Journal: Marine Drugs

Article Title: Hyaluronic Acid-like Skin Plumping and Radiance Benefits of a Porphyridium Sulfated Exopolysaccharide- and Natural PDRN-Rich Extract

doi: 10.3390/md24030099

Figure Lengend Snippet: Effect of the Porphyridium extract on ADORA2A receptor activation, as % of 6 µM NECA control. Lozenges indicate experimental data points (average of n = 3). Error bars indicate standard deviation. The curve represents a nonlinear least-squares fit equation (R 2 = 0.9963). The calculated EC50 point is shown by a lozenge enclosed in a square.

Article Snippet: In Visia image analysis, 1% Porphyridium extract in formulation demonstrated a very consistent advantage in enhancing skin radiance at all time points (+6%, p = 0.0077 at 1 h; +5% at 24 h, p = 0.0541; and +7% at D28, p = 0.0030) vs. the placebo formulation, which has little to no effect ( ).

Techniques: Activation Assay, Control, Standard Deviation

Journal: Marine Drugs

Article Title: Hyaluronic Acid-like Skin Plumping and Radiance Benefits of a Porphyridium Sulfated Exopolysaccharide- and Natural PDRN-Rich Extract

doi: 10.3390/md24030099

Figure Lengend Snippet: Effect of the Porphyridium extract on production of pro-collagen I ( a ) and collagen III ( b ) in NHDF cultures vs. untreated and positive controls. Average of n = 8–12 for pro-collagen I, and n = 15 for collagen III. Numbers above the bracket indicate the statistical p -values for the comparison indicated. MW = molecular weight; HA = hyaluronic acid.

Article Snippet: In Visia image analysis, 1% Porphyridium extract in formulation demonstrated a very consistent advantage in enhancing skin radiance at all time points (+6%, p = 0.0077 at 1 h; +5% at 24 h, p = 0.0541; and +7% at D28, p = 0.0030) vs. the placebo formulation, which has little to no effect ( ).

Techniques: Comparison, Molecular Weight

Journal: Marine Drugs

Article Title: Hyaluronic Acid-like Skin Plumping and Radiance Benefits of a Porphyridium Sulfated Exopolysaccharide- and Natural PDRN-Rich Extract

doi: 10.3390/md24030099

Figure Lengend Snippet: Effect of the Porphyridium extract on hyaluronic acid production in an NHDF culture vs. untreated control. Average of n = 15–16. Numbers above the bracket indicate the statistical p -values for the comparison indicated.

Article Snippet: In Visia image analysis, 1% Porphyridium extract in formulation demonstrated a very consistent advantage in enhancing skin radiance at all time points (+6%, p = 0.0077 at 1 h; +5% at 24 h, p = 0.0541; and +7% at D28, p = 0.0030) vs. the placebo formulation, which has little to no effect ( ).

Techniques: Control, Comparison

Journal: Marine Drugs

Article Title: Hyaluronic Acid-like Skin Plumping and Radiance Benefits of a Porphyridium Sulfated Exopolysaccharide- and Natural PDRN-Rich Extract

doi: 10.3390/md24030099

Figure Lengend Snippet: Effect of the Porphyridium extract on IL8 production in an NHDF culture stimulated with IL1-α vs. untreated control. Average of n = 9–12. Numbers above the bracket indicate the statistical p -values for the comparison indicated. MW = molecular weight; HA = hyaluronic acid.

Article Snippet: In Visia image analysis, 1% Porphyridium extract in formulation demonstrated a very consistent advantage in enhancing skin radiance at all time points (+6%, p = 0.0077 at 1 h; +5% at 24 h, p = 0.0541; and +7% at D28, p = 0.0030) vs. the placebo formulation, which has little to no effect ( ).

