ticlopidine Search Results


ticlopidine  (MedChemExpress)
90
MedChemExpress ticlopidine
( a-i ) Experimental design ( a ), weight ( b ), representative photograph ( c ), Echo-MRI-based fat/lean mass distribution analysis on Week 20 ( d ), representative microphotographs ( e ) with adipocyte edges detection and area quantification of hematoxylin and eosin-stained perigonadal white adipose tissue ( f , n = 3), insulin ( g ) and glucose ( h ) tolerance tests, cumulative food intake on Week 20 ( i ) in HFD-fed male mice nasally administered once a day with 1 mg/kg clopidogrel, 0.14 mg/kg prasugrel, 3.57 mg/kg <t>ticlopidine</t> or the same volume of the vehicle and chow diet-fed male mice receiving vehicle (unless otherwise stated, n = 5, 5, 7, 5, and 5, respectively, except n = 6 for the HFD-Ticlopidine group in tolerance tests depicted in panels g and h ). Error bars represent SEM. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 as analyzed by two-way ANOVA with post-hoc Holm-Šídák’s test of HFD-Ticlopidine and HFD-Prasugrel vs. HFD-Vehicle groups ( b ) or between all groups ( g,h,i ), and one-way ANOVA followed by post-hoc Holm-Šídák’s test ( d,f ). Significant differences vs. respective groups are outlined with color. Scale bar: 100 µm.
Ticlopidine, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ticlopidine/product/MedChemExpress
Average 90 stars, based on 1 article reviews
ticlopidine - by Bioz Stars, 2026-04
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ticlopidine hydrochloride  (Toronto Research Chemicals)
90
Toronto Research Chemicals ticlopidine hydrochloride
( a-i ) Experimental design ( a ), weight ( b ), representative photograph ( c ), Echo-MRI-based fat/lean mass distribution analysis on Week 20 ( d ), representative microphotographs ( e ) with adipocyte edges detection and area quantification of hematoxylin and eosin-stained perigonadal white adipose tissue ( f , n = 3), insulin ( g ) and glucose ( h ) tolerance tests, cumulative food intake on Week 20 ( i ) in HFD-fed male mice nasally administered once a day with 1 mg/kg clopidogrel, 0.14 mg/kg prasugrel, 3.57 mg/kg <t>ticlopidine</t> or the same volume of the vehicle and chow diet-fed male mice receiving vehicle (unless otherwise stated, n = 5, 5, 7, 5, and 5, respectively, except n = 6 for the HFD-Ticlopidine group in tolerance tests depicted in panels g and h ). Error bars represent SEM. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 as analyzed by two-way ANOVA with post-hoc Holm-Šídák’s test of HFD-Ticlopidine and HFD-Prasugrel vs. HFD-Vehicle groups ( b ) or between all groups ( g,h,i ), and one-way ANOVA followed by post-hoc Holm-Šídák’s test ( d,f ). Significant differences vs. respective groups are outlined with color. Scale bar: 100 µm.
Ticlopidine Hydrochloride, supplied by Toronto Research Chemicals, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ticlopidine hydrochloride/product/Toronto Research Chemicals
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ticlopidine  (IPHASE Biosciences Inc)
90
IPHASE Biosciences Inc ticlopidine
