ube2d3 Search Results


e2 conjugase  (R&D Systems)
94
R&D Systems e2 conjugase
E2 Conjugase, supplied by R&D Systems, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ube2d3  (Proteintech)
93
Proteintech ube2d3
Copper metabolism related genes DLD and <t>UBE2D3</t> act as protective factors in KIRC. (A) The OS Kaplan-Meier curve of DLD genes. (B) The ROC curve of DLD gene. (C) The Kaplan-Meier curve (OS) of UBE2D3 gene. The ROC curve of UBE2D3 gene (D) shows the differential expression of UBE2D3 gene at different T stages (E). (F) The expression differences of gene UBE2D3 in different G stages. (G) The calibration curve of the Norman plot is used to predict 1-, 3-, and 5-year survival rates. (H) By drawing a line graph, we predicted the OS period over a time range of 1-, 3-, and 5-year. Each risk factor corresponds to a point axis by drawing a line on the graph. *, P<0.05; **, P<0.01; ***, P<0.001. AUC, area under the curve; CI, confidence interval; G, grade; H, high; HR, hazard ratio; KIRC, kidney renal clear cell carcinoma; L, low; OS, overall survival; ROC, receiver operating characteristic; T, tumor.
Ube2d3, supplied by Proteintech, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 93 stars, based on 1 article reviews
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ubiquitin conjugating enzymeubch5c  (Boston Biochem)
95
Boston Biochem ubiquitin conjugating enzymeubch5c
Copper metabolism related genes DLD and <t>UBE2D3</t> act as protective factors in KIRC. (A) The OS Kaplan-Meier curve of DLD genes. (B) The ROC curve of DLD gene. (C) The Kaplan-Meier curve (OS) of UBE2D3 gene. The ROC curve of UBE2D3 gene (D) shows the differential expression of UBE2D3 gene at different T stages (E). (F) The expression differences of gene UBE2D3 in different G stages. (G) The calibration curve of the Norman plot is used to predict 1-, 3-, and 5-year survival rates. (H) By drawing a line graph, we predicted the OS period over a time range of 1-, 3-, and 5-year. Each risk factor corresponds to a point axis by drawing a line on the graph. *, P<0.05; **, P<0.01; ***, P<0.001. AUC, area under the curve; CI, confidence interval; G, grade; H, high; HR, hazard ratio; KIRC, kidney renal clear cell carcinoma; L, low; OS, overall survival; ROC, receiver operating characteristic; T, tumor.
Ubiquitin Conjugating Enzymeubch5c, supplied by Boston Biochem, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 95 stars, based on 1 article reviews
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recombinant human ubiquitin conjugating enzyme e2 ubch5c p00347  (Beijing Solarbio Science)
92
Beijing Solarbio Science recombinant human ubiquitin conjugating enzyme e2 ubch5c p00347
Copper metabolism related genes DLD and <t>UBE2D3</t> act as protective factors in KIRC. (A) The OS Kaplan-Meier curve of DLD genes. (B) The ROC curve of DLD gene. (C) The Kaplan-Meier curve (OS) of UBE2D3 gene. The ROC curve of UBE2D3 gene (D) shows the differential expression of UBE2D3 gene at different T stages (E). (F) The expression differences of gene UBE2D3 in different G stages. (G) The calibration curve of the Norman plot is used to predict 1-, 3-, and 5-year survival rates. (H) By drawing a line graph, we predicted the OS period over a time range of 1-, 3-, and 5-year. Each risk factor corresponds to a point axis by drawing a line on the graph. *, P<0.05; **, P<0.01; ***, P<0.001. AUC, area under the curve; CI, confidence interval; G, grade; H, high; HR, hazard ratio; KIRC, kidney renal clear cell carcinoma; L, low; OS, overall survival; ROC, receiver operating characteristic; T, tumor.
Recombinant Human Ubiquitin Conjugating Enzyme E2 Ubch5c P00347, supplied by Beijing Solarbio Science, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/recombinant human ubiquitin conjugating enzyme e2 ubch5c p00347/product/Beijing Solarbio Science
Average 92 stars, based on 1 article reviews
recombinant human ubiquitin conjugating enzyme e2 ubch5c p00347 - by Bioz Stars, 2026-04
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ube2d3  (Addgene inc)
92
Addgene inc ube2d3
