ws-12 Search Results


ws-12  (TargetMol)
N/A
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ws 12  (Alomone Labs)
93
Alomone Labs ws 12
Ws 12, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ws-12/WS+12/pm40405392-73-14-29
Average 93 stars, based on 1 article reviews
ws 12 - by Bioz Stars, 2026-09
93/100 stars
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ws 12  (Tocris)
94
Tocris ws 12
Ws 12, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ws-12/WS+12/pm22305677-100-15-16
Average 94 stars, based on 1 article reviews
ws 12 - by Bioz Stars, 2026-09
94/100 stars
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ws12 500 n m  (Santa Cruz Biotechnology)
90
Santa Cruz Biotechnology ws12 500 n m
Ws12 500 N M, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ws-12/WS+12/pmc09306780-246-36-40
Average 90 stars, based on 1 article reviews
ws12 500 n m - by Bioz Stars, 2026-09
90/100 stars
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1r 2 s 5 r n  (Tocris)
94
Tocris 1r 2 s 5 r n
1r 2 S 5 R N, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ws-12/WS+12/pmc11655194-108-14-23
Average 94 stars, based on 1 article reviews
1r 2 s 5 r n - by Bioz Stars, 2026-09
94/100 stars
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ws 12  (MedChemExpress)
92
MedChemExpress ws 12
Reduced expression and function of TRPM8 following paclitaxel treatment. ( A ) Representative photomicrographs of TRPM8 immunofluorescence staining on day 14 after Veh and PTX treatment. ( B ) Statistical analysis of the number of TRPM8-positive neurons in the fixed area (1 μm 2 ). Data were analyzed using a t -test. * p < 0.05, n = 5, 4. ( C ) Western blot analysis of TRPM8 protein levels in DRGs on day 14 after Veh and PTX treatment. TRPM8 expression was normalized to β-actin expression. Histograms show the relative amount of TRPM8 protein in Veh and PTX-treated rats. The data were analyzed using an unpaired t -test. *** p < 0.001, n = 5. ( D , F ) The response of DRG neurons to menthol was significantly reduced in the PTX-treated group compared with the Veh-treated group. ( D ) Representative images of the calcium signals in DRG neurons isolated from Veh and PTX-treated rats after menthol (200 μM) stimulation. White arrows indicate the DRG neurons responsive to menthol. ( F ) Statistical analysis of the F340/F380 ratio in the Veh and PTX groups following menthol stimulation. Data were analyzed using a two-way ANOVA followed by Bonferroni post hoc tests (3 independent experiments). *** p < 0.001, n = 26, 22. ( E , G ) The response of DRG neurons <t>to</t> <t>WS-12</t> (a selective agonist of TRPM8) was significantly decreased in the PTX-treated group compared with the Veh-treated group. ( E ) Representative calcium images of DRG neurons isolated from Veh- and PTX-treated rats after WS-12 (10 μM) stimulation. White arrows indicate the DRG neurons responsive to WS-12. ( G ) Statistical analysis of the F340/F380 ratio following WS-12 stimulation. Data were analyzed using a two-way ANOVA followed by Bonferroni post hoc tests, 3 independent experiments, *** p < 0.001, n = 7, 16. Scale bars in ( D , E ) represent 100 μm. Veh: vehicle, PTX: paclitaxel, BL: baseline.
Ws 12, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ws-12/Acoltremon/pmc11171746-173-12-16
Average 92 stars, based on 1 article reviews
ws 12 - by Bioz Stars, 2026-09
92/100 stars
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water-displacing rust preventive compound (sheath® ws12  (Birchwood Laboratories)
90
Birchwood Laboratories water-displacing rust preventive compound (sheath® ws12
Reduced expression and function of TRPM8 following paclitaxel treatment. ( A ) Representative photomicrographs of TRPM8 immunofluorescence staining on day 14 after Veh and PTX treatment. ( B ) Statistical analysis of the number of TRPM8-positive neurons in the fixed area (1 μm 2 ). Data were analyzed using a t -test. * p < 0.05, n = 5, 4. ( C ) Western blot analysis of TRPM8 protein levels in DRGs on day 14 after Veh and PTX treatment. TRPM8 expression was normalized to β-actin expression. Histograms show the relative amount of TRPM8 protein in Veh and PTX-treated rats. The data were analyzed using an unpaired t -test. *** p < 0.001, n = 5. ( D , F ) The response of DRG neurons to menthol was significantly reduced in the PTX-treated group compared with the Veh-treated group. ( D ) Representative images of the calcium signals in DRG neurons isolated from Veh and PTX-treated rats after menthol (200 μM) stimulation. White arrows indicate the DRG neurons responsive to menthol. ( F ) Statistical analysis of the F340/F380 ratio in the Veh and PTX groups following menthol stimulation. Data were analyzed using a two-way ANOVA followed by Bonferroni post hoc tests (3 independent experiments). *** p < 0.001, n = 26, 22. ( E , G ) The response of DRG neurons <t>to</t> <t>WS-12</t> (a selective agonist of TRPM8) was significantly decreased in the PTX-treated group compared with the Veh-treated group. ( E ) Representative calcium images of DRG neurons isolated from Veh- and PTX-treated rats after WS-12 (10 μM) stimulation. White arrows indicate the DRG neurons responsive to WS-12. ( G ) Statistical analysis of the F340/F380 ratio following WS-12 stimulation. Data were analyzed using a two-way ANOVA followed by Bonferroni post hoc tests, 3 independent experiments, *** p < 0.001, n = 7, 16. Scale bars in ( D , E ) represent 100 μm. Veh: vehicle, PTX: paclitaxel, BL: baseline.
Water Displacing Rust Preventive Compound (Sheath® Ws12, supplied by Birchwood Laboratories, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ws-12/water+displacing+rust+preventive+compound++sheath++ws12/us08691346-431-10-16
Average 90 stars, based on 1 article reviews
water-displacing rust preventive compound (sheath® ws12 - by Bioz Stars, 2026-09
90/100 stars
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ws12-2 speckle tracking  (HELIOS Klinikum Aue)
90
HELIOS Klinikum Aue ws12-2 speckle tracking