Techniques: Control, Comparison, Molecular Weight

Journal: Marine Drugs

Article Title: Hyaluronic Acid-like Skin Plumping and Radiance Benefits of a Porphyridium Sulfated Exopolysaccharide- and Natural PDRN-Rich Extract

doi: 10.3390/md24030099

Figure Lengend Snippet: Effect of the Porphyridium extract on autophagic flux in an aged NHDF culture vs. aged untreated and young NHDF controls. ( a ) Autophagic flux; ( b – d ) illustrative microscopy images: ( b ) young fibroblasts, ( c ) aged fibroblasts, ( d ) aged fibroblasts treated with 0.1% Porphyridium extract. Average of n = 36. Numbers above the brackets indicate the statistical p -values for the comparison indicated.

Article Snippet: In Visia image analysis, 1% Porphyridium extract in formulation demonstrated a very consistent advantage in enhancing skin radiance at all time points (+6%, p = 0.0077 at 1 h; +5% at 24 h, p = 0.0541; and +7% at D28, p = 0.0030) vs. the placebo formulation, which has little to no effect ( ).

Techniques: Microscopy, Comparison

Journal: Marine Drugs

Article Title: Hyaluronic Acid-like Skin Plumping and Radiance Benefits of a Porphyridium Sulfated Exopolysaccharide- and Natural PDRN-Rich Extract

doi: 10.3390/md24030099

Figure Lengend Snippet: Effect of the Porphyridium extract on the expression of autophagy-related genes in an aged NHDF culture vs. untreated control. As analyzed by the ΔΔCt method. Average of n = 3. Numbers above the brackets indicate the statistical p -values for the comparison indicated. ATG7 = autophagy-related 7; ATG8 = autophagy-related 8; DNM1L = dynamin-1-like; LAMP2A = lysosome-associated membrane protein 2; EPHA2 = ephrin receptor A2.

Article Snippet: In Visia image analysis, 1% Porphyridium extract in formulation demonstrated a very consistent advantage in enhancing skin radiance at all time points (+6%, p = 0.0077 at 1 h; +5% at 24 h, p = 0.0541; and +7% at D28, p = 0.0030) vs. the placebo formulation, which has little to no effect ( ).

Techniques: Expressing, Control, Comparison, Membrane

Journal: Marine Drugs

Article Title: Hyaluronic Acid-like Skin Plumping and Radiance Benefits of a Porphyridium Sulfated Exopolysaccharide- and Natural PDRN-Rich Extract

doi: 10.3390/md24030099

Figure Lengend Snippet: The Porphyridium extract delivers improvements in skin plumpness. The effect of topical treatment with the extract on skin plumpness was evaluated by Visia image analysis in a double-blind randomized clinical trial with placebo and HA benchmark controls. Average of n = 30–32. Numbers above the brackets indicate the statistical p -values for the comparison indicated. D0Timm = 1 h after first application; D1 = 24 h after first application; and D28 = after 28 days’ twice-daily application.

Article Snippet: In Visia image analysis, 1% Porphyridium extract in formulation demonstrated a very consistent advantage in enhancing skin radiance at all time points (+6%, p = 0.0077 at 1 h; +5% at 24 h, p = 0.0541; and +7% at D28, p = 0.0030) vs. the placebo formulation, which has little to no effect ( ).

Techniques: Comparison

Journal: Marine Drugs

Article Title: Hyaluronic Acid-like Skin Plumping and Radiance Benefits of a Porphyridium Sulfated Exopolysaccharide- and Natural PDRN-Rich Extract

doi: 10.3390/md24030099

Figure Lengend Snippet: The Porphyridium extract delivers improvements in skin density. The effect of topical treatment with the extract on skin density was evaluated by ultrasonography in a double-blind randomized clinical trial with placebo and HA benchmark controls. Average of n = 30–32. Numbers above the brackets indicate the statistical p -values for the comparison indicated. D28 = after 28 days’ twice-daily application.

Article Snippet: In Visia image analysis, 1% Porphyridium extract in formulation demonstrated a very consistent advantage in enhancing skin radiance at all time points (+6%, p = 0.0077 at 1 h; +5% at 24 h, p = 0.0541; and +7% at D28, p = 0.0030) vs. the placebo formulation, which has little to no effect ( ).