( a-i ) Experimental design ( a ), weight ( b ), representative photograph ( c ), Echo-MRI-based fat/lean mass distribution analysis on Week 20 ( d ), representative microphotographs ( e ) with adipocyte edges detection and area quantification of hematoxylin and eosin-stained perigonadal white adipose tissue ( f , n = 3), insulin ( g ) and glucose ( h ) tolerance tests, cumulative food intake on Week 20 ( i ) in HFD-fed male mice nasally administered once a day with 1 mg/kg clopidogrel, 0.14 mg/kg prasugrel, 3.57 mg/kg <t>ticlopidine</t> or the same volume of the vehicle and chow diet-fed male mice receiving vehicle (unless otherwise stated, n = 5, 5, 7, 5, and 5, respectively, except n = 6 for the HFD-Ticlopidine group in tolerance tests depicted in panels g and h ). Error bars represent SEM. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 as analyzed by two-way ANOVA with post-hoc Holm-Šídák’s test of HFD-Ticlopidine and HFD-Prasugrel vs. HFD-Vehicle groups ( b ) or between all groups ( g,h,i ), and one-way ANOVA followed by post-hoc Holm-Šídák’s test ( d,f ). Significant differences vs. respective groups are outlined with color. Scale bar: 100 µm.
Ticlopidine, supplied by IPHASE Biosciences Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ticlopidine/product/IPHASE Biosciences Inc
Average 90 stars, based on 1 article reviews
ticlopidine - by Bioz Stars, 2026-04
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ticlopidine  (Bruker Corporation)
90
Bruker Corporation ticlopidine
( a-i ) Experimental design ( a ), weight ( b ), representative photograph ( c ), Echo-MRI-based fat/lean mass distribution analysis on Week 20 ( d ), representative microphotographs ( e ) with adipocyte edges detection and area quantification of hematoxylin and eosin-stained perigonadal white adipose tissue ( f , n = 3), insulin ( g ) and glucose ( h ) tolerance tests, cumulative food intake on Week 20 ( i ) in HFD-fed male mice nasally administered once a day with 1 mg/kg clopidogrel, 0.14 mg/kg prasugrel, 3.57 mg/kg <t>ticlopidine</t> or the same volume of the vehicle and chow diet-fed male mice receiving vehicle (unless otherwise stated, n = 5, 5, 7, 5, and 5, respectively, except n = 6 for the HFD-Ticlopidine group in tolerance tests depicted in panels g and h ). Error bars represent SEM. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 as analyzed by two-way ANOVA with post-hoc Holm-Šídák’s test of HFD-Ticlopidine and HFD-Prasugrel vs. HFD-Vehicle groups ( b ) or between all groups ( g,h,i ), and one-way ANOVA followed by post-hoc Holm-Šídák’s test ( d,f ). Significant differences vs. respective groups are outlined with color. Scale bar: 100 µm.
Ticlopidine, supplied by Bruker Corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ticlopidine/product/Bruker Corporation
Average 90 stars, based on 1 article reviews
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ticlopidin-neuraxpharm  (Neuraxpharm Arzneimittel)
90
Neuraxpharm Arzneimittel ticlopidin-neuraxpharm
( a-i ) Experimental design ( a ), weight ( b ), representative photograph ( c ), Echo-MRI-based fat/lean mass distribution analysis on Week 20 ( d ), representative microphotographs ( e ) with adipocyte edges detection and area quantification of hematoxylin and eosin-stained perigonadal white adipose tissue ( f , n = 3), insulin ( g ) and glucose ( h ) tolerance tests, cumulative food intake on Week 20 ( i ) in HFD-fed male mice nasally administered once a day with 1 mg/kg clopidogrel, 0.14 mg/kg prasugrel, 3.57 mg/kg <t>ticlopidine</t> or the same volume of the vehicle and chow diet-fed male mice receiving vehicle (unless otherwise stated, n = 5, 5, 7, 5, and 5, respectively, except n = 6 for the HFD-Ticlopidine group in tolerance tests depicted in panels g and h ). Error bars represent SEM. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 as analyzed by two-way ANOVA with post-hoc Holm-Šídák’s test of HFD-Ticlopidine and HFD-Prasugrel vs. HFD-Vehicle groups ( b ) or between all groups ( g,h,i ), and one-way ANOVA followed by post-hoc Holm-Šídák’s test ( d,f ). Significant differences vs. respective groups are outlined with color. Scale bar: 100 µm.