Copper metabolism related genes DLD and <t>UBE2D3</t> act as protective factors in KIRC. (A) The OS Kaplan-Meier curve of DLD genes. (B) The ROC curve of DLD gene. (C) The Kaplan-Meier curve (OS) of UBE2D3 gene. The ROC curve of UBE2D3 gene (D) shows the differential expression of UBE2D3 gene at different T stages (E). (F) The expression differences of gene UBE2D3 in different G stages. (G) The calibration curve of the Norman plot is used to predict 1-, 3-, and 5-year survival rates. (H) By drawing a line graph, we predicted the OS period over a time range of 1-, 3-, and 5-year. Each risk factor corresponds to a point axis by drawing a line on the graph. *, P<0.05; **, P<0.01; ***, P<0.001. AUC, area under the curve; CI, confidence interval; G, grade; H, high; HR, hazard ratio; KIRC, kidney renal clear cell carcinoma; L, low; OS, overall survival; ROC, receiver operating characteristic; T, tumor.
Ube2d3, supplied by Addgene inc, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 92 stars, based on 1 article reviews
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ube2d3 expression  (Santa Cruz Biotechnology)
93
Santa Cruz Biotechnology ube2d3 expression
Copper metabolism related genes DLD and <t>UBE2D3</t> act as protective factors in KIRC. (A) The OS Kaplan-Meier curve of DLD genes. (B) The ROC curve of DLD gene. (C) The Kaplan-Meier curve (OS) of UBE2D3 gene. The ROC curve of UBE2D3 gene (D) shows the differential expression of UBE2D3 gene at different T stages (E). (F) The expression differences of gene UBE2D3 in different G stages. (G) The calibration curve of the Norman plot is used to predict 1-, 3-, and 5-year survival rates. (H) By drawing a line graph, we predicted the OS period over a time range of 1-, 3-, and 5-year. Each risk factor corresponds to a point axis by drawing a line on the graph. *, P<0.05; **, P<0.01; ***, P<0.001. AUC, area under the curve; CI, confidence interval; G, grade; H, high; HR, hazard ratio; KIRC, kidney renal clear cell carcinoma; L, low; OS, overall survival; ROC, receiver operating characteristic; T, tumor.
Ube2d3 Expression, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 93 stars, based on 1 article reviews
ube2d3 expression - by Bioz Stars, 2026-04
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antibodies nbp1 55276  (Novus Biologicals)
93
Novus Biologicals antibodies nbp1 55276
Copper metabolism related genes DLD and <t>UBE2D3</t> act as protective factors in KIRC. (A) The OS Kaplan-Meier curve of DLD genes. (B) The ROC curve of DLD gene. (C) The Kaplan-Meier curve (OS) of UBE2D3 gene. The ROC curve of UBE2D3 gene (D) shows the differential expression of UBE2D3 gene at different T stages (E). (F) The expression differences of gene UBE2D3 in different G stages. (G) The calibration curve of the Norman plot is used to predict 1-, 3-, and 5-year survival rates. (H) By drawing a line graph, we predicted the OS period over a time range of 1-, 3-, and 5-year. Each risk factor corresponds to a point axis by drawing a line on the graph. *, P<0.05; **, P<0.01; ***, P<0.001. AUC, area under the curve; CI, confidence interval; G, grade; H, high; HR, hazard ratio; KIRC, kidney renal clear cell carcinoma; L, low; OS, overall survival; ROC, receiver operating characteristic; T, tumor.
Antibodies Nbp1 55276, supplied by Novus Biologicals, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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h00007323 m01  (Novus Biologicals)
93
Novus Biologicals h00007323 m01
Copper metabolism related genes DLD and <t>UBE2D3</t> act as protective factors in KIRC. (A) The OS Kaplan-Meier curve of DLD genes. (B) The ROC curve of DLD gene. (C) The Kaplan-Meier curve (OS) of UBE2D3 gene. The ROC curve of UBE2D3 gene (D) shows the differential expression of UBE2D3 gene at different T stages (E). (F) The expression differences of gene UBE2D3 in different G stages. (G) The calibration curve of the Norman plot is used to predict 1-, 3-, and 5-year survival rates. (H) By drawing a line graph, we predicted the OS period over a time range of 1-, 3-, and 5-year. Each risk factor corresponds to a point axis by drawing a line on the graph. *, P<0.05; **, P<0.01; ***, P<0.001. AUC, area under the curve; CI, confidence interval; G, grade; H, high; HR, hazard ratio; KIRC, kidney renal clear cell carcinoma; L, low; OS, overall survival; ROC, receiver operating characteristic; T, tumor.
