Journal: Pharmaceutics

Article Title: Neuroprotective Activity of a Non-Covalent Imatinib+TP10 Conjugate in HT-22 Neuronal Cells In Vitro

doi: 10.3390/pharmaceutics16060778

Figure Lengend Snippet: The effect of the Im (imatinib)+PEG 4 +TP10 and Im+PEG 4 +TAT mixtures and their constituents on the MPP + -induced oxidative stress. * Statistically significant ( p < 0.05) as compared to the control.

Article Snippet: The compounds, i.e., TP10 (AGYLLGKINLKALAALAKKIL-NH2) and TAT (GRKKRRQRRRPQ-NH2), were synthetized to an individual order by Pepmic Co., Ltd. (Beijing, China).

Techniques: Control

Journal: Pharmaceutics

Article Title: Neuroprotective Activity of a Non-Covalent Imatinib+TP10 Conjugate in HT-22 Neuronal Cells In Vitro

doi: 10.3390/pharmaceutics16060778

Figure Lengend Snippet: Sequentially repeated measurements of luminescence ( A1 – A5 ) and fluorescence ( B1 – B5 ) in MPP + treated HT-22 cells after administration of the following: ( A1 , B1 ) TP10; ( A2 , B2 ) PEG 4 ; ( A3 , B3 ) Im; ( A4 , B4 ) Im+TP10; and ( A5 , B5 ) Im+PEG 4 +TP10. * Statistically significant ( p < 0.05) as compared to the control.

Article Snippet: The compounds, i.e., TP10 (AGYLLGKINLKALAALAKKIL-NH2) and TAT (GRKKRRQRRRPQ-NH2), were synthetized to an individual order by Pepmic Co., Ltd. (Beijing, China).

Techniques: Fluorescence, Control

Journal: Pharmaceutics

Article Title: Neuroprotective Activity of a Non-Covalent Imatinib+TP10 Conjugate in HT-22 Neuronal Cells In Vitro

doi: 10.3390/pharmaceutics16060778

Figure Lengend Snippet: HT-22 cell viability of the following: ( A ) control; ( B ) MPP + ; ( C ) MPP + +Im; and ( D ) MPP + +Im+PEG 4 +TP10, visible using fluorescence microscopy (×60 objective).

Article Snippet: The compounds, i.e., TP10 (AGYLLGKINLKALAALAKKIL-NH2) and TAT (GRKKRRQRRRPQ-NH2), were synthetized to an individual order by Pepmic Co., Ltd. (Beijing, China).

Techniques: Control, Fluorescence, Microscopy

Journal: Pharmaceutics

Article Title: Neuroprotective Activity of a Non-Covalent Imatinib+TP10 Conjugate in HT-22 Neuronal Cells In Vitro

doi: 10.3390/pharmaceutics16060778

Figure Lengend Snippet: The impact of Im, TP10, and Im+PEG 4 +TP10 on the ABCB1 (170 kDa) protein in MPP + treated HT-22 cell lysates. An actin band of 42 kDa was used as a loading control.

Article Snippet: The compounds, i.e., TP10 (AGYLLGKINLKALAALAKKIL-NH2) and TAT (GRKKRRQRRRPQ-NH2), were synthetized to an individual order by Pepmic Co., Ltd. (Beijing, China).

Techniques: Control

Journal: Pharmaceutics

Article Title: Neuroprotective Activity of a Non-Covalent Imatinib+TP10 Conjugate in HT-22 Neuronal Cells In Vitro

doi: 10.3390/pharmaceutics16060778

Figure Lengend Snippet: The impact of Im, TP10, and Im+PEG 4 +TP10 on HT-22 cell viability. * Statistically significant ( p < 0.05) as compared to the control.

Article Snippet: The compounds, i.e., TP10 (AGYLLGKINLKALAALAKKIL-NH2) and TAT (GRKKRRQRRRPQ-NH2), were synthetized to an individual order by Pepmic Co., Ltd. (Beijing, China).

Techniques: Control

Journal: Pharmaceutics

Article Title: Neuroprotective Activity of a Non-Covalent Imatinib+TP10 Conjugate in HT-22 Neuronal Cells In Vitro

doi: 10.3390/pharmaceutics16060778

Figure Lengend Snippet: The IC50 values of ( a ) Im; ( b ) TP10; and ( c ) Im+PEG 4 +TP10, calculated by the non-linear four-parametric method.

Article Snippet: The compounds, i.e., TP10 (AGYLLGKINLKALAALAKKIL-NH2) and TAT (GRKKRRQRRRPQ-NH2), were synthetized to an individual order by Pepmic Co., Ltd. (Beijing, China).

Techniques:

Journal: Pharmaceutics

Article Title: Neuroprotective Activity of a Non-Covalent Imatinib+TP10 Conjugate in HT-22 Neuronal Cells In Vitro

doi: 10.3390/pharmaceutics16060778

Figure Lengend Snippet: The cytotoxic effect of TP10, PEG 4 , Im, Im+TP10, and Im+PEG 4 +TP10 on HT-22 cells. * Statistically significant ( p < 0.05) as compared to the control.

Article Snippet: The compounds, i.e., TP10 (AGYLLGKINLKALAALAKKIL-NH2) and TAT (GRKKRRQRRRPQ-NH2), were synthetized to an individual order by Pepmic Co., Ltd. (Beijing, China).

Techniques: Control