Reduced expression and function of TRPM8 following paclitaxel treatment. ( A ) Representative photomicrographs of TRPM8 immunofluorescence staining on day 14 after Veh and PTX treatment. ( B ) Statistical analysis of the number of TRPM8-positive neurons in the fixed area (1 μm 2 ). Data were analyzed using a t -test. * p < 0.05, n = 5, 4. ( C ) Western blot analysis of TRPM8 protein levels in DRGs on day 14 after Veh and PTX treatment. TRPM8 expression was normalized to β-actin expression. Histograms show the relative amount of TRPM8 protein in Veh and PTX-treated rats. The data were analyzed using an unpaired t -test. *** p < 0.001, n = 5. ( D , F ) The response of DRG neurons to menthol was significantly reduced in the PTX-treated group compared with the Veh-treated group. ( D ) Representative images of the calcium signals in DRG neurons isolated from Veh and PTX-treated rats after menthol (200 μM) stimulation. White arrows indicate the DRG neurons responsive to menthol. ( F ) Statistical analysis of the F340/F380 ratio in the Veh and PTX groups following menthol stimulation. Data were analyzed using a two-way ANOVA followed by Bonferroni post hoc tests (3 independent experiments). *** p < 0.001, n = 26, 22. ( E , G ) The response of DRG neurons <t>to</t> <t>WS-12</t> (a selective agonist of TRPM8) was significantly decreased in the PTX-treated group compared with the Veh-treated group. ( E ) Representative calcium images of DRG neurons isolated from Veh- and PTX-treated rats after WS-12 (10 μM) stimulation. White arrows indicate the DRG neurons responsive to WS-12. ( G ) Statistical analysis of the F340/F380 ratio following WS-12 stimulation. Data were analyzed using a two-way ANOVA followed by Bonferroni post hoc tests, 3 independent experiments, *** p < 0.001, n = 7, 16. Scale bars in ( D , E ) represent 100 μm. Veh: vehicle, PTX: paclitaxel, BL: baseline.
Ws12 2 Speckle Tracking, supplied by HELIOS Klinikum Aue, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ws-12/ws12+2+speckle+tracking/pm31645069-1016-0-21
Average 90 stars, based on 1 article reviews
ws12-2 speckle tracking - by Bioz Stars, 2026-09
90/100 stars
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enterobacter sp. ws12  (Verlag GmbH)
90
Verlag GmbH enterobacter sp. ws12
Reduced expression and function of TRPM8 following paclitaxel treatment. ( A ) Representative photomicrographs of TRPM8 immunofluorescence staining on day 14 after Veh and PTX treatment. ( B ) Statistical analysis of the number of TRPM8-positive neurons in the fixed area (1 μm 2 ). Data were analyzed using a t -test. * p < 0.05, n = 5, 4. ( C ) Western blot analysis of TRPM8 protein levels in DRGs on day 14 after Veh and PTX treatment. TRPM8 expression was normalized to β-actin expression. Histograms show the relative amount of TRPM8 protein in Veh and PTX-treated rats. The data were analyzed using an unpaired t -test. *** p < 0.001, n = 5. ( D , F ) The response of DRG neurons to menthol was significantly reduced in the PTX-treated group compared with the Veh-treated group. ( D ) Representative images of the calcium signals in DRG neurons isolated from Veh and PTX-treated rats after menthol (200 μM) stimulation. White arrows indicate the DRG neurons responsive to menthol. ( F ) Statistical analysis of the F340/F380 ratio in the Veh and PTX groups following menthol stimulation. Data were analyzed using a two-way ANOVA followed by Bonferroni post hoc tests (3 independent experiments). *** p < 0.001, n = 26, 22. ( E , G ) The response of DRG neurons <t>to</t> <t>WS-12</t> (a selective agonist of TRPM8) was significantly decreased in the PTX-treated group compared with the Veh-treated group. ( E ) Representative calcium images of DRG neurons isolated from Veh- and PTX-treated rats after WS-12 (10 μM) stimulation. White arrows indicate the DRG neurons responsive to WS-12. ( G ) Statistical analysis of the F340/F380 ratio following WS-12 stimulation. Data were analyzed using a two-way ANOVA followed by Bonferroni post hoc tests, 3 independent experiments, *** p < 0.001, n = 7, 16. Scale bars in ( D , E ) represent 100 μm. Veh: vehicle, PTX: paclitaxel, BL: baseline.
Enterobacter Sp. Ws12, supplied by Verlag GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ws-12/enterobacter+sp++ws12/pm24852724-146-17-22
Average 90 stars, based on 1 article reviews
enterobacter sp. ws12 - by Bioz Stars, 2026-09
90/100 stars
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ws12/04 systemische immunmodulation  (Forschungszentrum gmbh)
90
Forschungszentrum gmbh ws12/04 systemische immunmodulation
Reduced expression and function of TRPM8 following paclitaxel treatment. ( A ) Representative photomicrographs of TRPM8 immunofluorescence staining on day 14 after Veh and PTX treatment. ( B ) Statistical analysis of the number of TRPM8-positive neurons in the fixed area (1 μm 2 ). Data were analyzed using a t -test. * p < 0.05, n = 5, 4. ( C ) Western blot analysis of TRPM8 protein levels in DRGs on day 14 after Veh and PTX treatment. TRPM8 expression was normalized to β-actin expression. Histograms show the relative amount of TRPM8 protein in Veh and PTX-treated rats. The data were analyzed using an unpaired t -test. *** p < 0.001, n = 5. ( D , F ) The response of DRG neurons to menthol was significantly reduced in the PTX-treated group compared with the Veh-treated group. ( D ) Representative images of the calcium signals in DRG neurons isolated from Veh and PTX-treated rats after menthol (200 μM) stimulation. White arrows indicate the DRG neurons responsive to menthol. ( F ) Statistical analysis of the F340/F380 ratio in the Veh and PTX groups following menthol stimulation. Data were analyzed using a two-way ANOVA followed by Bonferroni post hoc tests (3 independent experiments). *** p < 0.001, n = 26, 22. ( E , G ) The response of DRG neurons <t>to</t> <t>WS-12</t> (a selective agonist of TRPM8) was significantly decreased in the PTX-treated group compared with the Veh-treated group. ( E ) Representative calcium images of DRG neurons isolated from Veh- and PTX-treated rats after WS-12 (10 μM) stimulation. White arrows indicate the DRG neurons responsive to WS-12. ( G ) Statistical analysis of the F340/F380 ratio following WS-12 stimulation. Data were analyzed using a two-way ANOVA followed by Bonferroni post hoc tests, 3 independent experiments, *** p < 0.001, n = 7, 16. Scale bars in ( D , E ) represent 100 μm. Veh: vehicle, PTX: paclitaxel, BL: baseline.
Ws12/04 Systemische Immunmodulation, supplied by Forschungszentrum gmbh, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ws-12/ws12+04+systemische+immunmodulation/pm17419850-4920-0-6
Average 90 stars, based on 1 article reviews
ws12/04 systemische immunmodulation - by Bioz Stars, 2026-09
90/100 stars
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ws12  (BOC Sciences)
N/A
WS12 is a potent TRPM8 agonist. It acts as a cooling agent with EC50 value of 193 nM. It robustly activated TRPM8 in low micromolar concentrations, thus displaying a higher potency and efficacy compared to
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ws 12  (Toronto Research Chemicals)
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Image Search Results


Reduced expression and function of TRPM8 following paclitaxel treatment. ( A ) Representative photomicrographs of TRPM8 immunofluorescence staining on day 14 after Veh and PTX treatment. ( B ) Statistical analysis of the number of TRPM8-positive neurons in the fixed area (1 μm 2 ). Data were analyzed using a t -test. * p < 0.05, n = 5, 4. ( C ) Western blot analysis of TRPM8 protein levels in DRGs on day 14 after Veh and PTX treatment. TRPM8 expression was normalized to β-actin expression. Histograms show the relative amount of TRPM8 protein in Veh and PTX-treated rats. The data were analyzed using an unpaired t -test. *** p < 0.001, n = 5. ( D , F ) The response of DRG neurons to menthol was significantly reduced in the PTX-treated group compared with the Veh-treated group. ( D ) Representative images of the calcium signals in DRG neurons isolated from Veh and PTX-treated rats after menthol (200 μM) stimulation. White arrows indicate the DRG neurons responsive to menthol. ( F ) Statistical analysis of the F340/F380 ratio in the Veh and PTX groups following menthol stimulation. Data were analyzed using a two-way ANOVA followed by Bonferroni post hoc tests (3 independent experiments). *** p < 0.001, n = 26, 22. ( E , G ) The response of DRG neurons to WS-12 (a selective agonist of TRPM8) was significantly decreased in the PTX-treated group compared with the Veh-treated group. ( E ) Representative calcium images of DRG neurons isolated from Veh- and PTX-treated rats after WS-12 (10 μM) stimulation. White arrows indicate the DRG neurons responsive to WS-12. ( G ) Statistical analysis of the F340/F380 ratio following WS-12 stimulation. Data were analyzed using a two-way ANOVA followed by Bonferroni post hoc tests, 3 independent experiments, *** p < 0.001, n = 7, 16. Scale bars in ( D , E ) represent 100 μm. Veh: vehicle, PTX: paclitaxel, BL: baseline.

Journal: International Journal of Molecular Sciences

Article Title: Roles of Thermosensitive Transient Receptor Channels TRPV1 and TRPM8 in Paclitaxel-Induced Peripheral Neuropathic Pain

doi: 10.3390/ijms25115813

Figure Lengend Snippet: Reduced expression and function of TRPM8 following paclitaxel treatment. ( A ) Representative photomicrographs of TRPM8 immunofluorescence staining on day 14 after Veh and PTX treatment. ( B ) Statistical analysis of the number of TRPM8-positive neurons in the fixed area (1 μm 2 ). Data were analyzed using a t -test. * p < 0.05, n = 5, 4. ( C ) Western blot analysis of TRPM8 protein levels in DRGs on day 14 after Veh and PTX treatment. TRPM8 expression was normalized to β-actin expression. Histograms show the relative amount of TRPM8 protein in Veh and PTX-treated rats. The data were analyzed using an unpaired t -test. *** p < 0.001, n = 5. ( D , F ) The response of DRG neurons to menthol was significantly reduced in the PTX-treated group compared with the Veh-treated group. ( D ) Representative images of the calcium signals in DRG neurons isolated from Veh and PTX-treated rats after menthol (200 μM) stimulation. White arrows indicate the DRG neurons responsive to menthol. ( F ) Statistical analysis of the F340/F380 ratio in the Veh and PTX groups following menthol stimulation. Data were analyzed using a two-way ANOVA followed by Bonferroni post hoc tests (3 independent experiments). *** p < 0.001, n = 26, 22. ( E , G ) The response of DRG neurons to WS-12 (a selective agonist of TRPM8) was significantly decreased in the PTX-treated group compared with the Veh-treated group. ( E ) Representative calcium images of DRG neurons isolated from Veh- and PTX-treated rats after WS-12 (10 μM) stimulation. White arrows indicate the DRG neurons responsive to WS-12. ( G ) Statistical analysis of the F340/F380 ratio following WS-12 stimulation. Data were analyzed using a two-way ANOVA followed by Bonferroni post hoc tests, 3 independent experiments, *** p < 0.001, n = 7, 16. Scale bars in ( D , E ) represent 100 μm. Veh: vehicle, PTX: paclitaxel, BL: baseline.

Article Snippet: A total of 10 μL of capsazepine (1 μg/μL, HY-15640; MCE) and WS-12 (1 μg/μL, HY-108449; MCE) or a vehicle control were given four times to each rat through the catheter.

Techniques: Expressing, Immunofluorescence, Staining, Western Blot, Isolation

Activation of TRPM8 significantly attenuated mechanical hypersensitivity in PIPNP. ( A , B ) Intrathecal injection of 10 μg of WS-12 significantly alleviated both static and dynamic mechanical pain. ( A ) Time course and statistical analysis of PWT in PTX-treated rats on days 8, 10, 12, and 14 after intrathecal injection of WS-12 or the control. ( B ) Time course and AUC analysis of the dynamic score in the PTX-treated rats following administration of WS-12 or the control. ( C , D ) Topical application of 1% menthol demonstrated a significant analgesic effect on paclitaxel-induced mechanical pain. ( C ) Time course of PWT and AUC analysis in the vehicle-treated, PTX-treated, and PTX treated with menthol application groups on days 7, 14, 21, and 28. ( D ) Time course and AUC statistical analysis of the dynamic score in the vehicle-treated, PTX-treated, and PTX treated with menthol application groups on days 7, 14, 21, and 28. The pink areas in the left panels of ( A – D ) indicate the period of making the PIPNP model. The data were analyzed using a two-way ANOVA followed by Bonferroni post hoc tests and an unpaired t -test. * p < 0.05, ** p < 0.01, *** p < 0.001, ## p < 0.01, ### p < 0.001. n = 8, 5 in ( A ); n = 11, 9 in ( B ); n = 6 in ( C ) and n = 5 in ( D ).

Journal: International Journal of Molecular Sciences

Article Title: Roles of Thermosensitive Transient Receptor Channels TRPV1 and TRPM8 in Paclitaxel-Induced Peripheral Neuropathic Pain

doi: 10.3390/ijms25115813

Figure Lengend Snippet: Activation of TRPM8 significantly attenuated mechanical hypersensitivity in PIPNP. ( A , B ) Intrathecal injection of 10 μg of WS-12 significantly alleviated both static and dynamic mechanical pain. ( A ) Time course and statistical analysis of PWT in PTX-treated rats on days 8, 10, 12, and 14 after intrathecal injection of WS-12 or the control. ( B ) Time course and AUC analysis of the dynamic score in the PTX-treated rats following administration of WS-12 or the control. ( C , D ) Topical application of 1% menthol demonstrated a significant analgesic effect on paclitaxel-induced mechanical pain. ( C ) Time course of PWT and AUC analysis in the vehicle-treated, PTX-treated, and PTX treated with menthol application groups on days 7, 14, 21, and 28. ( D ) Time course and AUC statistical analysis of the dynamic score in the vehicle-treated, PTX-treated, and PTX treated with menthol application groups on days 7, 14, 21, and 28. The pink areas in the left panels of ( A – D ) indicate the period of making the PIPNP model. The data were analyzed using a two-way ANOVA followed by Bonferroni post hoc tests and an unpaired t -test. * p < 0.05, ** p < 0.01, *** p < 0.001, ## p < 0.01, ### p < 0.001. n = 8, 5 in ( A ); n = 11, 9 in ( B ); n = 6 in ( C ) and n = 5 in ( D ).

Article Snippet: A total of 10 μL of capsazepine (1 μg/μL, HY-15640; MCE) and WS-12 (1 μg/μL, HY-108449; MCE) or a vehicle control were given four times to each rat through the catheter.

Techniques: Activation Assay, Injection, Control