Ticlopidin Neuraxpharm, supplied by Neuraxpharm Arzneimittel, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ticlopidine (t303965)  (Shanghai Aladdin Bio-Chem)
90
Shanghai Aladdin Bio-Chem ticlopidine (t303965)
A Concentrations of phenacetin after coincubation with 25 μM furafylline and 5 mg/L phenacetin. B Concentrations of dapsone after coincubation with 25 μM ketoconazole and 5 mg/L dapsone. C Concentrations of dextromethorphan after coincubation with 25 μM quinidine and 5 mg/L dextromethorphan. D Concentrations of omeprazole after coincubation with 25 μM <t>ticlopidine</t> and 5 mg/L omeprazole. E Concentrations of chlorzoxazone after coincubation with 25 μM chlormethiazole and 5 mg/L chlorzoxazone. ** P < 0.01.
Ticlopidine (T303965), supplied by Shanghai Aladdin Bio-Chem, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ticlopidine (t303965)/product/Shanghai Aladdin Bio-Chem
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ticlopidine  (Sanofi)
90
Sanofi ticlopidine
A Concentrations of phenacetin after coincubation with 25 μM furafylline and 5 mg/L phenacetin. B Concentrations of dapsone after coincubation with 25 μM ketoconazole and 5 mg/L dapsone. C Concentrations of dextromethorphan after coincubation with 25 μM quinidine and 5 mg/L dextromethorphan. D Concentrations of omeprazole after coincubation with 25 μM <t>ticlopidine</t> and 5 mg/L omeprazole. E Concentrations of chlorzoxazone after coincubation with 25 μM chlormethiazole and 5 mg/L chlorzoxazone. ** P < 0.01.
Ticlopidine, supplied by Sanofi, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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sulconazole, quercetin and ticlopidine  (Krackeler Scientific)
90
Krackeler Scientific sulconazole, quercetin and ticlopidine
Inhibitor potencies on CYP2C24 and related CYP2C isoforms.
Sulconazole, Quercetin And Ticlopidine, supplied by Krackeler Scientific, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/sulconazole, quercetin and ticlopidine/product/Krackeler Scientific
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ticlopidine  (Blackwell Science Ltd)
90
Blackwell Science Ltd ticlopidine
Inhibitor potencies on CYP2C24 and related CYP2C isoforms.
Ticlopidine, supplied by Blackwell Science Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ticlopidine  (Fluka Chemical)
90
Fluka Chemical ticlopidine
Inhibitor potencies on CYP2C24 and related CYP2C isoforms.
Ticlopidine, supplied by Fluka Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ticlopidine  (Taihe Biotechnology Co Ltd)
90
Taihe Biotechnology Co Ltd ticlopidine
Inhibitor potencies on CYP2C24 and related CYP2C isoforms.
Ticlopidine, supplied by Taihe Biotechnology Co Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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clopidogrel incorporating the napadisilate salt  (Hanmi Pharmaceutical)
90
Hanmi Pharmaceutical clopidogrel incorporating the napadisilate salt
Current stroke drugs in the market.
Clopidogrel Incorporating The Napadisilate Salt, supplied by Hanmi Pharmaceutical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