Techniques: Comparison

Journal: Marine Drugs

Article Title: Hyaluronic Acid-like Skin Plumping and Radiance Benefits of a Porphyridium Sulfated Exopolysaccharide- and Natural PDRN-Rich Extract

doi: 10.3390/md24030099

Figure Lengend Snippet: The Porphyridium extract delivers improvements in skin biomechanics. The effect of topical treatment with the extract on skin firmness ( a ) and elasticity ( b ) was evaluated by Cutometer in a double-blind randomized clinical trial with placebo and HA benchmark controls. Average of n = 30–32. Numbers above the brackets indicate the statistical p -values for the comparison indicated. D28 = after 28 days’ twice-daily application.

Article Snippet: In Visia image analysis, 1% Porphyridium extract in formulation demonstrated a very consistent advantage in enhancing skin radiance at all time points (+6%, p = 0.0077 at 1 h; +5% at 24 h, p = 0.0541; and +7% at D28, p = 0.0030) vs. the placebo formulation, which has little to no effect ( ).

Techniques: Comparison

Journal: Marine Drugs

Article Title: Hyaluronic Acid-like Skin Plumping and Radiance Benefits of a Porphyridium Sulfated Exopolysaccharide- and Natural PDRN-Rich Extract

doi: 10.3390/md24030099

Figure Lengend Snippet: The Porphyridium extract delivers improvements in skin barrier function. The effect of topical treatment with the extract on skin barrier function was evaluated by transepidermal water loss (TEWL) in a double-blind randomized clinical trial with placebo and HA benchmark controls. Average of n = 30–32. Numbers above the brackets indicate the statistical p -values for the comparison indicated. D0Timm = 1 h after first application; D1 = 24 h after first application; and D28 = after 28 days’ twice-daily application.

Article Snippet: In Visia image analysis, 1% Porphyridium extract in formulation demonstrated a very consistent advantage in enhancing skin radiance at all time points (+6%, p = 0.0077 at 1 h; +5% at 24 h, p = 0.0541; and +7% at D28, p = 0.0030) vs. the placebo formulation, which has little to no effect ( ).

Techniques: Comparison

Journal: Marine Drugs

Article Title: Hyaluronic Acid-like Skin Plumping and Radiance Benefits of a Porphyridium Sulfated Exopolysaccharide- and Natural PDRN-Rich Extract

doi: 10.3390/md24030099

Figure Lengend Snippet: The Porphyridium extract delivers improvements in skin radiance and skin tone. The effect of topical treatment with the extract on skin radiance and skin tone was evaluated by Visia image analysis in a double-blind randomized clinical trial with placebo and HA benchmark controls. ( a ) Skin radiance; ( b ) luminance (L*); ( c ) redness (a*). Average of n = 30–32. Numbers above the brackets indicate the statistical p -values for the comparison indicated. D0Timm = 1 h after first application; D1 = 24 h after first application; and D28 = after 28 days’ twice-daily application.

Article Snippet: In Visia image analysis, 1% Porphyridium extract in formulation demonstrated a very consistent advantage in enhancing skin radiance at all time points (+6%, p = 0.0077 at 1 h; +5% at 24 h, p = 0.0541; and +7% at D28, p = 0.0030) vs. the placebo formulation, which has little to no effect ( ).

Techniques: Comparison

Journal: Marine Drugs

Article Title: Hyaluronic Acid-like Skin Plumping and Radiance Benefits of a Porphyridium Sulfated Exopolysaccharide- and Natural PDRN-Rich Extract

doi: 10.3390/md24030099

Figure Lengend Snippet: The Porphyridium extract delivers improvements in skin wrinkling. The effect of topical treatment with the extract on wrinkle volume ( a ) and wrinkle counts ( b ) was evaluated by Visia-PRIMOS image analysis in a double-blind randomized clinical trial with placebo and HA benchmark controls. Average of n = 30–32. Numbers above the brackets indicate the statistical p -values for the comparison indicated. D0Timm = 1 h after first application; D1 = 24 h after first application; and D28 = after 28 days’ twice-daily application.

