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Fig. 4. Cumulative concentration-response curves to <t>CNP</t> in PA and PV isolated from late-gestation fetal lambs. All vessels were pre- treated <t>with</t> <t>indomethacin,</t> propranolol, and N-nitro-L-arginine (L-NNA). Relaxations are expressed as percentage of plateau norepi- nephrine (NE) constriction. n, No. of animals. PV relax significantly better than PA to CNP.
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Fig. 4. Cumulative concentration-response curves to <t>CNP</t> in PA and PV isolated from late-gestation fetal lambs. All vessels were pre- treated <t>with</t> <t>indomethacin,</t> propranolol, and N-nitro-L-arginine (L-NNA). Relaxations are expressed as percentage of plateau norepi- nephrine (NE) constriction. n, No. of animals. PV relax significantly better than PA to CNP.
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Fig. 4. Cumulative concentration-response curves to <t>CNP</t> in PA and PV isolated from late-gestation fetal lambs. All vessels were pre- treated <t>with</t> <t>indomethacin,</t> propranolol, and N-nitro-L-arginine (L-NNA). Relaxations are expressed as percentage of plateau norepi- nephrine (NE) constriction. n, No. of animals. PV relax significantly better than PA to CNP.
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Fig. 4. Cumulative concentration-response curves to <t>CNP</t> in PA and PV isolated from late-gestation fetal lambs. All vessels were pre- treated <t>with</t> <t>indomethacin,</t> propranolol, and N-nitro-L-arginine (L-NNA). Relaxations are expressed as percentage of plateau norepi- nephrine (NE) constriction. n, No. of animals. PV relax significantly better than PA to CNP.
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Fig. 4. Cumulative concentration-response curves to <t>CNP</t> in PA and PV isolated from late-gestation fetal lambs. All vessels were pre- treated <t>with</t> <t>indomethacin,</t> propranolol, and N-nitro-L-arginine (L-NNA). Relaxations are expressed as percentage of plateau norepi- nephrine (NE) constriction. n, No. of animals. PV relax significantly better than PA to CNP.
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Fig. 4. Cumulative concentration-response curves to <t>CNP</t> in PA and PV isolated from late-gestation fetal lambs. All vessels were pre- treated <t>with</t> <t>indomethacin,</t> propranolol, and N-nitro-L-arginine (L-NNA). Relaxations are expressed as percentage of plateau norepi- nephrine (NE) constriction. n, No. of animals. PV relax significantly better than PA to CNP.
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Fig. 4. Cumulative concentration-response curves to <t>CNP</t> in PA and PV isolated from late-gestation fetal lambs. All vessels were pre- treated <t>with</t> <t>indomethacin,</t> propranolol, and N-nitro-L-arginine (L-NNA). Relaxations are expressed as percentage of plateau norepi- nephrine (NE) constriction. n, No. of animals. PV relax significantly better than PA to CNP.
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Fig. 4. Cumulative concentration-response curves to <t>CNP</t> in PA and PV isolated from late-gestation fetal lambs. All vessels were pre- treated <t>with</t> <t>indomethacin,</t> propranolol, and N-nitro-L-arginine (L-NNA). Relaxations are expressed as percentage of plateau norepi- nephrine (NE) constriction. n, No. of animals. PV relax significantly better than PA to CNP.
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Fig. 4. Cumulative concentration-response curves to <t>CNP</t> in PA and PV isolated from late-gestation fetal lambs. All vessels were pre- treated <t>with</t> <t>indomethacin,</t> propranolol, and N-nitro-L-arginine (L-NNA). Relaxations are expressed as percentage of plateau norepi- nephrine (NE) constriction. n, No. of animals. PV relax significantly better than PA to CNP.
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Image Search Results


Fig. 4. Cumulative concentration-response curves to CNP in PA and PV isolated from late-gestation fetal lambs. All vessels were pre- treated with indomethacin, propranolol, and N-nitro-L-arginine (L-NNA). Relaxations are expressed as percentage of plateau norepi- nephrine (NE) constriction. n, No. of animals. PV relax significantly better than PA to CNP.