H00007323 M01, supplied by Novus Biologicals, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 93 stars, based on 1 article reviews
h00007323 m01 - by Bioz Stars, 2026-04
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crispr product  (Santa Cruz Biotechnology)
93
Santa Cruz Biotechnology crispr product
Copper metabolism related genes DLD and <t>UBE2D3</t> act as protective factors in KIRC. (A) The OS Kaplan-Meier curve of DLD genes. (B) The ROC curve of DLD gene. (C) The Kaplan-Meier curve (OS) of UBE2D3 gene. The ROC curve of UBE2D3 gene (D) shows the differential expression of UBE2D3 gene at different T stages (E). (F) The expression differences of gene UBE2D3 in different G stages. (G) The calibration curve of the Norman plot is used to predict 1-, 3-, and 5-year survival rates. (H) By drawing a line graph, we predicted the OS period over a time range of 1-, 3-, and 5-year. Each risk factor corresponds to a point axis by drawing a line on the graph. *, P<0.05; **, P<0.01; ***, P<0.001. AUC, area under the curve; CI, confidence interval; G, grade; H, high; HR, hazard ratio; KIRC, kidney renal clear cell carcinoma; L, low; OS, overall survival; ROC, receiver operating characteristic; T, tumor.
Crispr Product, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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mouse anti ubch5c antibody  (Novus Biologicals)
90
Novus Biologicals mouse anti ubch5c antibody
Copper metabolism related genes DLD and <t>UBE2D3</t> act as protective factors in KIRC. (A) The OS Kaplan-Meier curve of DLD genes. (B) The ROC curve of DLD gene. (C) The Kaplan-Meier curve (OS) of UBE2D3 gene. The ROC curve of UBE2D3 gene (D) shows the differential expression of UBE2D3 gene at different T stages (E). (F) The expression differences of gene UBE2D3 in different G stages. (G) The calibration curve of the Norman plot is used to predict 1-, 3-, and 5-year survival rates. (H) By drawing a line graph, we predicted the OS period over a time range of 1-, 3-, and 5-year. Each risk factor corresponds to a point axis by drawing a line on the graph. *, P<0.05; **, P<0.01; ***, P<0.001. AUC, area under the curve; CI, confidence interval; G, grade; H, high; HR, hazard ratio; KIRC, kidney renal clear cell carcinoma; L, low; OS, overall survival; ROC, receiver operating characteristic; T, tumor.
Mouse Anti Ubch5c Antibody, supplied by Novus Biologicals, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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mouse anti ubch5c antibody - by Bioz Stars, 2026-04
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ubch5c ube2d3  (R&D Systems)
92
R&D Systems ubch5c ube2d3
Copper metabolism related genes DLD and <t>UBE2D3</t> act as protective factors in KIRC. (A) The OS Kaplan-Meier curve of DLD genes. (B) The ROC curve of DLD gene. (C) The Kaplan-Meier curve (OS) of UBE2D3 gene. The ROC curve of UBE2D3 gene (D) shows the differential expression of UBE2D3 gene at different T stages (E). (F) The expression differences of gene UBE2D3 in different G stages. (G) The calibration curve of the Norman plot is used to predict 1-, 3-, and 5-year survival rates. (H) By drawing a line graph, we predicted the OS period over a time range of 1-, 3-, and 5-year. Each risk factor corresponds to a point axis by drawing a line on the graph. *, P<0.05; **, P<0.01; ***, P<0.001. AUC, area under the curve; CI, confidence interval; G, grade; H, high; HR, hazard ratio; KIRC, kidney renal clear cell carcinoma; L, low; OS, overall survival; ROC, receiver operating characteristic; T, tumor.
Ubch5c Ube2d3, supplied by R&D Systems, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 92 stars, based on 1 article reviews
ubch5c ube2d3 - by Bioz Stars, 2026-04
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Image Search Results


