Journal: EFSA Journal

Article Title: Scientific Opinion on Flavouring Group Evaluation 208 Revision 3 (FGE.208Rev3): consideration of genotoxicity data on alicyclic aldehydes with α,β‐unsaturation in ring/side‐chain and precursors from chemical subgroup 2.2 of FGE.19

doi: 10.2903/j.efsa.2019.5569

Figure Lengend Snippet: List of in vitro genotoxicity studies evaluated in FGE.208Rev2

Article Snippet: Myrtenal [05.106] , Bacterial reverse mutation assay , S . Typhimurium TA98, TA100, TA1535, TA1537 E. coli WP2uvrA , 1.5, 5, 15, 50, 150, 500, 1,500, and 5,000 μg/plate (a),(b) , Negative , BioReliance (2017) , Reliable without restriction. GLP study in compliance with OECD Test Guideline 471.

Techniques: In Vitro, Mutagenesis

Journal: EFSA Journal

Article Title: Scientific Opinion on Flavouring Group Evaluation 208 Revision 3 (FGE.208Rev3): consideration of genotoxicity data on alicyclic aldehydes with α,β‐unsaturation in ring/side‐chain and precursors from chemical subgroup 2.2 of FGE.19

doi: 10.2903/j.efsa.2019.5569

Figure Lengend Snippet: Summary of in vitro genotoxicity data evaluated in FGE.208Rev2

Article Snippet: Myrtenal [05.106] , Bacterial reverse mutation assay , S . Typhimurium TA98, TA100, TA1535, TA1537 E. coli WP2uvrA , 1.5, 5, 15, 50, 150, 500, 1,500, and 5,000 μg/plate (a),(b) , Negative , BioReliance (2017) , Reliable without restriction. GLP study in compliance with OECD Test Guideline 471.

Techniques: In Vitro, Concentration Assay, Mutagenesis

Journal: EFSA Journal

Article Title: Scientific Opinion on Flavouring Group Evaluation 208 Revision 3 (FGE.208Rev3): consideration of genotoxicity data on alicyclic aldehydes with α,β‐unsaturation in ring/side‐chain and precursors from chemical subgroup 2.2 of FGE.19

doi: 10.2903/j.efsa.2019.5569

Figure Lengend Snippet: List of genotoxicity studies evaluated in FGE.208Rev3

Article Snippet: Myrtenal [05.106] , Bacterial reverse mutation assay , S . Typhimurium TA98, TA100, TA1535, TA1537 E. coli WP2uvrA , 1.5, 5, 15, 50, 150, 500, 1,500, and 5,000 μg/plate (a),(b) , Negative , BioReliance (2017) , Reliable without restriction. GLP study in compliance with OECD Test Guideline 471.

Techniques: Mutagenesis, In Vivo, Single Cell Gel Electrophoresis

Journal: EFSA Journal

Article Title: Scientific Opinion on Flavouring Group Evaluation 208 Revision 3 (FGE.208Rev3): consideration of genotoxicity data on alicyclic aldehydes with α,β‐unsaturation in ring/side‐chain and precursors from chemical subgroup 2.2 of FGE.19

doi: 10.2903/j.efsa.2019.5569

Figure Lengend Snippet: Summary of in vitro genotoxicity data evaluated in FGE.208Rev3

Article Snippet: Myrtenal [05.106] , Bacterial reverse mutation assay , S . Typhimurium TA98, TA100, TA1535, TA1537 E. coli WP2uvrA , 1.5, 5, 15, 50, 150, 500, 1,500, and 5,000 μg/plate (a),(b) , Negative , BioReliance (2017) , Reliable without restriction. GLP study in compliance with OECD Test Guideline 471.

Techniques: In Vitro, Concentration Assay, Mutagenesis

Journal: Molecules

Article Title: Essential Oils as a Potential Neuroprotective Remedy for Age-Related Neurodegenerative Diseases: A Review

doi: 10.3390/molecules26041107

Figure Lengend Snippet: Effects of essential oils (EOs) on neurodegenerative diseases.

Article Snippet: 52. , Artemisia annua L. (Asteraceae) Glycyrrhiza glabra L. (Fabaceae) , [ ] , Cholinesterase inhibition assay (AChE—Ellman assay) , 1,8-cineole, carvacrol, myrtenal and verbenone apparently inhibited AChE; the highest inhibitory activity was observed for myrtenal (IC 50 = 0.17 mM). , This is the first report to show the potential of myrtenal present in the EO of A. annua L. or G. glabra L. as an AChE inhibitor..

Techniques: In Vitro, Gas Chromatography, Gas Chromatography-Mass Spectrometry, High Performance Liquid Chromatography, Inhibition, Activity Assay, Chromatography, Binding Assay, Viability Assay, Molecular Weight, Fluorescence, Microscopy, Encapsulation, Zeta Potential Analyzer, Nuclear Magnetic Resonance, Fractionation, Thin Layer Chromatography, Peroxidation Assay, Produced, Functional Assay, Isolation, Cell Culture, Imaging, Mass Spectrometry, Extraction, Concentration Assay, Positive Control, Antioxidant Activity Assay, Comparison, Formulation, Animal Model, In Vivo, Caspase-3 Activity Assay, Activation Assay, MTT Assay, Protein-Protein interactions, Control, Expressing, Mouse Assay, Injection, Staining, TUNEL Assay, Transgenic Assay, Marker, Histopathology, Saline, Negative Control, Derivative Assay, Modification, Multiple Displacement Amplification, Sensitive Assay, RNAi Assay, Western Blot, Over Expression, Enzyme-linked Immunosorbent Assay, Immunofluorescence, Microinjection, Immunohistochemistry, Membrane, Sandwich ELISA, Phospho-proteomics, Ex Vivo, In Silico, Resazurin Assay, Flow Cytometry, Liposomes, Mutagenesis, Labeling, Gene Expression, Solvent, Clinical Proteomics, TBARS Assay