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Med Associates Inc
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Chem Impex International
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TargetMol
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Chem Impex International
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Chem Impex International
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Paulmann Licht GmbH
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SHOEBOX Inc
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Amplivox Ltd
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Coulbourn Instruments
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Wavetek Inc
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Allresist GmbH
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MAICO Diagnostics GmbH
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Image Search Results
Journal: Journal of Cancer Research and Clinical Oncology
Article Title: E3 ubiquitin ligase BTRC inhibits the proliferation and tumor growth of glioma cells through the NFAT5/AQP4 axis
doi: 10.1007/s00432-025-06346-z
Figure Lengend Snippet: BTRC interacts with NFAT5 to influence its ubiquitination level. A Ubiquitination regulation relationship between NFAT5 and BTRC was performed by the UbiBrowser database. B Co-IP was used to verify the combination of BTRC and NFAT5. C The protein level of NFAT5 was detected using WB. D The protein level of NFAT5 was detected using WB. E The ubiquitination level of NFAT5 was detected by the IP experiment. n = 3. One-way or two-way ANOVA was used to analyze the differences among the groups, followed by Tukey's multiple comparisons test. ** indicates p < 0.01, *** indicates p < 0.001 compared with the oe-NC or oe-BTRC group
Article Snippet: To investigate the regulatory relationship between BTRC and
Techniques: Ubiquitin Proteomics, Co-Immunoprecipitation Assay
Journal: Journal of Cancer Research and Clinical Oncology
Article Title: E3 ubiquitin ligase BTRC inhibits the proliferation and tumor growth of glioma cells through the NFAT5/AQP4 axis
doi: 10.1007/s00432-025-06346-z
Figure Lengend Snippet: NFAT5 mediates the transcription of AQP4 affecting its expression in glioma Cells. A AnimalTFDB v4.0 was used to predict the binding sites of NFAT5 on the promoter region of AQP4, and the binding of NFAT5 and the AQP4 promoter region was detected by CHIP assay. B NFAT5 expression was detected by WB. C AQP4 expression was detected by RT-qPCR and WB. n = 3. A t-test or two-way ANOVA was used to analyze the differences between each group, followed by Tukey's multiple comparisons test. * indicates p < 0.05, *** indicates p < 0.001 compared with the IgG or si-NC group
Article Snippet: To investigate the regulatory relationship between BTRC and
Techniques: Expressing, Binding Assay, Quantitative RT-PCR
Journal: Journal of Cancer Research and Clinical Oncology
Article Title: E3 ubiquitin ligase BTRC inhibits the proliferation and tumor growth of glioma cells through the NFAT5/AQP4 axis
doi: 10.1007/s00432-025-06346-z
Figure Lengend Snippet: BTRC influences the malignant behavior of glioma cells through the NFAT5/AQP4 Axis. A The expressions of BTRC, NFAT5 and AQP4 were detected by WB. B Cell viability was detected by CCK8. C The apoptosis level was detected by flow cytometry. D Cell migration was detected by scratch assays. E Transwell was used to detect cell invasion. n = 3. A two-way ANOVA was used to analyze the differences among the groups, followed by a Tukey's multiple comparisons test. NS indicates p > 0.05, ** indicates p < 0.01, *** indicates p < 0.001 compared with the NC or oe-BTRC group
Article Snippet: To investigate the regulatory relationship between BTRC and
Techniques: Flow Cytometry, Migration
Journal: Journal of Cancer Research and Clinical Oncology
Article Title: E3 ubiquitin ligase BTRC inhibits the proliferation and tumor growth of glioma cells through the NFAT5/AQP4 axis
doi: 10.1007/s00432-025-06346-z
Figure Lengend Snippet: In vivo validation of BTRC's effect on glioma xenograft growth through the NFAT5/AQP4 axis. A Tumor images. B Tumor volume curve. C Tumor weight. D IHC was used to detect the positive rate of Ki67 in the tumor. E WB detection of BTRC, NFAT5, and AQP4 expression. n = 5. Differences among groups were analyzed using one-way or two-way ANOVA, followed by Tukey's multiple comparisons test. NS indicates p > 0.05, * indicates p < 0.05, *** indicates p < 0.001 compared with the NC or oe-BTRC group
Article Snippet: To investigate the regulatory relationship between BTRC and
Techniques: In Vivo, Biomarker Discovery, Expressing