x5050 Search Results


rest inhibitor x5050  (MedChemExpress)
93
MedChemExpress rest inhibitor x5050
The REST-specific inhibitor <t>X5050</t> can alleviate renal fibrosis induced by UUO or TGF-β1. X5050 (10 mg/kg) or saline was injected into the C57BL/6J mice for 14 days after they received UUO or sham surgery. HK-2 cells were added with X5050 (100 μM) or PBS with or without TGF-β1 for 24 h. ( A and B ) Western blot analysis of α-SMA and FN in kidney tissues or HK-2 cells. ( C ) HE staining, Masson staining, immunofluorescence staining of FN, and immunohistochemical staining of α-SMA. Scale bar: 50 μm (HE), 25 μm (HE Zoom, Masson, α-SMA, and FN) ( n = 6). ( D-F ) Fibrotic area of Masson ( D ), α-SMA positive area ( E ) and FN positive area ( F ). Data are shown as mean ± SD and were analyzed by one-way ANOVA ( A - F )
Rest Inhibitor X5050, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/rest inhibitor x5050/product/MedChemExpress
Average 93 stars, based on 1 article reviews
rest inhibitor x5050 - by Bioz Stars, 2026-03
93/100 stars
  Buy from Supplier
x5050  (Molecular Biosciences Inc)
90
Molecular Biosciences Inc x5050
The REST-specific inhibitor <t>X5050</t> can alleviate renal fibrosis induced by UUO or TGF-β1. X5050 (10 mg/kg) or saline was injected into the C57BL/6J mice for 14 days after they received UUO or sham surgery. HK-2 cells were added with X5050 (100 μM) or PBS with or without TGF-β1 for 24 h. ( A and B ) Western blot analysis of α-SMA and FN in kidney tissues or HK-2 cells. ( C ) HE staining, Masson staining, immunofluorescence staining of FN, and immunohistochemical staining of α-SMA. Scale bar: 50 μm (HE), 25 μm (HE Zoom, Masson, α-SMA, and FN) ( n = 6). ( D-F ) Fibrotic area of Masson ( D ), α-SMA positive area ( E ) and FN positive area ( F ). Data are shown as mean ± SD and were analyzed by one-way ANOVA ( A - F )
X5050, supplied by Molecular Biosciences Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/x5050/product/Molecular Biosciences Inc
Average 90 stars, based on 1 article reviews
x5050 - by Bioz Stars, 2026-03
90/100 stars
  Buy from Supplier

Image Search Results


The REST-specific inhibitor X5050 can alleviate renal fibrosis induced by UUO or TGF-β1. X5050 (10 mg/kg) or saline was injected into the C57BL/6J mice for 14 days after they received UUO or sham surgery. HK-2 cells were added with X5050 (100 μM) or PBS with or without TGF-β1 for 24 h. ( A and B ) Western blot analysis of α-SMA and FN in kidney tissues or HK-2 cells. ( C ) HE staining, Masson staining, immunofluorescence staining of FN, and immunohistochemical staining of α-SMA. Scale bar: 50 μm (HE), 25 μm (HE Zoom, Masson, α-SMA, and FN) ( n = 6). ( D-F ) Fibrotic area of Masson ( D ), α-SMA positive area ( E ) and FN positive area ( F ). Data are shown as mean ± SD and were analyzed by one-way ANOVA ( A - F )

Journal: Cell Communication and Signaling : CCS

Article Title: REST contributes to renal fibrosis through inducing mitochondrial energy metabolism imbalance in tubular epithelial cells

doi: 10.1186/s12964-025-02166-3

Figure Lengend Snippet: The REST-specific inhibitor X5050 can alleviate renal fibrosis induced by UUO or TGF-β1. X5050 (10 mg/kg) or saline was injected into the C57BL/6J mice for 14 days after they received UUO or sham surgery. HK-2 cells were added with X5050 (100 μM) or PBS with or without TGF-β1 for 24 h. ( A and B ) Western blot analysis of α-SMA and FN in kidney tissues or HK-2 cells. ( C ) HE staining, Masson staining, immunofluorescence staining of FN, and immunohistochemical staining of α-SMA. Scale bar: 50 μm (HE), 25 μm (HE Zoom, Masson, α-SMA, and FN) ( n = 6). ( D-F ) Fibrotic area of Masson ( D ), α-SMA positive area ( E ) and FN positive area ( F ). Data are shown as mean ± SD and were analyzed by one-way ANOVA ( A - F )

Article Snippet: Litters of mice were randomly divided into 2 groups and injected with specific REST inhibitor X5050 (HY-136833, MCE, Shanghai, China) or saline separately.

Techniques: Saline, Injection, Western Blot, Staining, Immunofluorescence, Immunohistochemical staining