Copper metabolism related genes DLD and UBE2D3 act as protective factors in KIRC. (A) The OS Kaplan-Meier curve of DLD genes. (B) The ROC curve of DLD gene. (C) The Kaplan-Meier curve (OS) of UBE2D3 gene. The ROC curve of UBE2D3 gene (D) shows the differential expression of UBE2D3 gene at different T stages (E). (F) The expression differences of gene UBE2D3 in different G stages. (G) The calibration curve of the Norman plot is used to predict 1-, 3-, and 5-year survival rates. (H) By drawing a line graph, we predicted the OS period over a time range of 1-, 3-, and 5-year. Each risk factor corresponds to a point axis by drawing a line on the graph. *, P<0.05; **, P<0.01; ***, P<0.001. AUC, area under the curve; CI, confidence interval; G, grade; H, high; HR, hazard ratio; KIRC, kidney renal clear cell carcinoma; L, low; OS, overall survival; ROC, receiver operating characteristic; T, tumor.

Journal: Translational Andrology and Urology

Article Title: Systematic analysis of UBE2D3 and its association with prognosis, tumor microenvironment, and drug sensitivity in renal clear cell carcinoma

doi: 10.21037/tau-2025-427

Figure Lengend Snippet: Copper metabolism related genes DLD and UBE2D3 act as protective factors in KIRC. (A) The OS Kaplan-Meier curve of DLD genes. (B) The ROC curve of DLD gene. (C) The Kaplan-Meier curve (OS) of UBE2D3 gene. The ROC curve of UBE2D3 gene (D) shows the differential expression of UBE2D3 gene at different T stages (E). (F) The expression differences of gene UBE2D3 in different G stages. (G) The calibration curve of the Norman plot is used to predict 1-, 3-, and 5-year survival rates. (H) By drawing a line graph, we predicted the OS period over a time range of 1-, 3-, and 5-year. Each risk factor corresponds to a point axis by drawing a line on the graph. *, P<0.05; **, P<0.01; ***, P<0.001. AUC, area under the curve; CI, confidence interval; G, grade; H, high; HR, hazard ratio; KIRC, kidney renal clear cell carcinoma; L, low; OS, overall survival; ROC, receiver operating characteristic; T, tumor.

Article Snippet: The paraffin-embedded tissue sections were deparaffinized overnight at 4 °C with rabbit anti UBE2D3 (15475-1-AP, Protein, (15475-1-AP, Proteintech, Wuhan, China) at a dilution ratio of 1:400.

Techniques: Quantitative Proteomics, Expressing

UBE2D3 functional analysis. (A) UBE2D3 gene expression risk prognostic model. (B) UBE2D3 protein interaction network diagram. (C) Volcano plot based on UBE2D3. (D) GO analysis of differential genes between high and low UBE2D3 groups. (E) KEGG enrichment analysis between high and low UBE2D3 groups. (F) GSEA signal pathway enrichment analysis based on UBE2D3 expression. BP, biological process; CC, cellular component; ES, Enrichment Score; GO, Gene Ontology; GSEA, Gene Set Enrichment Analysis; KEGG, Kyoto Encyclopedia of Genes and Genomes; MF, molecular function; NP, nominal P value.

Journal: Translational Andrology and Urology

Article Title: Systematic analysis of UBE2D3 and its association with prognosis, tumor microenvironment, and drug sensitivity in renal clear cell carcinoma

doi: 10.21037/tau-2025-427

Figure Lengend Snippet: UBE2D3 functional analysis. (A) UBE2D3 gene expression risk prognostic model. (B) UBE2D3 protein interaction network diagram. (C) Volcano plot based on UBE2D3. (D) GO analysis of differential genes between high and low UBE2D3 groups. (E) KEGG enrichment analysis between high and low UBE2D3 groups. (F) GSEA signal pathway enrichment analysis based on UBE2D3 expression. BP, biological process; CC, cellular component; ES, Enrichment Score; GO, Gene Ontology; GSEA, Gene Set Enrichment Analysis; KEGG, Kyoto Encyclopedia of Genes and Genomes; MF, molecular function; NP, nominal P value.

Article Snippet: The paraffin-embedded tissue sections were deparaffinized overnight at 4 °C with rabbit anti UBE2D3 (15475-1-AP, Protein, (15475-1-AP, Proteintech, Wuhan, China) at a dilution ratio of 1:400.

