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Insulin resistance and metabolic profile of mice treated with different carbohydrate-fat ratio diets. (A) Fasting serum insulin levels(FINS) in mice (n = 6). (B) Homeostasis Model Assessment-Insulin resistance (HOMA-IR) in mice (n = 6). (C) Triglyceride glucose (TyG) index in mice (n = 6). (D–G) Serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density cholesterol (HDL-C) levels (n = 6). (H) <t>Serum</t> <t>adiponectin</t> levels in mice (n = 6). (I) Serum <t>leptin</t> levels in mice (n = 6). (J) Serum TNF-α levels in mice (n = 6). (K) Serum IL-1β levels in mice (n = 6). (L) Serum IL-6 levels in mice (n = 6). In statistical analysis, all values are expressed as mean ± SD. In statistical analysis, all values are expressed as mean ± SD. * indicates statistical difference between the model and control groups, * P < 0.05, ** P < 0.01, *** P < 0.001.
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Insulin resistance and metabolic profile of mice treated with different carbohydrate-fat ratio diets. (A) Fasting serum insulin levels(FINS) in mice (n = 6). (B) Homeostasis Model Assessment-Insulin resistance (HOMA-IR) in mice (n = 6). (C) Triglyceride glucose (TyG) index in mice (n = 6). (D–G) Serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density cholesterol (HDL-C) levels (n = 6). (H) Serum adiponectin levels in mice (n = 6). (I) Serum leptin levels in mice (n = 6). (J) Serum TNF-α levels in mice (n = 6). (K) Serum IL-1β levels in mice (n = 6). (L) Serum IL-6 levels in mice (n = 6). In statistical analysis, all values are expressed as mean ± SD. In statistical analysis, all values are expressed as mean ± SD. * indicates statistical difference between the model and control groups, * P < 0.05, ** P < 0.01, *** P < 0.001.

Journal: Frontiers in Endocrinology

Article Title: Effects of different sugar-lipid ratio diets on the occurrence of type 2 diabetes mellitus

doi: 10.3389/fendo.2026.1768263

Figure Lengend Snippet: Insulin resistance and metabolic profile of mice treated with different carbohydrate-fat ratio diets. (A) Fasting serum insulin levels(FINS) in mice (n = 6). (B) Homeostasis Model Assessment-Insulin resistance (HOMA-IR) in mice (n = 6). (C) Triglyceride glucose (TyG) index in mice (n = 6). (D–G) Serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density cholesterol (HDL-C) levels (n = 6). (H) Serum adiponectin levels in mice (n = 6). (I) Serum leptin levels in mice (n = 6). (J) Serum TNF-α levels in mice (n = 6). (K) Serum IL-1β levels in mice (n = 6). (L) Serum IL-6 levels in mice (n = 6). In statistical analysis, all values are expressed as mean ± SD. In statistical analysis, all values are expressed as mean ± SD. * indicates statistical difference between the model and control groups, * P < 0.05, ** P < 0.01, *** P < 0.001.

Article Snippet: Additionally, serum levels of adiponectin (ED295; Lianke Bio, China) and leptin (EK-297; Lianke Bio, China) were analyzed using their respective ELISA kits.

Techniques: Control