Article Snippet: In Visia image analysis, 1% Porphyridium extract in formulation demonstrated a very consistent advantage in enhancing skin radiance at all time points (+6%, p = 0.0077 at 1 h; +5% at 24 h, p = 0.0541; and +7% at D28, p = 0.0030) vs. the placebo formulation, which has little to no effect ( ).

Techniques: Comparison

Journal: Marine Drugs

Article Title: Hyaluronic Acid-like Skin Plumping and Radiance Benefits of a Porphyridium Sulfated Exopolysaccharide- and Natural PDRN-Rich Extract

doi: 10.3390/md24030099

Figure Lengend Snippet: The Porphyridium extract delivers improvements in skin roughness. The effect of topical treatment with the extract on skin roughness was evaluated by Visia-PRIMOS image analysis and clinician grading in a double-blind randomized clinical trial with placebo and HA benchmark controls. Average of n = 30–32. Numbers above the brackets indicate the statistical p -values for the comparison indicated. ( a ) Visia-PRIMOS image analysis (Ra index); ( b ) clinician grading.

Article Snippet: In Visia image analysis, 1% Porphyridium extract in formulation demonstrated a very consistent advantage in enhancing skin radiance at all time points (+6%, p = 0.0077 at 1 h; +5% at 24 h, p = 0.0541; and +7% at D28, p = 0.0030) vs. the placebo formulation, which has little to no effect ( ).

Techniques: Comparison

Journal: Marine Drugs

Article Title: Hyaluronic Acid-like Skin Plumping and Radiance Benefits of a Porphyridium Sulfated Exopolysaccharide- and Natural PDRN-Rich Extract

doi: 10.3390/md24030099

Figure Lengend Snippet: The Porphyridium extract delivers improvements in skin spots. The effect of topical treatment with the extract on skin spot counts was evaluated by Visia image analysis in a double-blind randomized clinical trial with placebo and HA benchmark controls. Average of n = 30–32. Numbers above the brackets indicate the statistical p -values for the comparison indicated. ( a ) Visible spot counts; ( b ) visible spot areas; ( c ) red spot counts.

Article Snippet: In Visia image analysis, 1% Porphyridium extract in formulation demonstrated a very consistent advantage in enhancing skin radiance at all time points (+6%, p = 0.0077 at 1 h; +5% at 24 h, p = 0.0541; and +7% at D28, p = 0.0030) vs. the placebo formulation, which has little to no effect ( ).

Techniques: Comparison

Journal: Aesthetic Surgery Journal. Open Forum

Article Title: Use of VISIA-CR Generation 5 in Aesthetic Skin Assessment: A Single-Case Review

doi: 10.1093/asjof/ojag034

Figure Lengend Snippet: Standardized patient positioning during image acquisition using the VISIA-CR 5 system to capture (A) left oblique, (B) frontal, and (C) right oblique views.

Article Snippet: All parameter values were generated directly from the built-in VISIA-CR 5 analytical software.

Techniques:

Journal: Aesthetic Surgery Journal. Open Forum

Article Title: Use of VISIA-CR Generation 5 in Aesthetic Skin Assessment: A Single-Case Review

doi: 10.1093/asjof/ojag034

Figure Lengend Snippet: Simulated patient photograph showing the calculations for intensity-related parameters provided by the VISIA-CR 5 imaging system: (A) mean intensity (MI), (B) background intensity (BI), (C) mean contrast intensity (MCI), and (D) intensity.

Article Snippet: All parameter values were generated directly from the built-in VISIA-CR 5 analytical software.

Techniques: Imaging

Journal: Aesthetic Surgery Journal. Open Forum

Article Title: Use of VISIA-CR Generation 5 in Aesthetic Skin Assessment: A Single-Case Review

doi: 10.1093/asjof/ojag034

Figure Lengend Snippet: Simulated patient photograph showing the calculations for feature (A) fractional area and (B) score provided by the VISIA-CR 5 imaging system.

Article Snippet: All parameter values were generated directly from the built-in VISIA-CR 5 analytical software.

