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hyperoxia þ h151  (MedChemExpress)


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    Structured Review

    MedChemExpress hyperoxia þ h151
    Hyperoxia þ H151, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 99/100, based on 231 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hyperoxia/H-151/pm40938804-41-29-35
    Average 99 stars, based on 231 article reviews
    hyperoxia þ h151 - by Bioz Stars, 2026-10
    99/100 stars

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    Related Articles

    Transfection:

    Article Title: Extracellular vesicle-delivered siRNA targeting RCN1 suppresses acute myeloid leukemia through TFAM-dependent mtDNA-cGAS-STING signaling
    Article Snippet: .. Pyroptosis assay After 24 h of shNC or shRCN1 lentiviral transfection, NB4 cells were subjected to puromycin selection (2 μg·mL-1) under conditions with or without 0.5 μΜ STING inhibition (HY-112693; MedChemExpress). ..

    Selection:

    Article Title: Extracellular vesicle-delivered siRNA targeting RCN1 suppresses acute myeloid leukemia through TFAM-dependent mtDNA-cGAS-STING signaling
    Article Snippet: .. Pyroptosis assay After 24 h of shNC or shRCN1 lentiviral transfection, NB4 cells were subjected to puromycin selection (2 μg·mL-1) under conditions with or without 0.5 μΜ STING inhibition (HY-112693; MedChemExpress). ..

    Inhibition:

    Article Title: Extracellular vesicle-delivered siRNA targeting RCN1 suppresses acute myeloid leukemia through TFAM-dependent mtDNA-cGAS-STING signaling
    Article Snippet: .. Pyroptosis assay After 24 h of shNC or shRCN1 lentiviral transfection, NB4 cells were subjected to puromycin selection (2 μg·mL-1) under conditions with or without 0.5 μΜ STING inhibition (HY-112693; MedChemExpress). ..

    Cell Stimulation:

    Article Title: CDK4/MERCs/PINK1 Axis Drives PFOA/HFPO‐TA‐Induced Cardiac Senescence via Mitophagy Defect and cGAS‐STING Activation: In Vitro Amelioration by Cycloastragenol
    Article Snippet: .. For cellular stimulation, HL‐1 cells were treated with different reagents, including 20 nM Baf A1 and 1 μM H‐151 (MCE, USA). ..

    Injection:

    Article Title: Metabolic stress-activated endothelial STING rewires the sinusoidal immune niche in MASLD
    Article Snippet: The WD-CCL4-induced mice were administered intraperitoneal injections of BMP signaling inhibitor LDN-193189 (HY-12071; MedChemExpress; 3 mg/kg), BMP4 agonist SB4 (HY-124697; MedChemExpress; 3 mg/kg), or pan-BMP agonist SJ000291942 (HY-112331; MedChemExpress; 3 mg/kg) twice per week during the final 4 weeks, additionally. .. The H-151 (HY-112693; MedChemExpress; 10 mg/kg) or RLRT-Liposome@H-151 (RLH) (H-151 1 mg/kg) was injected into the WD-CCL4induced mice from week 5 to week 8. ..