( a-i ) Experimental design ( a ), weight ( b ), representative photograph ( c ), Echo-MRI-based fat/lean mass distribution analysis on Week 20 ( d ), representative microphotographs ( e ) with adipocyte edges detection and area quantification of hematoxylin and eosin-stained perigonadal white adipose tissue ( f , n = 3), insulin ( g ) and glucose ( h ) tolerance tests, cumulative food intake on Week 20 ( i ) in HFD-fed male mice nasally administered once a day with 1 mg/kg clopidogrel, 0.14 mg/kg prasugrel, 3.57 mg/kg ticlopidine or the same volume of the vehicle and chow diet-fed male mice receiving vehicle (unless otherwise stated, n = 5, 5, 7, 5, and 5, respectively, except n = 6 for the HFD-Ticlopidine group in tolerance tests depicted in panels g and h ). Error bars represent SEM. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 as analyzed by two-way ANOVA with post-hoc Holm-Šídák’s test of HFD-Ticlopidine and HFD-Prasugrel vs. HFD-Vehicle groups ( b ) or between all groups ( g,h,i ), and one-way ANOVA followed by post-hoc Holm-Šídák’s test ( d,f ). Significant differences vs. respective groups are outlined with color. Scale bar: 100 µm.

Journal: bioRxiv

Article Title: Enhanced purinergic signaling in the paraventricular hypothalamus induces hyperphagic obesity and insulin resistance

doi: 10.1101/2024.07.02.601503

Figure Lengend Snippet: ( a-i ) Experimental design ( a ), weight ( b ), representative photograph ( c ), Echo-MRI-based fat/lean mass distribution analysis on Week 20 ( d ), representative microphotographs ( e ) with adipocyte edges detection and area quantification of hematoxylin and eosin-stained perigonadal white adipose tissue ( f , n = 3), insulin ( g ) and glucose ( h ) tolerance tests, cumulative food intake on Week 20 ( i ) in HFD-fed male mice nasally administered once a day with 1 mg/kg clopidogrel, 0.14 mg/kg prasugrel, 3.57 mg/kg ticlopidine or the same volume of the vehicle and chow diet-fed male mice receiving vehicle (unless otherwise stated, n = 5, 5, 7, 5, and 5, respectively, except n = 6 for the HFD-Ticlopidine group in tolerance tests depicted in panels g and h ). Error bars represent SEM. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 as analyzed by two-way ANOVA with post-hoc Holm-Šídák’s test of HFD-Ticlopidine and HFD-Prasugrel vs. HFD-Vehicle groups ( b ) or between all groups ( g,h,i ), and one-way ANOVA followed by post-hoc Holm-Šídák’s test ( d,f ). Significant differences vs. respective groups are outlined with color. Scale bar: 100 µm.

Article Snippet: For peroral administration with drinking water and/or nasal delivery, ticlopidine, clopidogrel, prasugrel hydrochloride, ticagrelor (all from APExBIO; B2164, A5183, B1283, B2166, respectively) and cangrelor tetrasodium (MedChemExpress, 163706-36-3) were used at concentrations indicated in the figures.

Techniques: Staining

A Concentrations of phenacetin after coincubation with 25 μM furafylline and 5 mg/L phenacetin. B Concentrations of dapsone after coincubation with 25 μM ketoconazole and 5 mg/L dapsone. C Concentrations of dextromethorphan after coincubation with 25 μM quinidine and 5 mg/L dextromethorphan. D Concentrations of omeprazole after coincubation with 25 μM ticlopidine and 5 mg/L omeprazole. E Concentrations of chlorzoxazone after coincubation with 25 μM chlormethiazole and 5 mg/L chlorzoxazone. ** P < 0.01.

Journal: NPJ Science of Food

Article Title: Sex differences in CYP450-based sodium dehydroacetate metabolism and its metabolites in rats

doi: 10.1038/s41538-024-00361-z

Figure Lengend Snippet: A Concentrations of phenacetin after coincubation with 25 μM furafylline and 5 mg/L phenacetin. B Concentrations of dapsone after coincubation with 25 μM ketoconazole and 5 mg/L dapsone. C Concentrations of dextromethorphan after coincubation with 25 μM quinidine and 5 mg/L dextromethorphan. D Concentrations of omeprazole after coincubation with 25 μM ticlopidine and 5 mg/L omeprazole. E Concentrations of chlorzoxazone after coincubation with 25 μM chlormethiazole and 5 mg/L chlorzoxazone. ** P < 0.01.

Article Snippet: We procured DHA-Na (D806413) and ketoconazole (C12650322) from Shanghai Macklin Bio-Chemical Technology Co., LTD. Quinidine (12004158), dapsone (D105858), phenacetin (P109420), omeprazole (C1920101), ticlopidine (T303965), and dextromethorphan (B300455) were purchased from Shanghai Aladdin Corporation.

Techniques:

A – E Concentrations of DHA-Na after coincubation with DHA-Na and 5–50 μM furafylline ( A ), ketoconazole ( B ), quinidine ( C ), ticlopidine ( D ), or chlormethiazole ( E ). * P < 0.05, ** P < 0.01, compared with control group. # P < 0.05, compared with male group.

Journal: NPJ Science of Food

Article Title: Sex differences in CYP450-based sodium dehydroacetate metabolism and its metabolites in rats

doi: 10.1038/s41538-024-00361-z

Figure Lengend Snippet: A – E Concentrations of DHA-Na after coincubation with DHA-Na and 5–50 μM furafylline ( A ), ketoconazole ( B ), quinidine ( C ), ticlopidine ( D ), or chlormethiazole ( E ). * P < 0.05, ** P < 0.01, compared with control group. # P < 0.05, compared with male group.