Techniques: Imaging

Journal: Aesthetic Surgery Journal. Open Forum

Article Title: Use of VISIA-CR Generation 5 in Aesthetic Skin Assessment: A Single-Case Review

doi: 10.1093/asjof/ojag034

Figure Lengend Snippet: Percent change in (A) mean contrast intensity, (B) fractional area, (C) count, and (D) score of skin features at 3 months using the VISIA-CR 5 imaging system.

Article Snippet: All parameter values were generated directly from the built-in VISIA-CR 5 analytical software.

Techniques: Imaging

Journal: Lasers in Surgery and Medicine

Article Title: A Novel Neurocosmetic Postprocedure Cream for Optimal Recovery and Tolerability From Energy‐Based Devices

doi: 10.1002/lsm.70078

Figure Lengend Snippet: Hybrid Fractional Laser Study (Atlanta, Georgia): VISIA® RBX® Red Feature image analysis results across subjects for the neurocosmetic postprocedure cream (NPPC)‐treated side. A standardized cheek area of each subject's left and right facial sides from cross‐polarized light photographs was used for analysis. A reduction in mean red intensity compared to postprocedure product application is an improvement. Statistical analysis of data demonstrated p = 0.18, nonsignificant (ns).

Article Snippet: For Dallas, Texas, Figure shows VISIA® Red Areas images of a subject 58 years of age with FST II.

Techniques: Cream

Journal: Lasers in Surgery and Medicine

Article Title: A Novel Neurocosmetic Postprocedure Cream for Optimal Recovery and Tolerability From Energy‐Based Devices

doi: 10.1002/lsm.70078

Figure Lengend Snippet: Hybrid Fractional Laser Study (Dallas, Texas): VISIA® Red Areas images of a female subject aged 58 years, Fitzpatrick Skin Type II. Red Areas images were obtained using clinical photography taken under standard light, and a standardized tear‐drop shape of the right and left cheek was used for redness analysis in ImageJ. The subject applied the neurocosmetic postprocedure cream (NPPC) to the right side of the face (A–D) and the comparator moisturizer (CM) to the left side (E–H), as per randomization. Photographs were taken pre‐procedure (A, E); postprocedure product application (B, F); Day 1 postprocedure (C, G); Day 7 postprocedure (D, H).

Article Snippet: For Dallas, Texas, Figure shows VISIA® Red Areas images of a subject 58 years of age with FST II.

Techniques: Cream

Journal: Lasers in Surgery and Medicine

Article Title: A Novel Neurocosmetic Postprocedure Cream for Optimal Recovery and Tolerability From Energy‐Based Devices

doi: 10.1002/lsm.70078

Figure Lengend Snippet: Hybrid Fractional Laser Study (Dallas, Texas): ImageJ analysis of VISIA® Red Areas images across subjects for the neurocosmetic postprocedure cream‐treated side. Improvement (reduction) in redness compared to postprocedure product application. Significance achieved at * p ≤ 0.05.

Article Snippet: For Dallas, Texas, Figure shows VISIA® Red Areas images of a subject 58 years of age with FST II.

Techniques: Cream

Journal: Lasers in Surgery and Medicine

Article Title: A Novel Neurocosmetic Postprocedure Cream for Optimal Recovery and Tolerability From Energy‐Based Devices

doi: 10.1002/lsm.70078

Figure Lengend Snippet: Hybrid Fractional Laser Study (Atlanta, Georgia): VISIA® RBX® Red Feature image analysis results across subjects for the neurocosmetic postprocedure cream (NPPC)‐treated side. A standardized cheek area of each subject's left and right facial sides from cross‐polarized light photographs was used for analysis. A reduction in mean red intensity compared to postprocedure product application is an improvement. Statistical analysis of data demonstrated p = 0.18, nonsignificant (ns).

Article Snippet: In Atlanta, Georgia, VISIA® RBX® Red Feature image analysis across all subjects for the NPPC side showed mean red intensity decreased (improved) by a median percent of 4.2% by Day 1 and 13.2% by Day 7 postprocedure compared to postprocedure product application (Figure ).

Techniques: Cream