Techniques: Functional Assay, Gene Expression, Expressing

Correlation analysis between UBE2D3 expression and immune cells. (A) Using CIBERSORT method to explore the differences in expression levels of 22 immune cells at different levels of UBE2D3. (B) Correlation analysis between 22 different immune cells. (C) Correlation analysis between UBE2D3 expression levels and biological markers between B cell, Th cell, CD8 + T cell, and DC. (D) Correlation analysis between UBE2D3 expression levels and biological markers between M2 macrophages. (E) Correlation analysis between UBE2D3 expression levels and biological markers between CAF, MDSC, and TAM. (F) Expression of UBE2D3 Correlation analysis chart between levels and biological markers of T exhausted cell, Treg T cell, and macrophages. *, P<0.05; **, P<0.01; ***, P<0.001; ****, P<0.0001. CAF, cancer-associated fibroblast; CIBERSORT, Cell-Identification By Estimating Relative Subsets Of RNA Transcripts; MDSC, myeloid-derived suppressor cells; TAM, tumor-associated macrophages.

Journal: Translational Andrology and Urology

Article Title: Systematic analysis of UBE2D3 and its association with prognosis, tumor microenvironment, and drug sensitivity in renal clear cell carcinoma

doi: 10.21037/tau-2025-427

Figure Lengend Snippet: Correlation analysis between UBE2D3 expression and immune cells. (A) Using CIBERSORT method to explore the differences in expression levels of 22 immune cells at different levels of UBE2D3. (B) Correlation analysis between 22 different immune cells. (C) Correlation analysis between UBE2D3 expression levels and biological markers between B cell, Th cell, CD8 + T cell, and DC. (D) Correlation analysis between UBE2D3 expression levels and biological markers between M2 macrophages. (E) Correlation analysis between UBE2D3 expression levels and biological markers between CAF, MDSC, and TAM. (F) Expression of UBE2D3 Correlation analysis chart between levels and biological markers of T exhausted cell, Treg T cell, and macrophages. *, P<0.05; **, P<0.01; ***, P<0.001; ****, P<0.0001. CAF, cancer-associated fibroblast; CIBERSORT, Cell-Identification By Estimating Relative Subsets Of RNA Transcripts; MDSC, myeloid-derived suppressor cells; TAM, tumor-associated macrophages.

Article Snippet: The paraffin-embedded tissue sections were deparaffinized overnight at 4 °C with rabbit anti UBE2D3 (15475-1-AP, Protein, (15475-1-AP, Proteintech, Wuhan, China) at a dilution ratio of 1:400.

Techniques: Expressing, Derivative Assay

UBE2D3 affects the tumor immune microenvironment. (A) Using TIMER database to evaluate the correlation between UBE2D3 and immune cells. (B) Box plot shows the distribution of each immune subgroup in KIRC at each copy number state, comparing the infiltration levels of each SCNA category with normal levels. *, P<0.05; **, P<0.01; ***, P<0.001; ****, P<0.0001. KIRC, kidney renal clear cell carcinoma; SCNA, Somatic Copy-number Alteration; TCGA, The Cancer Genome Atlas; TIMER, Tumor Immune Estimation Resource.

Journal: Translational Andrology and Urology

Article Title: Systematic analysis of UBE2D3 and its association with prognosis, tumor microenvironment, and drug sensitivity in renal clear cell carcinoma

doi: 10.21037/tau-2025-427

Figure Lengend Snippet: UBE2D3 affects the tumor immune microenvironment. (A) Using TIMER database to evaluate the correlation between UBE2D3 and immune cells. (B) Box plot shows the distribution of each immune subgroup in KIRC at each copy number state, comparing the infiltration levels of each SCNA category with normal levels. *, P<0.05; **, P<0.01; ***, P<0.001; ****, P<0.0001. KIRC, kidney renal clear cell carcinoma; SCNA, Somatic Copy-number Alteration; TCGA, The Cancer Genome Atlas; TIMER, Tumor Immune Estimation Resource.

Article Snippet: The paraffin-embedded tissue sections were deparaffinized overnight at 4 °C with rabbit anti UBE2D3 (15475-1-AP, Protein, (15475-1-AP, Proteintech, Wuhan, China) at a dilution ratio of 1:400.

Techniques:

Expression and infiltration of UBE2D3 among different cell populations in the single-cell sequencing dataset. (A) The expression of UBE2D3 in different cells in different datasets. (B) The distribution of GSE139555 cells in the scRNA seq dataset. (C) The distribution of 11 annotation groups in the scRNA seq dataset. (D) The distribution of UBE2D3 in different cells in the scRNA seq dataset. (E) The expression differences of UBE2D3 in different cells between KIRC patients and normal individuals. (F) The expression differences of UBE2D3 in different tumor stages and cells. GSE, GEO Series Accession Number; KIRC, kidney renal clear cell carcinoma; N.S., not significant; NAT, normal adjacent tissue; PBMC, peripheral blood mononuclear cells; scRNA seq, single-cell RNA sequencing; TNM, tumor-node-metastasis; TPM, transcripts per million.