Article Snippet: We procured DHA-Na (D806413) and ketoconazole (C12650322) from Shanghai Macklin Bio-Chemical Technology Co., LTD. Quinidine (12004158), dapsone (D105858), phenacetin (P109420), omeprazole (C1920101), ticlopidine (T303965), and dextromethorphan (B300455) were purchased from Shanghai Aladdin Corporation.

Techniques: Control

Sex difference of DHA-Na metabolism in liver microsome after inhibitors treatment

Journal: NPJ Science of Food

Article Title: Sex differences in CYP450-based sodium dehydroacetate metabolism and its metabolites in rats

doi: 10.1038/s41538-024-00361-z

Figure Lengend Snippet: Sex difference of DHA-Na metabolism in liver microsome after inhibitors treatment

Article Snippet: We procured DHA-Na (D806413) and ketoconazole (C12650322) from Shanghai Macklin Bio-Chemical Technology Co., LTD. Quinidine (12004158), dapsone (D105858), phenacetin (P109420), omeprazole (C1920101), ticlopidine (T303965), and dextromethorphan (B300455) were purchased from Shanghai Aladdin Corporation.

Techniques: Concentration Assay, Inhibition, Control

Concentration–time curves for probe substrates in rats after coadministration of ( A ) 5 mg/kg furafylline and 10 mg/kg phenacetin, ( B ) 5 mg/kg dapsone and 25 mg/kg ketoconazole, ( C ) 5 mg/kg dextromethorphan and 10 mg/kg quinidine, ( D ) 10 mg/kg omeprazole and 10 mg/kg ticlopidine co-administration. E 5 mg/kg chlorzoxazone and 25 mg/kg chlormethiazole.

Journal: NPJ Science of Food

Article Title: Sex differences in CYP450-based sodium dehydroacetate metabolism and its metabolites in rats

doi: 10.1038/s41538-024-00361-z

Figure Lengend Snippet: Concentration–time curves for probe substrates in rats after coadministration of ( A ) 5 mg/kg furafylline and 10 mg/kg phenacetin, ( B ) 5 mg/kg dapsone and 25 mg/kg ketoconazole, ( C ) 5 mg/kg dextromethorphan and 10 mg/kg quinidine, ( D ) 10 mg/kg omeprazole and 10 mg/kg ticlopidine co-administration. E 5 mg/kg chlorzoxazone and 25 mg/kg chlormethiazole.

Article Snippet: We procured DHA-Na (D806413) and ketoconazole (C12650322) from Shanghai Macklin Bio-Chemical Technology Co., LTD. Quinidine (12004158), dapsone (D105858), phenacetin (P109420), omeprazole (C1920101), ticlopidine (T303965), and dextromethorphan (B300455) were purchased from Shanghai Aladdin Corporation.

Techniques: Concentration Assay

Concentration–time curves for DHA-Na after coadministration of 200 mg/kg DHA-Na and ( A ) 5 mg/kg furafylline, ( B ) 25 mg/kg ketoconazole, ( C ) 10 mg/kg quinidine, ( D ) 10 mg/kg ticlopidine, and ( E ) 25 mg/kg chlormethiazole.

Journal: NPJ Science of Food

Article Title: Sex differences in CYP450-based sodium dehydroacetate metabolism and its metabolites in rats

doi: 10.1038/s41538-024-00361-z

Figure Lengend Snippet: Concentration–time curves for DHA-Na after coadministration of 200 mg/kg DHA-Na and ( A ) 5 mg/kg furafylline, ( B ) 25 mg/kg ketoconazole, ( C ) 10 mg/kg quinidine, ( D ) 10 mg/kg ticlopidine, and ( E ) 25 mg/kg chlormethiazole.

Article Snippet: We procured DHA-Na (D806413) and ketoconazole (C12650322) from Shanghai Macklin Bio-Chemical Technology Co., LTD. Quinidine (12004158), dapsone (D105858), phenacetin (P109420), omeprazole (C1920101), ticlopidine (T303965), and dextromethorphan (B300455) were purchased from Shanghai Aladdin Corporation.

