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Intific Inc custom-built software
After an initial screening day (Day 1), Days 2 and 3 followed the same overall procedure with participants fully instrumented. Participants first trained on wayfinding tasks in the VR environment. Following encoding, a declarative item memory pre-test was administered followed by the first awake replay (AR) session. During a ∼90 min nap, auditory cues were presented to the CL-TMR participants whereas control participants napped without cue delivery. After the nap, participants took a declarative item-memory post-test, underwent a second AR session, and took a <t>navigation</t> test on a subset of routes encountered during encoding. Participants returned the following day for Day 3 and underwent the same procedure except some elements were changed in the VR training task and test. On Day 4, participants were not fully instrumented while taking declarative memory tests and a final navigation test.
Custom Built Software, supplied by Intific Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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1) Product Images from "Closed-Loop Targeted Memory Reactivation during Sleep Improves Spatial Navigation"

Article Title: Closed-Loop Targeted Memory Reactivation during Sleep Improves Spatial Navigation

Journal: Frontiers in Human Neuroscience

doi: 10.3389/fnhum.2018.00028

After an initial screening day (Day 1), Days 2 and 3 followed the same overall procedure with participants fully instrumented. Participants first trained on wayfinding tasks in the VR environment. Following encoding, a declarative item memory pre-test was administered followed by the first awake replay (AR) session. During a ∼90 min nap, auditory cues were presented to the CL-TMR participants whereas control participants napped without cue delivery. After the nap, participants took a declarative item-memory post-test, underwent a second AR session, and took a navigation test on a subset of routes encountered during encoding. Participants returned the following day for Day 3 and underwent the same procedure except some elements were changed in the VR training task and test. On Day 4, participants were not fully instrumented while taking declarative memory tests and a final navigation test.
Figure Legend Snippet: After an initial screening day (Day 1), Days 2 and 3 followed the same overall procedure with participants fully instrumented. Participants first trained on wayfinding tasks in the VR environment. Following encoding, a declarative item memory pre-test was administered followed by the first awake replay (AR) session. During a ∼90 min nap, auditory cues were presented to the CL-TMR participants whereas control participants napped without cue delivery. After the nap, participants took a declarative item-memory post-test, underwent a second AR session, and took a navigation test on a subset of routes encountered during encoding. Participants returned the following day for Day 3 and underwent the same procedure except some elements were changed in the VR training task and test. On Day 4, participants were not fully instrumented while taking declarative memory tests and a final navigation test.

Techniques Used: Control

Participants who received CL-TMR show reduced  navigation  time.
Figure Legend Snippet: Participants who received CL-TMR show reduced navigation time.

Techniques Used: Control

Navigation learning increases spindle energy in controls. Topoplots show the mean DUPT-locked spindle energy ( z -scored) for each day and the change between Days 1 and 2 (Day 2 Δ) and Days 1 and 3 (Day 3 Δ). Slow spindles (9–12 Hz) show a more frontal topography across days. Increases in Day 2 are small and localized to frontal and centroparietal electrodes. Day 3 differences are larger and more widespread covering almost the entire head. Differences in fast spindle topography are mostly localized to frontal electrodes and are stronger on Day 3. Color bars indicate units of standard deviation in spindle amplitude.
Figure Legend Snippet: Navigation learning increases spindle energy in controls. Topoplots show the mean DUPT-locked spindle energy ( z -scored) for each day and the change between Days 1 and 2 (Day 2 Δ) and Days 1 and 3 (Day 3 Δ). Slow spindles (9–12 Hz) show a more frontal topography across days. Increases in Day 2 are small and localized to frontal and centroparietal electrodes. Day 3 differences are larger and more widespread covering almost the entire head. Differences in fast spindle topography are mostly localized to frontal electrodes and are stronger on Day 3. Color bars indicate units of standard deviation in spindle amplitude.

Techniques Used: Standard Deviation

Related Articles

Software:

Article Title: Closed-Loop Targeted Memory Reactivation during Sleep Improves Spatial Navigation
Article Snippet: The virtual reality (VR) navigation task performed by participants was designed by the authors and implemented into custom-built software by Intific, Inc. (Austin, TX, United States) using the Unreal Engine.

Control:

Article Title: Closed-Loop Targeted Memory Reactivation during Sleep Improves Spatial Navigation
Article Snippet: The virtual reality (VR) navigation task performed by participants was designed by the authors and implemented into custom-built software by Intific, Inc. (Austin, TX, United States) using the Unreal Engine.

Standard Deviation:

Article Title: Closed-Loop Targeted Memory Reactivation during Sleep Improves Spatial Navigation
Article Snippet: The virtual reality (VR) navigation task performed by participants was designed by the authors and implemented into custom-built software by Intific, Inc. (Austin, TX, United States) using the Unreal Engine.



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