Journal: American Journal of Physiology-Lung Cellular and Molecular Physiology

Article Title: C-type natriuretic peptide system in fetal ovine pulmonary vasculature

doi: 10.1152/ajplung.2001.281.2.l361

Figure Lengend Snippet: Fig. 4. Cumulative concentration-response curves to CNP in PA and PV isolated from late-gestation fetal lambs. All vessels were pre- treated with indomethacin, propranolol, and N-nitro-L-arginine (L-NNA). Relaxations are expressed as percentage of plateau norepi- nephrine (NE) constriction. n, No. of animals. PV relax significantly better than PA to CNP.

Article Snippet: The following pharmacological agents were used: indomethacin, DL-propranolol, N-nitro-L-arginine (L-NNA), L-norepinephrine hydrochloride, ANP (rat ANP 1–28), and CNP (human CNP 22; Peptides International, Louisville, KY).

Techniques: Concentration Assay, Isolation

Fig. 7. Cumulative concentration-response curves to CNP in PA (A) and PV (B) isolated from late-gestation fetal lambs in the presence and absence of protein kinase G inhibitor, Rp-b-phenyl-1-N2-etheno- 8-bromoguanosine 39,59-cyclic monophosphorothionate (Rp-8-Br- PET-cGMPS, PET; 3 3 1025 M). All vessels were pretreated with indomethacin, propranolol, and L-NNA. Relaxations are expressed as percentage of plateau NE constriction. n, No. of animals. Pretreat- ment with Rp-8-Br-PET-cGMPS results in significant inhibition of CNP-mediated relaxation in PA and PV.

Journal: American Journal of Physiology-Lung Cellular and Molecular Physiology

Article Title: C-type natriuretic peptide system in fetal ovine pulmonary vasculature

doi: 10.1152/ajplung.2001.281.2.l361

Figure Lengend Snippet: Fig. 7. Cumulative concentration-response curves to CNP in PA (A) and PV (B) isolated from late-gestation fetal lambs in the presence and absence of protein kinase G inhibitor, Rp-b-phenyl-1-N2-etheno- 8-bromoguanosine 39,59-cyclic monophosphorothionate (Rp-8-Br- PET-cGMPS, PET; 3 3 1025 M). All vessels were pretreated with indomethacin, propranolol, and L-NNA. Relaxations are expressed as percentage of plateau NE constriction. n, No. of animals. Pretreat- ment with Rp-8-Br-PET-cGMPS results in significant inhibition of CNP-mediated relaxation in PA and PV.

Article Snippet: The following pharmacological agents were used: indomethacin, DL-propranolol, N-nitro-L-arginine (L-NNA), L-norepinephrine hydrochloride, ANP (rat ANP 1–28), and CNP (human CNP 22; Peptides International, Louisville, KY).

Techniques: Concentration Assay, Isolation, Inhibition

Fig. 6. Cumulative concentration-response curves to CNP in PA (A) and PV (B) isolated from late-gestation fetal lambs in the presence and absence of NPR-particulate guanylate cyclase inhibitor (HS- 142-1; 2 3 1025 M). All vessels were pretreated with indomethacin, propranolol, and L-NNA. Relaxations are expressed as percentage of plateau NE constriction. n, No. of animals. Pretreatment with HS- 142-1 results in significant inhibition of CNP-mediated relaxation in PA and PV.

Journal: American Journal of Physiology-Lung Cellular and Molecular Physiology

Article Title: C-type natriuretic peptide system in fetal ovine pulmonary vasculature

doi: 10.1152/ajplung.2001.281.2.l361

Figure Lengend Snippet: Fig. 6. Cumulative concentration-response curves to CNP in PA (A) and PV (B) isolated from late-gestation fetal lambs in the presence and absence of NPR-particulate guanylate cyclase inhibitor (HS- 142-1; 2 3 1025 M). All vessels were pretreated with indomethacin, propranolol, and L-NNA. Relaxations are expressed as percentage of plateau NE constriction. n, No. of animals. Pretreatment with HS- 142-1 results in significant inhibition of CNP-mediated relaxation in PA and PV.

Article Snippet: The following pharmacological agents were used: indomethacin, DL-propranolol, N-nitro-L-arginine (L-NNA), L-norepinephrine hydrochloride, ANP (rat ANP 1–28), and CNP (human CNP 22; Peptides International, Louisville, KY).

Techniques: Concentration Assay, Isolation, Inhibition