Journal: Experimental Hematology & Oncology

Article Title: CTP synthase 2 predicts inferior survival and mediates DNA damage response via interacting with BRCA1 in chronic lymphocytic leukemia

doi: 10.1186/s40164-022-00364-0

Figure Lengend Snippet: Aberrantly increased level of cytidine triphosphate synthase (CTPS2) expression in chronic lymphocytic leukemia (CLL). A The relative ratio of CTPS2 mRNA in CLL patients versus that in purified normal CD19 + B cells derived from healthy donors. B Protein expression of CTPS2 in CLL primary cells and healthy donors. C – E CTPS2 was markedly upregulated in CLL public database. Analyses were based on GSE5006, GSE22529 and GSE55288, respectively. F Expression of CTPS2 in stable disease (SD) and progressive disease (PD) patients was elevated relative to partial response (PR) and complete response (CR) patients. Data were from the ICGC database. G – I CLL patients with higher Binet stage, unmutated IGHV and 11q23 − presented high CTPS2 expression (ICGC database). Data were shown as the mean ± SEM. ** p < 0.01, *** p < 0.001

Article Snippet: Cytidine-triphosphate (HY-125818, MCE) were soluble in sterile saline solution to the storage concentration at 10 mM.

Techniques: Expressing, Purification, Derivative Assay

Journal: eLife

Article Title: A robust method for particulate detection of a genetic tag for 3D electron microscopy

doi: 10.7554/eLife.64630

Figure Lengend Snippet:

Article Snippet: Chemical compound, drug , CTP , Chem-Impex , 00095 , .

Techniques: Transfection, Construct, Recombinant, Sequencing, In Vitro, Labeling, Electron Microscopy, Inhibition, Purification, Software