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api 1 (Tocris)

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Tocris api 1
Api 1, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 14 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/api/API-1/pmc06697950-74-42-43
Average 94 stars, based on 14 article reviews

api 1 - by Bioz Stars, 2026-10

94/100 stars

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Article Title: Signalling pathways involved in p47 phox -dependent reactive oxygen species in platelets of endotoxemic rats.
Article Snippet: A cc ep te d A rt ic le. clinical outcome.. Overproduction of reactive-oxygen species (ROS) by different cell types contributes to sepsis.

Article Title: Mechanisms of carboplatin- and paclitaxel-dependent induction of premature senescence and pro-cancerogenic conversion of normal peritoneal mesothelium and fibroblasts.
Article Snippet: Carboplatin (CPT) and paclitaxel (PCT) are the optimal non-surgical treatment of epithelial ovarian cancer (EOC).. Although their growth-restricting influence on EOC cells is well known, their impact on normal peritoneal cells, including mesothelium (PMCs) and fibroblasts (PFBs), is poorly understood.. Here, we investigated whether, and if so, by what mechanism, CPT and PCT induce senescence of omental PMCs and PFBs.

Article Title: The peroxidase PRDX1 inhibits the activated phenotype in mammary fibroblasts through regulating c-Jun N-terminal kinases
Article Snippet: Before the individual experiments, cells were starved for 48 h in 0.25% FBS DMEM and pretreated for 1–2 h with 25 μM JNK inhibitor, SP600125 (Tocris Bioscience), 2 μM JNK-IN-8 (a kind gift from Dr. Nathanial Grey, DFCI, Boston) or 10 μM API-1 (Tocris Bioscience).

Blocking Assay:

Article Title: Senescence-related deterioration of intercellular junctions in the peritoneal mesothelium promotes the transmesothelial invasion of ovarian cancer cells
Article Snippet: Unless otherwise stated, all chemicals and plastics were from Merck (Darmstadt, Germany). .. Signaling pathway inhibitors: MG132 (NF-κB), API-1 (AKT), SP600125 (JNK), and 3-Aminobenzamide (AP-1) were from Tocris Bioscience (Ellisville, MO); SB202190 (p38 MAPK) was from Cell Signaling Technology (Danvers, MA); mithramycin A (SP-1) was from Cayman Chemical (Ann Arbor, MI); and peptides blocking TBX2 and Nkx2-5 were from MyBioSource (San Diego, CA). .. Antibodies neutralizing GRO-1, HGF, and TGF-β1, as well as the control IgY (AB-101-C) were from R&D Systems (Abingdon, UK).

Control:

Article Title: The Role of Akt/Rab5A Signalling in Regulating Cell Migration of MDA-MB-231 Breast Cancer Cell Line
Article Snippet: To test cells for mycoplasma, an EZ-PCR Mycoplasma Based detection (Geneflow, K1-0210, UK) was utilized on a routine basis. .. Dynasore (20 mM) (Selleckchem, S8047), as well as Pitstop 2 (25 mM) (Abcam, ab120687), were employed to suppress dynamin, clathrin-mediated endocytosis, API-1 (5 μM) to inhibit Akt (TOCRIS; Cat. No. 3897) and 0.1% of dimethyl sulfoxide (DMSO) was used as a control. ..