Journal: Translational Andrology and Urology

Article Title: Systematic analysis of UBE2D3 and its association with prognosis, tumor microenvironment, and drug sensitivity in renal clear cell carcinoma

doi: 10.21037/tau-2025-427

Figure Lengend Snippet: Expression and infiltration of UBE2D3 among different cell populations in the single-cell sequencing dataset. (A) The expression of UBE2D3 in different cells in different datasets. (B) The distribution of GSE139555 cells in the scRNA seq dataset. (C) The distribution of 11 annotation groups in the scRNA seq dataset. (D) The distribution of UBE2D3 in different cells in the scRNA seq dataset. (E) The expression differences of UBE2D3 in different cells between KIRC patients and normal individuals. (F) The expression differences of UBE2D3 in different tumor stages and cells. GSE, GEO Series Accession Number; KIRC, kidney renal clear cell carcinoma; N.S., not significant; NAT, normal adjacent tissue; PBMC, peripheral blood mononuclear cells; scRNA seq, single-cell RNA sequencing; TNM, tumor-node-metastasis; TPM, transcripts per million.

Article Snippet: The paraffin-embedded tissue sections were deparaffinized overnight at 4 °C with rabbit anti UBE2D3 (15475-1-AP, Protein, (15475-1-AP, Proteintech, Wuhan, China) at a dilution ratio of 1:400.

Techniques: Expressing, Single Cell, Sequencing, RNA Sequencing

UBE2D3 mutation and methylation analysis. (A) Methylation level analysis of UBE2D3 between tumor and normal groups. (B) Methylation level analysis of UBE2D3 in normal group and different stage. (C) Methylation level analysis of UBE2D3 in normal group and different grade stages. (D) Methylation level analysis of UBE2D3 in normal group and different N-stage. (E) Heat map analysis of DNA methylation in the MethSurv database. (F) Correlation between CNV and expression level of UBE2D3. (G) Correlation between CNV level of UBE2D3 and survival. *, P<0.05; **, P<0.01; ***, P<0.001. CNV, copy number variation; Cor, correlation; DFI, disease-free interval; DSS, disease-specific survival; FDR, false discovery rate; KIRC, kidney renal clear cell carcinoma; mRNA, messenger RNA; N, node; OS, overall survival; PFS, progression-free survival; RSEM, RNA-seq by expectation-maximization; TCGA, The Cancer Genome Atlas.

Journal: Translational Andrology and Urology

Article Title: Systematic analysis of UBE2D3 and its association with prognosis, tumor microenvironment, and drug sensitivity in renal clear cell carcinoma

doi: 10.21037/tau-2025-427

Figure Lengend Snippet: UBE2D3 mutation and methylation analysis. (A) Methylation level analysis of UBE2D3 between tumor and normal groups. (B) Methylation level analysis of UBE2D3 in normal group and different stage. (C) Methylation level analysis of UBE2D3 in normal group and different grade stages. (D) Methylation level analysis of UBE2D3 in normal group and different N-stage. (E) Heat map analysis of DNA methylation in the MethSurv database. (F) Correlation between CNV and expression level of UBE2D3. (G) Correlation between CNV level of UBE2D3 and survival. *, P<0.05; **, P<0.01; ***, P<0.001. CNV, copy number variation; Cor, correlation; DFI, disease-free interval; DSS, disease-specific survival; FDR, false discovery rate; KIRC, kidney renal clear cell carcinoma; mRNA, messenger RNA; N, node; OS, overall survival; PFS, progression-free survival; RSEM, RNA-seq by expectation-maximization; TCGA, The Cancer Genome Atlas.

Article Snippet: The paraffin-embedded tissue sections were deparaffinized overnight at 4 °C with rabbit anti UBE2D3 (15475-1-AP, Protein, (15475-1-AP, Proteintech, Wuhan, China) at a dilution ratio of 1:400.

Techniques: Mutagenesis, Methylation, DNA Methylation Assay, Expressing, RNA Sequencing

Analyze the drug sensitivity of UBE2D3 in KIRC and predict the IC 50 of the drug. (A) Vincristine. (B) Bosutinib. (C) Ambazone. (D) Finefloxacin. (E) Anagrelide. (F) Meclizine. (G) Dabrafenib. (H) Navitoclax. (I) Propranolol. ***, P<0.001. IC 50 , median inhibitory concentration; KIRC, kidney renal clear cell carcinoma.

Journal: Translational Andrology and Urology

Article Title: Systematic analysis of UBE2D3 and its association with prognosis, tumor microenvironment, and drug sensitivity in renal clear cell carcinoma

doi: 10.21037/tau-2025-427

Figure Lengend Snippet: Analyze the drug sensitivity of UBE2D3 in KIRC and predict the IC 50 of the drug. (A) Vincristine. (B) Bosutinib. (C) Ambazone. (D) Finefloxacin. (E) Anagrelide. (F) Meclizine. (G) Dabrafenib. (H) Navitoclax. (I) Propranolol. ***, P<0.001. IC 50 , median inhibitory concentration; KIRC, kidney renal clear cell carcinoma.

Article Snippet: The paraffin-embedded tissue sections were deparaffinized overnight at 4 °C with rabbit anti UBE2D3 (15475-1-AP, Protein, (15475-1-AP, Proteintech, Wuhan, China) at a dilution ratio of 1:400.

Techniques: Concentration Assay

Molecular docking patterns of key drugs and core targets. (A) Vincristine binding to P113 isosite. (B) Bosutinib binding to S100 isosite. (C) Ambazone binding to L89 isosite. (D) Finefloxacin binding to P95 isosite. (E) Anagrelide binding to T98 isosite. (F) Meclizine binding to P57 isosite. (G) Dabrafenib binding to K63 isosite. (H) Navitoclax binding to A68 isosite. (I) Propanol binding to E9 isosite. (J) Different small molecule drugs binding to target UBE2D3 Vina score comparison.

Journal: Translational Andrology and Urology

Article Title: Systematic analysis of UBE2D3 and its association with prognosis, tumor microenvironment, and drug sensitivity in renal clear cell carcinoma

doi: 10.21037/tau-2025-427

Figure Lengend Snippet: Molecular docking patterns of key drugs and core targets. (A) Vincristine binding to P113 isosite. (B) Bosutinib binding to S100 isosite. (C) Ambazone binding to L89 isosite. (D) Finefloxacin binding to P95 isosite. (E) Anagrelide binding to T98 isosite. (F) Meclizine binding to P57 isosite. (G) Dabrafenib binding to K63 isosite. (H) Navitoclax binding to A68 isosite. (I) Propanol binding to E9 isosite. (J) Different small molecule drugs binding to target UBE2D3 Vina score comparison.

Article Snippet: The paraffin-embedded tissue sections were deparaffinized overnight at 4 °C with rabbit anti UBE2D3 (15475-1-AP, Protein, (15475-1-AP, Proteintech, Wuhan, China) at a dilution ratio of 1:400.

Techniques: Binding Assay, Comparison

Immunostaining image of UBE2D3 . (A) Expression of UBE2D3 in Para cancer (100×). (B) Expression of UBE2D3 in Para cancer (200×). (C) Expression of UBE2D3 in KIRC (100×). (D) Expression of UBE2D3 in KIRC (200×). (E) IHC staining statistics of UBE2D3 in KIRC and adjacent tissues. **, P<0.01. AOD, average optical density; IHC, immunohistochemistry; KIRC, kidney renal clear cell carcinoma.

Journal: Translational Andrology and Urology

Article Title: Systematic analysis of UBE2D3 and its association with prognosis, tumor microenvironment, and drug sensitivity in renal clear cell carcinoma

doi: 10.21037/tau-2025-427

Figure Lengend Snippet: Immunostaining image of UBE2D3 . (A) Expression of UBE2D3 in Para cancer (100×). (B) Expression of UBE2D3 in Para cancer (200×). (C) Expression of UBE2D3 in KIRC (100×). (D) Expression of UBE2D3 in KIRC (200×). (E) IHC staining statistics of UBE2D3 in KIRC and adjacent tissues. **, P<0.01. AOD, average optical density; IHC, immunohistochemistry; KIRC, kidney renal clear cell carcinoma.

Article Snippet: The paraffin-embedded tissue sections were deparaffinized overnight at 4 °C with rabbit anti UBE2D3 (15475-1-AP, Protein, (15475-1-AP, Proteintech, Wuhan, China) at a dilution ratio of 1:400.

Techniques: Immunostaining, Expressing, Immunohistochemistry