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DIAGENODE DIAGNOSTICS
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Boehringer Mannheim
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Qiagen
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GoldMag Nanobiotech
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Image Search Results
Journal: Drug Design, Development and Therapy
Article Title: Selection of DNA Aptamers Recognizing EpCAM-Positive Prostate Cancer by Cell-SELEX for in vitro and in vivo MR Imaging
doi: 10.2147/DDDT.S322854
Figure Lengend Snippet: Flow cytometric analysis of binding abilities of aptamer-conjugated GoldMag nanoparticles to HEK293T-EpCAM cells and three types of EpCAM-positive prostate cancer cell lines ( A ). Immunofluorescence staining analysis of aptamer-conjugated GoldMag nanoparticles to three types of EpCAM-positive prostate cancer cell lines ( B ). Mock cells represents HEK293T cells mock-transfected with the empty pCDH-CMV-MCS-EF1-Puro plasmid; ssDNA-GoldMag represents random single strand DNA conjugated with GoldMag nanoparticles as negative control. Scale bars correspond to 50 μm in all images.
Article Snippet: MRI represents magnetic resonance imaging; T2WI represents T2-weighted imaging; ssDNA-GoldMag represents random single strand DNA conjugated with
Techniques: Binding Assay, Immunofluorescence, Staining, Transfection, Plasmid Preparation, Negative Control
Journal: Drug Design, Development and Therapy
Article Title: Selection of DNA Aptamers Recognizing EpCAM-Positive Prostate Cancer by Cell-SELEX for in vitro and in vivo MR Imaging
doi: 10.2147/DDDT.S322854
Figure Lengend Snippet: In vitro MRI of Eppc6-GoldMag targeted EpCAM-positive prostate cancer cells ( A ). Quantitative signal intensity measurement of T2WI ( B ) for the cell sample put in eppendorf tubes depicted in ( A ). Tube 1: PC-3 cells + ssDNA-GoldMag; tube 2: DU145 cells + ssDNA-GoldMag; tube 3: LNCaP cells + ssDNA-GoldMag; tube 4: PC-3 cells + Eppc6-GoldMag; tube 5: DU145 cells + Eppc6-GoldMag; tube 6: LNCaP cells + Eppc6-GoldMag. MRI represents magnetic resonance imaging; T2WI represents T2-weighted imaging; ssDNA-GoldMag represents random single strand DNA conjugated with GoldMag nanoparticles as negative control. **** P < 0.0001.
Article Snippet: MRI represents magnetic resonance imaging; T2WI represents T2-weighted imaging; ssDNA-GoldMag represents random single strand DNA conjugated with
Techniques: In Vitro, Magnetic Resonance Imaging, Imaging, Negative Control
Journal: Drug Design, Development and Therapy
Article Title: Selection of DNA Aptamers Recognizing EpCAM-Positive Prostate Cancer by Cell-SELEX for in vitro and in vivo MR Imaging
doi: 10.2147/DDDT.S322854
Figure Lengend Snippet: In vivo MRI for prostate tumor-bearing nude mice at pre-injection and 1, 6 and 12 h after injection of Eppc6-GoldMag nanoparticles ( A ), which demonstrated significant signal intensity decrease of tumors (white arrows) in T2WI after the injection. Prostate tumor-bearing nude mice injected with ssDNA-GoldMag showed no significant T2WI signal intensity changes (hollow arrows). Quantitative signal intensity measurement of T2WI for the tumors correspondingly at different time points ( B ). MRI represents magnetic resonance imaging; T2WI represents T2-weighted imaging; ssDNA-GoldMag represents random single strand DNA conjugated with GoldMag nanoparticles as negative control. ** P < 0.01, *** P < 0.001, **** P < 0.0001.
Article Snippet: MRI represents magnetic resonance imaging; T2WI represents T2-weighted imaging; ssDNA-GoldMag represents random single strand DNA conjugated with
Techniques: In Vivo, Injection, Magnetic Resonance Imaging, Imaging, Negative Control