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    a, Heatmap of Pearson correlations calculated between the HPCS and recurrent pan-cancer cell states (AC: astrocyte-like cell state, OPC: oligodendrocyte progenitor cell-like, NPC: neural progenitor cell-like) , divided by cancer type (BC: breast cancer, CRC: colorectal cancer, HNC: head and neck cancer, LUAD: lung adenocarcinoma, OC: ovarian cancer, PCa: prostate adenocarcinoma, PDAC: pancreatic ductal adenocarcinoma, SCC: squamous cell carcinoma of the skin, ALL: acute lymphoblastic leukemia, MM: multiple myeloma). Arrow indicates the Stress -associated cell state from ref. . A full list of studies is listed in Supplementary Table 5 . b, Pearson correlation between the HPCS signature score ( x -axis) and plastic cell states ( y -axis) from either colorectal cancer (OF/HRC: oncofetal/core high relapse , ) ( top ), and pancreatic ductal adenocarcinoma (scBasal ) ( middle ), or castration-resistant prostate cancer adenocarcinoma (Plasticity ) ( bottom ). Two-tailed p value calculated from the exact distribution of Pearson correlation coefficient. c , Heatmaps demonstrating mean gene signature score in either SLC4A11 or PLAUR negative and positive cells scaled using a z-score generated per program to compare gene signatures across different cancer types in human scRNA-seq datasets ( Supplementary Table 5 ). For each dataset gene pair, significance is calculated by comparing positive vs negative cells and depicted in the positive cell column. Four human LUAD datasets are shown [LungM 5 ; LungK ; LungB ; LungD ] along with plastic cell states [OF/HRC , , lowerSpike , Plasticity ] in other cancers [CRC ; SCC ; PCa ; PDAC ; HNC_C , HNC_K , OC ]. t-test. d, Immunofluorescence of human LUAD stained for (top) uPAR (green) and integrin α2 (red) or (bottom) pan-cytokeratin (white). Arrows point to uPAR and integrin α2 double positive cells. Scale bar: 25 μm. e, Heatmaps demonstrating mean gene signature score in either Slc4a11 or Plaur negative and positive cells scaled using a z-score generated per program to compare gene signatures across different injury models in mouse single cell datasets ( Supplementary Table 5 ). Heatmaps of signature scores represented as z-scores of the indicated regenerative programs in Lung (DATP: damage associated transient progenitor ; ADI: KRT8 + alveolar differentiation intermediate ; PATS: pre-alveolar type-1 transitional cell state ), Pancreas (scBasal cell state ), Intestine (revSC: revival stem cell ; SSC2: singly profiled stem cell cluster 2 ) and Skin (Wound ). For each dataset gene pair, significance is calculated by comparing positive vs negative cells and depicted in the positive cell column. t-test. f, Representative multiplex FISH staining of Slc4a11 (red) and Sftpc (green) in normal lungs vs. 7 days following <t>hyperoxia-induced</t> lung injury. Scale bar: 10 µm.
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    a, Heatmap of Pearson correlations calculated between the HPCS and recurrent pan-cancer cell states (AC: astrocyte-like cell state, OPC: oligodendrocyte progenitor cell-like, NPC: neural progenitor cell-like) , divided by cancer type (BC: breast cancer, CRC: colorectal cancer, HNC: head and neck cancer, LUAD: lung adenocarcinoma, OC: ovarian cancer, PCa: prostate adenocarcinoma, PDAC: pancreatic ductal adenocarcinoma, SCC: squamous cell carcinoma of the skin, ALL: acute lymphoblastic leukemia, MM: multiple myeloma). Arrow indicates the Stress -associated cell state from ref. . A full list of studies is listed in Supplementary Table 5 . b, Pearson correlation between the HPCS signature score ( x -axis) and plastic cell states ( y -axis) from either colorectal cancer (OF/HRC: oncofetal/core high relapse , ) ( top ), and pancreatic ductal adenocarcinoma (scBasal ) ( middle ), or castration-resistant prostate cancer adenocarcinoma (Plasticity ) ( bottom ). Two-tailed p value calculated from the exact distribution of Pearson correlation coefficient. c , Heatmaps demonstrating mean gene signature score in either SLC4A11 or PLAUR negative and positive cells scaled using a z-score generated per program to compare gene signatures across different cancer types in human scRNA-seq datasets ( Supplementary Table 5 ). For each dataset gene pair, significance is calculated by comparing positive vs negative cells and depicted in the positive cell column. Four human LUAD datasets are shown [LungM 5 ; LungK ; LungB ; LungD ] along with plastic cell states [OF/HRC , , lowerSpike , Plasticity ] in other cancers [CRC ; SCC ; PCa ; PDAC ; HNC_C , HNC_K , OC ]. t-test. d, Immunofluorescence of human LUAD stained for (top) uPAR (green) and integrin α2 (red) or (bottom) pan-cytokeratin (white). Arrows point to uPAR and integrin α2 double positive cells. Scale bar: 25 μm. e, Heatmaps demonstrating mean gene signature score in either Slc4a11 or Plaur negative and positive cells scaled using a z-score generated per program to compare gene signatures across different injury models in mouse single cell datasets ( Supplementary Table 5 ). Heatmaps of signature scores represented as z-scores of the indicated regenerative programs in Lung (DATP: damage associated transient progenitor ; ADI: KRT8 + alveolar differentiation intermediate ; PATS: pre-alveolar type-1 transitional cell state ), Pancreas (scBasal cell state ), Intestine (revSC: revival stem cell ; SSC2: singly profiled stem cell cluster 2 ) and Skin (Wound ). For each dataset gene pair, significance is calculated by comparing positive vs negative cells and depicted in the positive cell column. t-test. f, Representative multiplex FISH staining of Slc4a11 (red) and Sftpc (green) in normal lungs vs. 7 days following <t>hyperoxia-induced</t> lung injury. Scale bar: 10 µm.
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    a, Heatmap of Pearson correlations calculated between the HPCS and recurrent pan-cancer cell states (AC: astrocyte-like cell state, OPC: oligodendrocyte progenitor cell-like, NPC: neural progenitor cell-like) , divided by cancer type (BC: breast cancer, CRC: colorectal cancer, HNC: head and neck cancer, LUAD: lung adenocarcinoma, OC: ovarian cancer, PCa: prostate adenocarcinoma, PDAC: pancreatic ductal adenocarcinoma, SCC: squamous cell carcinoma of the skin, ALL: acute lymphoblastic leukemia, MM: multiple myeloma). Arrow indicates the Stress -associated cell state from ref. . A full list of studies is listed in Supplementary Table 5 . b, Pearson correlation between the HPCS signature score ( x -axis) and plastic cell states ( y -axis) from either colorectal cancer (OF/HRC: oncofetal/core high relapse , ) ( top ), and pancreatic ductal adenocarcinoma (scBasal ) ( middle ), or castration-resistant prostate cancer adenocarcinoma (Plasticity ) ( bottom ). Two-tailed p value calculated from the exact distribution of Pearson correlation coefficient. c , Heatmaps demonstrating mean gene signature score in either SLC4A11 or PLAUR negative and positive cells scaled using a z-score generated per program to compare gene signatures across different cancer types in human scRNA-seq datasets ( Supplementary Table 5 ). For each dataset gene pair, significance is calculated by comparing positive vs negative cells and depicted in the positive cell column. Four human LUAD datasets are shown [LungM 5 ; LungK ; LungB ; LungD ] along with plastic cell states [OF/HRC , , lowerSpike , Plasticity ] in other cancers [CRC ; SCC ; PCa ; PDAC ; HNC_C , HNC_K , OC ]. t-test. d, Immunofluorescence of human LUAD stained for (top) uPAR (green) and integrin α2 (red) or (bottom) pan-cytokeratin (white). Arrows point to uPAR and integrin α2 double positive cells. Scale bar: 25 μm. e, Heatmaps demonstrating mean gene signature score in either Slc4a11 or Plaur negative and positive cells scaled using a z-score generated per program to compare gene signatures across different injury models in mouse single cell datasets ( Supplementary Table 5 ). Heatmaps of signature scores represented as z-scores of the indicated regenerative programs in Lung (DATP: damage associated transient progenitor ; ADI: KRT8 + alveolar differentiation intermediate ; PATS: pre-alveolar type-1 transitional cell state ), Pancreas (scBasal cell state ), Intestine (revSC: revival stem cell ; SSC2: singly profiled stem cell cluster 2 ) and Skin (Wound ). For each dataset gene pair, significance is calculated by comparing positive vs negative cells and depicted in the positive cell column. t-test. f, Representative multiplex FISH staining of Slc4a11 (red) and Sftpc (green) in normal lungs vs. 7 days following <t>hyperoxia-induced</t> lung injury. Scale bar: 10 µm.
    122 Hyperoxia Chamber, supplied by BioSpherix, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Image Search Results


