RESTfl tumor (blue hematoxylin stain highlights nuclei of carcinoma and stroma cells). (D) Moderate to strong labeling for CGA in a subset of carcinoma cells. The brown label (CGA) does not co-localize with the nuclear hematoxylin counterstain, suggesting a non-nuclear location. REST–less tumors were significantly enriched in chromogranin-A staining (D, p<0.001).
    Figure Legend Snippet: (A,B) Paraffin embedded breast tumor sections were immunohistochemically labeled with an antibody to the C-terminus of REST. Inset image is enlarged 2.5× to show detail. (A) Strong nuclear REST labeling in the majority of tumor cells (brown signal). (B) Weak or absent labeling for REST in REST–less tumor. (C,D) Paraffin embedded breast tumor sections were stained for the protein product of the REST target gene chromogranin-A ( CHGA ). (C) No CGA labeling detected in RESTfl tumor (blue hematoxylin stain highlights nuclei of carcinoma and stroma cells). (D) Moderate to strong labeling for CGA in a subset of carcinoma cells. The brown label (CGA) does not co-localize with the nuclear hematoxylin counterstain, suggesting a non-nuclear location. REST–less tumors were significantly enriched in chromogranin-A staining (D, p<0.001).

    Techniques Used: Labeling, Staining

    Patient outcome and tumor data corresponding to 182 paraffin embedded breast tumors stained with antibody to the REST C-terminus.
    Figure Legend Snippet: Patient outcome and tumor data corresponding to 182 paraffin embedded breast tumors stained with antibody to the REST C-terminus.

    Techniques Used: Staining

    Related Articles

    Immunohistochemical staining:

    Article Title: The Transcription Factor REST Is Lost in Aggressive Breast Cancer
    Article Snippet: .. To determine the frequency of REST protein loss in breast cancer, we developed an immunohistochemical (IHC) screen using an antibody directed to the C-terminus of REST (Atlas Antibodies, Stockholm). ..

    Article Title: The transcription factor REST is lost in aggressive breast cancer.
    Article Snippet: .. Full-length REST is lost in breast cancer To determine the frequency of REST protein loss in breast cancer, we developed an immunohistochemical (IHC) screen using an antibody directed to the C-terminus of REST (Atlas Antibodies, Stockholm). ..

    Immunohistochemistry:

    Article Title: The Transcription Factor REST Is Lost in Aggressive Breast Cancer
    Article Snippet: .. To determine the frequency of REST protein loss in breast cancer, we developed an immunohistochemical (IHC) screen using an antibody directed to the C-terminus of REST (Atlas Antibodies, Stockholm). ..

    Article Title: The transcription factor REST is lost in aggressive breast cancer.
    Article Snippet: .. Full-length REST is lost in breast cancer To determine the frequency of REST protein loss in breast cancer, we developed an immunohistochemical (IHC) screen using an antibody directed to the C-terminus of REST (Atlas Antibodies, Stockholm). ..



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    Mean trajectories (solid lines) and 95% confidence intervals (shaded areas) are shown for patients with major complications (blue) and minor or no complications (gray) across postoperative days, with values expressed as change from preoperative baseline. (A) Resting heart rate, (B) maximum pain, (C) sleep temperature, and (D) daily step count are displayed. Vertical dashed lines indicate the day of surgery (postoperative day 0). Across all metrics, patients with major complications exhibited slower and more prolonged deviations from baseline compared with patients with minor or no complications. For each postoperative day, group-level means and standard errors of the mean (SEM) were computed across all participants with available preoperative baseline values and valid daily measurements for the corresponding metric. To improve visualization of longitudinal trends, daily mean trajectories and SEM were smoothed within each complication group using a 3-point centered rolling mean (window = 3 days; minimum observations = 1).

    Journal: medRxiv

    Article Title: Wearables Anticipate Postoperative Complications: A Prospective Cohort Study

    doi: 10.64898/2026.06.02.26354556

    Figure Lengend Snippet: Mean trajectories (solid lines) and 95% confidence intervals (shaded areas) are shown for patients with major complications (blue) and minor or no complications (gray) across postoperative days, with values expressed as change from preoperative baseline. (A) Resting heart rate, (B) maximum pain, (C) sleep temperature, and (D) daily step count are displayed. Vertical dashed lines indicate the day of surgery (postoperative day 0). Across all metrics, patients with major complications exhibited slower and more prolonged deviations from baseline compared with patients with minor or no complications. For each postoperative day, group-level means and standard errors of the mean (SEM) were computed across all participants with available preoperative baseline values and valid daily measurements for the corresponding metric. To improve visualization of longitudinal trends, daily mean trajectories and SEM were smoothed within each complication group using a 3-point centered rolling mean (window = 3 days; minimum observations = 1).

    Article Snippet: In the first 10 postoperative days, peak absolute deviation from baseline was higher in the major-complication group for Garmin resting heart rate (22.2 ± 7.1 vs 14.5 ± 7.1 bpm; P=0.005, Mann–Whitney U), Oura resting heart rate (26.2 ± 12.5 vs 17.7 ± 10.1 bpm; P=0.046, Mann–Whitney U), Oura sleep temperature deviation (1.53 ± 0.81 vs 1.00 ± 0.54 °C; P=0.043, Mann–Whitney U), and Oura readiness score (43.4 ± 15.6 vs 29.7 ± 12.4; P=0.034, Welch t-test).

    Techniques:

    Boxplots show changes from preoperative baseline (median of days −10 to −1) for (A) resting heart rate, (B) maximum pain score, (C) daily step count, and (D) sleep temperature deviation at 4, 3, 2, and 1 days before complication events. Participants with major complications (Clavien–Dindo ≥IIIb; blue) were compared with those with minor or no complications (gray) using matched postoperative reference days. Line plots show postoperative trajectories expressed as change from preoperative baseline for participants with major complications (blue) and minor or no complications (gray). Vertical dashed lines indicate the day of surgery (postoperative day 0).

    Journal: medRxiv

    Article Title: Wearables Anticipate Postoperative Complications: A Prospective Cohort Study

    doi: 10.64898/2026.06.02.26354556

    Figure Lengend Snippet: Boxplots show changes from preoperative baseline (median of days −10 to −1) for (A) resting heart rate, (B) maximum pain score, (C) daily step count, and (D) sleep temperature deviation at 4, 3, 2, and 1 days before complication events. Participants with major complications (Clavien–Dindo ≥IIIb; blue) were compared with those with minor or no complications (gray) using matched postoperative reference days. Line plots show postoperative trajectories expressed as change from preoperative baseline for participants with major complications (blue) and minor or no complications (gray). Vertical dashed lines indicate the day of surgery (postoperative day 0).

    Article Snippet: In the first 10 postoperative days, peak absolute deviation from baseline was higher in the major-complication group for Garmin resting heart rate (22.2 ± 7.1 vs 14.5 ± 7.1 bpm; P=0.005, Mann–Whitney U), Oura resting heart rate (26.2 ± 12.5 vs 17.7 ± 10.1 bpm; P=0.046, Mann–Whitney U), Oura sleep temperature deviation (1.53 ± 0.81 vs 1.00 ± 0.54 °C; P=0.043, Mann–Whitney U), and Oura readiness score (43.4 ± 15.6 vs 29.7 ± 12.4; P=0.034, Welch t-test).

    Techniques: