Journal: Physiological Reports

Article Title: Inhibition of superoxide and iNOS augment cutaneous nitric oxide‐dependent vasodilation in non‐Hispanic black young adults

doi: 10.14814/phy2.16021

Figure Lengend Snippet: Group Microvascular endothelial function in non‐Hispanic Black ( n = 15) and White ( n = 15) young adults. Microvascular endothelial function was assessed as the plateau phase in response to local heating. The plateau was reduced in non‐Hispanic Black participants (circles) relative to non‐Hispanic White participants (triangles) at control sites ( p < 0.01). In non‐Hispanic Black participants, tempol increased the plateau relative to control ( p = 0.04, d = 1.09) but the plateau at tempol sites was still reduced relative to the tempol site in non‐Hispanic White participants ( p < 0.01). Compared to control, there was a significant increase in the plateau in non‐Hispanic Black participants at both the 1400 W sites and the tempol +1400 W sites (both p < 0.01). The plateau at 1400 W ( p < 0.01) and tempol +1400 W ( p = 0.04, d = 1.03) was greater than at tempol sites in non‐Hispanic Black participants. The magnitude of the increase at 1400 W ( p = 0.86) and tempol + 1400 W ( p = 0.71) sites was such that the plateau in non‐Hispanic Black participants was not different than the plateau in non‐Hispanic White participants. Data for women in each group are shown in white symbols and data for men in black symbols. Data were analyzed using a general linear model with factors of group x microdialysis site. There was a significant main effect for group ( p < 0.01) and microdialysis site ( p < 0.01) and a significant interaction effect ( p < 0.01). Data are shown as mean ± standard deviation (confidence intervals and effect sizes are in the main text). For clarity, only p ≤ 0.05 are shown on the graph.

Article Snippet: Skin blood flow was measured at each microdialysis site (left dorsal forearm) using 7‐array integrated laser‐Doppler probes (VP7b probes and VMS‐LDF2 monitor, Moor Instruments; Axminster, UK).

Techniques: Control, Standard Deviation

Journal: Physiological Reports

Article Title: Inhibition of superoxide and iNOS augment cutaneous nitric oxide‐dependent vasodilation in non‐Hispanic black young adults

doi: 10.14814/phy2.16021

Figure Lengend Snippet: Individual plateau responses to each microdialysis treatment in non‐Hispanic Black ( n = 15) and non‐Hispanic White ( n = 15) young adults. The plateau response to each microdialysis treatment is shown for each participant. Data for non‐Hispanic Black participants (top three panels) are shown as circles and data from non‐Hispanic White participants (bottom three panels) are shown as triangles. Data for women in each group are shown in white symbols and data for men in each group are shown in black symbols. See Figure and main text for means, standard deviations, and additional pairwise comparisons.

Article Snippet: Skin blood flow was measured at each microdialysis site (left dorsal forearm) using 7‐array integrated laser‐Doppler probes (VP7b probes and VMS‐LDF2 monitor, Moor Instruments; Axminster, UK).

Techniques:

Journal: Physiological Reports

Article Title: Inhibition of superoxide and iNOS augment cutaneous nitric oxide‐dependent vasodilation in non‐Hispanic black young adults

doi: 10.14814/phy2.16021

Figure Lengend Snippet: Calculated NO‐dependent vasodilation in non‐Hispanic Black ( n = 15) and White ( n = 15) young adults. NO‐dependent vasodilation was reduced in non‐Hispanic Black participants (circles) relative to non‐Hispanic White participants (triangles) at control sites (both p < 0.01). In non‐Hispanic Black participants, tempol increased NO‐dependent vasodilation relative to control ( p < 0.01) but this was still reduced relative to the tempol site in non‐Hispanic White participants ( p < 0.01). Compared to control, there was a significant increase in NO‐dependent vasodilation in non‐Hispanic Black participants at both the 1400 W sites and the tempol +1400 W sites (both p < 0.01). NO‐dependent vasodilation at 1400 W ( p = 0.04, d = 1.1) and tempol +1400 W ( p = 0.03, d = 1.22) sites was also greater than at tempol sites in non‐Hispanic Black participants. The magnitude of the increase at 1400 W ( p = 0.88) and tempol +1400 W ( p = 0.33) sites was such that the plateau in non‐Hispanic Black participants was not different than the plateau in non‐Hispanic White participants. Data for women in each group are shown in white symbols and data for men in black symbols. Data were analyzed using a general linear model with factors of group x microdialysis site. There was a significant main effect for group ( p < 0.01) and microdialysis site ( p < 0.01) and a significant interaction effect ( p < 0.01). Data are shown as mean ± standard deviation (confidence intervals and effect sizes are in the main text). For clarity, only p ≤ 0.05 are shown on the graph.

Article Snippet: Skin blood flow was measured at each microdialysis site (left dorsal forearm) using 7‐array integrated laser‐Doppler probes (VP7b probes and VMS‐LDF2 monitor, Moor Instruments; Axminster, UK).

Techniques: Control, Standard Deviation

Journal: Physiological Reports

Article Title: Inhibition of superoxide and iNOS augment cutaneous nitric oxide‐dependent vasodilation in non‐Hispanic black young adults

doi: 10.14814/phy2.16021

Figure Lengend Snippet: Individual NO‐dependent vasodilation to each microdialysis treatment in non‐Hispanic Black ( n = 15) and non‐Hispanic White ( n = 15) young adults. The calculated NO‐dependent vasodilation to each microdialysis treatment is shown for each participant. Data are shown as the response from control to each treatment site. Data for non‐Hispanic Black participants (top three panels) are shown as circles and data from non‐Hispanic White participants (bottom three panels) are shown as triangles. Data for women in each group are shown in white symbols and data for men in each group are shown in black symbols. See Figure and main text for means, standard deviations, and additional pairwise comparisons.

Article Snippet: Skin blood flow was measured at each microdialysis site (left dorsal forearm) using 7‐array integrated laser‐Doppler probes (VP7b probes and VMS‐LDF2 monitor, Moor Instruments; Axminster, UK).

Techniques: Control