    a, Heatmap of Pearson correlations calculated between the HPCS and recurrent pan-cancer cell states (AC: astrocyte-like cell state, OPC: oligodendrocyte progenitor cell-like, NPC: neural progenitor cell-like) , divided by cancer type (BC: breast cancer, CRC: colorectal cancer, HNC: head and neck cancer, LUAD: lung adenocarcinoma, OC: ovarian cancer, PCa: prostate adenocarcinoma, PDAC: pancreatic ductal adenocarcinoma, SCC: squamous cell carcinoma of the skin, ALL: acute lymphoblastic leukemia, MM: multiple myeloma). Arrow indicates the Stress -associated cell state from ref. . A full list of studies is listed in Supplementary Table 5 . b, Pearson correlation between the HPCS signature score ( x -axis) and plastic cell states ( y -axis) from either colorectal cancer (OF/HRC: oncofetal/core high relapse , ) ( top ), and pancreatic ductal adenocarcinoma (scBasal ) ( middle ), or castration-resistant prostate cancer adenocarcinoma (Plasticity ) ( bottom ). Two-tailed p value calculated from the exact distribution of Pearson correlation coefficient. c , Heatmaps demonstrating mean gene signature score in either SLC4A11 or PLAUR negative and positive cells scaled using a z-score generated per program to compare gene signatures across different cancer types in human scRNA-seq datasets ( Supplementary Table 5 ). For each dataset gene pair, significance is calculated by comparing positive vs negative cells and depicted in the positive cell column. Four human LUAD datasets are shown [LungM 5 ; LungK ; LungB ; LungD ] along with plastic cell states [OF/HRC , , lowerSpike , Plasticity ] in other cancers [CRC ; SCC ; PCa ; PDAC ; HNC_C , HNC_K , OC ]. t-test. d, Immunofluorescence of human LUAD stained for (top) uPAR (green) and integrin α2 (red) or (bottom) pan-cytokeratin (white). Arrows point to uPAR and integrin α2 double positive cells. Scale bar: 25 μm. e, Heatmaps demonstrating mean gene signature score in either Slc4a11 or Plaur negative and positive cells scaled using a z-score generated per program to compare gene signatures across different injury models in mouse single cell datasets ( Supplementary Table 5 ). Heatmaps of signature scores represented as z-scores of the indicated regenerative programs in Lung (DATP: damage associated transient progenitor ; ADI: KRT8 + alveolar differentiation intermediate ; PATS: pre-alveolar type-1 transitional cell state ), Pancreas (scBasal cell state ), Intestine (revSC: revival stem cell ; SSC2: singly profiled stem cell cluster 2 ) and Skin (Wound ). For each dataset gene pair, significance is calculated by comparing positive vs negative cells and depicted in the positive cell column. t-test. f, Representative multiplex FISH staining of Slc4a11 (red) and Sftpc (green) in normal lungs vs. 7 days following hyperoxia-induced lung injury. Scale bar: 10 µm.

