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Fold change and receiver operating characteristic (ROC) curve of plasma microRNAs (miRNAs) of post‐menopausal osteoporotic women with different skeletal muscle mass. Differences of circulating level and ROC curve analysis of up‐regulated miRNAs (A) and down‐regulated miRNAs (B) in osteoporotic women within the first tertile (relative‐low appendicular skeletal muscle mass index [ASMMI]) compared with osteoporotic women within the third tertile (relative‐high ASMMI). Circulating levels of miRNAs are expressed as min to max and compared using a Mann–Whitney t ‐test. The relative area under the curve (AUC) and P ‐value are shown for each ROC curve analysis. The statistics were considered significant when P < 0.05 (* P < 0.05, ** P < 0.01 and *** P < 0.001). Statistical analysis was performed with Prism® Version 6.01 (GraphPad Software).
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Fold change and receiver operating characteristic (ROC) curve of plasma microRNAs (miRNAs) of post‐menopausal osteoporotic women with different skeletal muscle mass. Differences of circulating level and ROC curve analysis of up‐regulated miRNAs (A) and down‐regulated miRNAs (B) in osteoporotic women within the first tertile (relative‐low appendicular skeletal muscle mass index [ASMMI]) compared with osteoporotic women within the third tertile (relative‐high ASMMI). Circulating levels of miRNAs are expressed as min to max and compared using a Mann–Whitney t ‐test. The relative area under the curve (AUC) and P ‐value are shown for each ROC curve analysis. The statistics were considered significant when P < 0.05 (* P < 0.05, ** P < 0.01 and *** P < 0.001). Statistical analysis was performed with Prism® Version 6.01 (GraphPad Software).
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Fold change and receiver operating characteristic (ROC) curve of plasma microRNAs (miRNAs) of post‐menopausal osteoporotic women with different skeletal muscle mass. Differences of circulating level and ROC curve analysis of up‐regulated miRNAs (A) and down‐regulated miRNAs (B) in osteoporotic women within the first tertile (relative‐low appendicular skeletal muscle mass index [ASMMI]) compared with osteoporotic women within the third tertile (relative‐high ASMMI). Circulating levels of miRNAs are expressed as min to max and compared using a Mann–Whitney t ‐test. The relative area under the curve (AUC) and P ‐value are shown for each ROC curve analysis. The statistics were considered significant when P < 0.05 (* P < 0.05, ** P < 0.01 and *** P < 0.001). Statistical analysis was performed with Prism® Version 6.01 (GraphPad Software).
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Fold change and receiver operating characteristic (ROC) curve of plasma microRNAs (miRNAs) of post‐menopausal osteoporotic women with different skeletal muscle mass. Differences of circulating level and ROC curve analysis of up‐regulated miRNAs (A) and down‐regulated miRNAs (B) in osteoporotic women within the first tertile (relative‐low appendicular skeletal muscle mass index [ASMMI]) compared with osteoporotic women within the third tertile (relative‐high ASMMI). Circulating levels of miRNAs are expressed as min to max and compared using a Mann–Whitney t ‐test. The relative area under the curve (AUC) and P ‐value are shown for each ROC curve analysis. The statistics were considered significant when P < 0.05 (* P < 0.05, ** P < 0.01 and *** P < 0.001). Statistical analysis was performed with Prism® Version 6.01 (GraphPad Software).
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Fold change and receiver operating characteristic (ROC) curve of plasma microRNAs (miRNAs) of post‐menopausal osteoporotic women with different skeletal muscle mass. Differences of circulating level and ROC curve analysis of up‐regulated miRNAs (A) and down‐regulated miRNAs (B) in osteoporotic women within the first tertile (relative‐low appendicular skeletal muscle mass index [ASMMI]) compared with osteoporotic women within the third tertile (relative‐high ASMMI). Circulating levels of miRNAs are expressed as min to max and compared using a Mann–Whitney t ‐test. The relative area under the curve (AUC) and P ‐value are shown for each ROC curve analysis. The statistics were considered significant when P < 0.05 (* P < 0.05, ** P < 0.01 and *** P < 0.001). Statistical analysis was performed with Prism® Version 6.01 (GraphPad Software).

Journal: Journal of Cachexia, Sarcopenia and Muscle

Article Title: Plasma microRNA signature associated with skeletal muscle wasting in post‐menopausal osteoporotic women

doi: 10.1002/jcsm.13421

Figure Lengend Snippet: Fold change and receiver operating characteristic (ROC) curve of plasma microRNAs (miRNAs) of post‐menopausal osteoporotic women with different skeletal muscle mass. Differences of circulating level and ROC curve analysis of up‐regulated miRNAs (A) and down‐regulated miRNAs (B) in osteoporotic women within the first tertile (relative‐low appendicular skeletal muscle mass index [ASMMI]) compared with osteoporotic women within the third tertile (relative‐high ASMMI). Circulating levels of miRNAs are expressed as min to max and compared using a Mann–Whitney t ‐test. The relative area under the curve (AUC) and P ‐value are shown for each ROC curve analysis. The statistics were considered significant when P < 0.05 (* P < 0.05, ** P < 0.01 and *** P < 0.001). Statistical analysis was performed with Prism® Version 6.01 (GraphPad Software).

Article Snippet: Data analysis was performed using GenEx software Version 6 (Exiqon), considering all post‐analytical variables.

Techniques: MANN-WHITNEY, Software

Adipo‐myokines plasma profile in post‐menopausal osteoporotic women with different skeletal muscle mass. Differences in circulating levels of adipo‐myokines in osteoporotic women of first tertile (relative‐low appendicular skeletal muscle mass index [ASMMI]) compared with osteoporotic women of third tertile (relative‐high ASMMI). All data are expressed as min to max and compared through a parametric unpaired t ‐test. Statistical analysis was performed with Prism® Version 6.01 (GraphPad Software). The differences were considered significant when P < 0.05 (* P < 0.05, ** P < 0.01 and *** P < 0.001). IL‐8, interleukin‐8; PAI‐1, plasminogen activator inhibitor‐1.

Journal: Journal of Cachexia, Sarcopenia and Muscle

Article Title: Plasma microRNA signature associated with skeletal muscle wasting in post‐menopausal osteoporotic women

doi: 10.1002/jcsm.13421

Figure Lengend Snippet: Adipo‐myokines plasma profile in post‐menopausal osteoporotic women with different skeletal muscle mass. Differences in circulating levels of adipo‐myokines in osteoporotic women of first tertile (relative‐low appendicular skeletal muscle mass index [ASMMI]) compared with osteoporotic women of third tertile (relative‐high ASMMI). All data are expressed as min to max and compared through a parametric unpaired t ‐test. Statistical analysis was performed with Prism® Version 6.01 (GraphPad Software). The differences were considered significant when P < 0.05 (* P < 0.05, ** P < 0.01 and *** P < 0.001). IL‐8, interleukin‐8; PAI‐1, plasminogen activator inhibitor‐1.

Article Snippet: Data analysis was performed using GenEx software Version 6 (Exiqon), considering all post‐analytical variables.

Techniques: Software