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Shanghai Model Organisms Center map2 2 a creert mice
Map2 2 A Creert Mice, supplied by Shanghai Model Organisms Center, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/map2/basp1+cre+ert2+map2+mice/pm42029805-30-16-24
Average 86 stars, based on 1 article reviews
map2 2 a creert mice - by Bioz Stars, 2026-11
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Article Title: TDP-43 Dysfunction Causes Hyper-Lactate State, Increased AARS1 Expression and Enhanced Protein Lactylation.
Article Snippet: TAR DNA-binding protein of 43 kDa (TDP-43) is a nuclear protein encoded by the TARDBP gene.. As an RNA-binding protein, it physiologically participates in key processes such as RNA transcription, alternative splicing, and the processing of microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), playing a crucial role in maintaining cellular RNA homeostasis(Zong, Xie et al. 2024).. Studies have shown that the hallmark pathological feature of TDP-43 involves nuclear depletion and cytoplasmic aggregation, which was first identified in amyotrophic lateral sclerosis Tianshuo Zhang, Kaixin Yan contributed equally to this article.

Article Title: Macrophage-Derived Type 1 IFN, Renal Tubular Epithelial Cell Polyploidization, and AKI-to-CKD Transition
Article Snippet: .. IFN-I receptor 1 (IFNAR1) knockout ( Ifnar1 −/− ) mice, Ifnar1 flox/flox mice, and Slc34a1-cre ERT2 mice were obtained from Shanghai Model Organisms Center, Inc. (Shanghai, China). ..

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Article Title: TDP-43 Dysfunction Causes Hyper-Lactate State, Increased AARS1 Expression and Enhanced Protein Lactylation.
Article Snippet: TAR DNA-binding protein of 43 kDa (TDP-43) is a nuclear protein encoded by the TARDBP gene.. As an RNA-binding protein, it physiologically participates in key processes such as RNA transcription, alternative splicing, and the processing of microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), playing a crucial role in maintaining cellular RNA homeostasis(Zong, Xie et al. 2024).. Studies have shown that the hallmark pathological feature of TDP-43 involves nuclear depletion and cytoplasmic aggregation, which was first identified in amyotrophic lateral sclerosis Tianshuo Zhang, Kaixin Yan contributed equally to this article.



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Image Search Results


A) Viral RNA quantification in the brain. B) Heatmap showing the abundance profiles of proteins significantly altered in brain proteomics data (limma, adjusted p < 0.05) in mock versus infected samples at any of the six time points. Column annotations represent the experimental group and time point. Rows are proteins and are annotated with log2 fold-change values from differential abundance analysis at each time point. Cells corresponding to non-significant changes are shown as empty. Selected biologically relevant proteins are labeled. C ) Volcano plots of differential protein abundance at 6 dpi compared with mock samples. Key proteins are labeled. Non-significant proteins (adjusted p ≥ 0.05) are shown in grey. D ) Western blot analysis of JEV-NS1, GOT2 and ISG15 along with the HistineH3 as loading control. E ) Representative super-resolution TIRF microscopy image of infected brain tissue stained for MAP2 (red), JEV antigen (yellow) and IBA1 (cyan). Boxed regions i–iii are shown at higher magnification on the right. Scale bars, 50 µm in the overview image and 5 µm in magnified regions. F. Representative super-resolution TIRF microscopy image of infected brain tissue stained for MAP2 (red), JEV antigen (yellow) and GOT2 (green). Boxed regions i–iii are shown at higher magnification on the right. Scale bars, 50 µm in the overview image and 5 µm in magnified regions.

Journal: bioRxiv

Article Title: The mitochondrial transaminase GOT2 supports Japanese encephalitis virus replication in neuronal cells

doi: 10.64898/2026.10.12.758629

Figure Lengend Snippet: A) Viral RNA quantification in the brain. B) Heatmap showing the abundance profiles of proteins significantly altered in brain proteomics data (limma, adjusted p < 0.05) in mock versus infected samples at any of the six time points. Column annotations represent the experimental group and time point. Rows are proteins and are annotated with log2 fold-change values from differential abundance analysis at each time point. Cells corresponding to non-significant changes are shown as empty. Selected biologically relevant proteins are labeled. C ) Volcano plots of differential protein abundance at 6 dpi compared with mock samples. Key proteins are labeled. Non-significant proteins (adjusted p ≥ 0.05) are shown in grey. D ) Western blot analysis of JEV-NS1, GOT2 and ISG15 along with the HistineH3 as loading control. E ) Representative super-resolution TIRF microscopy image of infected brain tissue stained for MAP2 (red), JEV antigen (yellow) and IBA1 (cyan). Boxed regions i–iii are shown at higher magnification on the right. Scale bars, 50 µm in the overview image and 5 µm in magnified regions. F. Representative super-resolution TIRF microscopy image of infected brain tissue stained for MAP2 (red), JEV antigen (yellow) and GOT2 (green). Boxed regions i–iii are shown at higher magnification on the right. Scale bars, 50 µm in the overview image and 5 µm in magnified regions.

Article Snippet: The first cocktail included primary neuron antibody MAP2 (catalog #17490-1-AP, Proteintech) conjugated with CoraLite Plus 647 (catalog #KFA003, Proteintech) at 1:100 dilution, activated microglia antibody IBA1 (catalog #10904-1-AP, Proteintech) conjugated with CoraLite Plus 555 (catalog #KFA002, Proteintech) at 1:200 dilution, and JEV NS1 antibody (catalog #GTX633820, GneTex) conjugated with CoraLite Plus 488 (catalog #KFA521, Proteintech) at 1:500 dilution.

Techniques: Infection, Analysis, Labeling, Quantitative Proteomics, Western Blot, Control, Super Resolution, Microscopy, Tissue, Staining