    Journal: bioRxiv

    Article Title: Functional interrogation uncovers a critical role for a high-plasticity cell state in lung adenocarcinoma

    doi: 10.1101/2025.10.03.680232

    Figure Lengend Snippet: a, Heatmap of Pearson correlations calculated between the HPCS and recurrent pan-cancer cell states (AC: astrocyte-like cell state, OPC: oligodendrocyte progenitor cell-like, NPC: neural progenitor cell-like) , divided by cancer type (BC: breast cancer, CRC: colorectal cancer, HNC: head and neck cancer, LUAD: lung adenocarcinoma, OC: ovarian cancer, PCa: prostate adenocarcinoma, PDAC: pancreatic ductal adenocarcinoma, SCC: squamous cell carcinoma of the skin, ALL: acute lymphoblastic leukemia, MM: multiple myeloma). Arrow indicates the Stress -associated cell state from ref. . A full list of studies is listed in Supplementary Table 5 . b, Pearson correlation between the HPCS signature score ( x -axis) and plastic cell states ( y -axis) from either colorectal cancer (OF/HRC: oncofetal/core high relapse , ) ( top ), and pancreatic ductal adenocarcinoma (scBasal ) ( middle ), or castration-resistant prostate cancer adenocarcinoma (Plasticity ) ( bottom ). Two-tailed p value calculated from the exact distribution of Pearson correlation coefficient. c , Heatmaps demonstrating mean gene signature score in either SLC4A11 or PLAUR negative and positive cells scaled using a z-score generated per program to compare gene signatures across different cancer types in human scRNA-seq datasets ( Supplementary Table 5 ). For each dataset gene pair, significance is calculated by comparing positive vs negative cells and depicted in the positive cell column. Four human LUAD datasets are shown [LungM 5 ; LungK ; LungB ; LungD ] along with plastic cell states [OF/HRC , , lowerSpike , Plasticity ] in other cancers [CRC ; SCC ; PCa ; PDAC ; HNC_C , HNC_K , OC ]. t-test. d, Immunofluorescence of human LUAD stained for (top) uPAR (green) and integrin α2 (red) or (bottom) pan-cytokeratin (white). Arrows point to uPAR and integrin α2 double positive cells. Scale bar: 25 μm. e, Heatmaps demonstrating mean gene signature score in either Slc4a11 or Plaur negative and positive cells scaled using a z-score generated per program to compare gene signatures across different injury models in mouse single cell datasets ( Supplementary Table 5 ). Heatmaps of signature scores represented as z-scores of the indicated regenerative programs in Lung (DATP: damage associated transient progenitor ; ADI: KRT8 + alveolar differentiation intermediate ; PATS: pre-alveolar type-1 transitional cell state ), Pancreas (scBasal cell state ), Intestine (revSC: revival stem cell ; SSC2: singly profiled stem cell cluster 2 ) and Skin (Wound ). For each dataset gene pair, significance is calculated by comparing positive vs negative cells and depicted in the positive cell column. t-test. f, Representative multiplex FISH staining of Slc4a11 (red) and Sftpc (green) in normal lungs vs. 7 days following hyperoxia-induced lung injury. Scale bar: 10 µm.

    Article Snippet: Alveolar injury was induced in young C57BL/6 mice by a 32 hour exposure to >85% O 2 in a hyperoxia chamber (BioSpherix), with FiO 2 concentration maintained at a constant flow of ∼3 L O 2 /minute and monitored by an in-line oxygen analyzer.

    Techniques: Two Tailed Test, Generated, Immunofluorescence, Staining, Multiplex Assay