Techniques: Concentration Assay

Pharmacokinetic parameters of DHA-Na in rats after administration of specific inhibitors

Journal: NPJ Science of Food

Article Title: Sex differences in CYP450-based sodium dehydroacetate metabolism and its metabolites in rats

doi: 10.1038/s41538-024-00361-z

Figure Lengend Snippet: Pharmacokinetic parameters of DHA-Na in rats after administration of specific inhibitors

Article Snippet: We procured DHA-Na (D806413) and ketoconazole (C12650322) from Shanghai Macklin Bio-Chemical Technology Co., LTD. Quinidine (12004158), dapsone (D105858), phenacetin (P109420), omeprazole (C1920101), ticlopidine (T303965), and dextromethorphan (B300455) were purchased from Shanghai Aladdin Corporation.

Techniques: Control

Inhibitor potencies on CYP2C24 and related CYP2C isoforms.

Journal: Acta pharmaceutica Sinica. B

Article Title: Cytochrome P450 2C24: Expression, Tissue Distribution, High-Throughput Assay, and Pharmacological Inhibition

doi: 10.1016/j.apsb.2012.02.003

Figure Lengend Snippet: Inhibitor potencies on CYP2C24 and related CYP2C isoforms.

Article Snippet: Sulconazole, quercetin and ticlopidine were purchased from Krackeler Scientific, Inc. (Albany, NY).

Techniques:

Correlations between inhibitor potencies on CYP2C24 and potencies on human CYP2C isoforms. IC50 values for ten inhibitors on CYP2C24 are plotted (abscissa, log scale) against IC50 values for the same drugs determined CYP2C19, CYP2C9, and CYP2C8 (ordinate, log scale). For each pair of CYPs plotted, values were analyzed by the Spearman rank correlation test. Dashed line indicates the theoretical perfect correlation. Outliers in each correlation are identified by drug abbreviation (sulc, sulconazole; flu, fluconazole; ticl, ticlopidine, sulf, sulfaphenazole). For example, a near-perfect correlation was observed between potencies on CYP2C24 vs. potencies on CYP2C19 except for ticl, which is approximately 30-fold less potent on CYP2C24. All data are from Table 1. Mean values are plotted when the table gave more than one value. For plotting and correlational analyses, values in the table estimated to be larger than 200 µM were arbitrarily designated as 300 µM.

Journal: Acta pharmaceutica Sinica. B

Article Title: Cytochrome P450 2C24: Expression, Tissue Distribution, High-Throughput Assay, and Pharmacological Inhibition

doi: 10.1016/j.apsb.2012.02.003

Figure Lengend Snippet: Correlations between inhibitor potencies on CYP2C24 and potencies on human CYP2C isoforms. IC50 values for ten inhibitors on CYP2C24 are plotted (abscissa, log scale) against IC50 values for the same drugs determined CYP2C19, CYP2C9, and CYP2C8 (ordinate, log scale). For each pair of CYPs plotted, values were analyzed by the Spearman rank correlation test. Dashed line indicates the theoretical perfect correlation. Outliers in each correlation are identified by drug abbreviation (sulc, sulconazole; flu, fluconazole; ticl, ticlopidine, sulf, sulfaphenazole). For example, a near-perfect correlation was observed between potencies on CYP2C24 vs. potencies on CYP2C19 except for ticl, which is approximately 30-fold less potent on CYP2C24. All data are from Table 1. Mean values are plotted when the table gave more than one value. For plotting and correlational analyses, values in the table estimated to be larger than 200 µM were arbitrarily designated as 300 µM.

Article Snippet: Sulconazole, quercetin and ticlopidine were purchased from Krackeler Scientific, Inc. (Albany, NY).

Techniques:

Current stroke drugs in the market.

Journal: Acta Pharmaceutica Sinica. B

Article Title: The fate of medications evaluated for ischemic stroke pharmacotherapy over the period 1995–2015

doi: 10.1016/j.apsb.2016.06.013

Figure Lengend Snippet: Current stroke drugs in the market.

Article Snippet: Hanmi Pharmaceuticals launched a safer, more effective and convenient formulation of clopidogrel incorporating the napadisilate salt in March of 2015.

Techniques: Recombinant, Injection