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Image Search Results
Journal: CNS neuroscience & therapeutics
Article Title: Asparagine Endopeptidase Inhibition Attenuates Tissue Plasminogen Activator-Induced Brain Hemorrhagic Transformation After Ischemic Stroke.
doi: 10.1111/cns.70345
Figure Lengend Snippet: FIGURE 3 | AEP KO ameliorates tPA-associated hemorrhagic transformation in the stroke mouse model. (A, B) Representative images of hema- toma in brain slices and quantification of hemoglobin levels. Data are presented as mean ± SEM and statistical analyses are performed using Welch test followed by Dunnett T3 multiple comparisons test were applied since the P value of Levene test < 0.05. (C) Recorded brain water content to as- sess brain edema at 24 h after delayed tPA administration. Data are presented as mean ± SEM and statistical analysis is performed using one-way ANOVA test followed by Tukey's multiple comparisons test. (D) ELISA for tPA activity detection. Data are presented as mean ± SEM and statistical analyses are performed using Welch test followed by Dunnett T3 multiple comparisons test were applied since the P value of Levene test < 0.05. (E) Representative images of HE staining in the cortical hematoma area (scale bar = 50 μm). (A), (C) n = 6, (D) n = 4 per group. Normality and variance are assessed via Shapiro-Wilk test and Levene's test, respectively. *P < 0.05, **P < 0.01.
Article Snippet: A
Techniques: Transformation Assay, Enzyme-linked Immunosorbent Assay, Activity Assay, Staining
Journal: Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Article Title: Impact of β-Adrenoceptor Blockade on Systemic Inflammation and Coagulation Disturbances in Rats with Acute Traumatic Coagulopathy
doi: 10.12659/MSM.893544
Figure Lengend Snippet: Effects of propranolol on concentrations of ( A ) D-dimer, ( B ) plasmin anti-plasmin (PAP) complex, ( C ) tissue type plasminogen activator (tPA), and ( D ) plasminogen activator inhibitor 1 (PAI-1) in serum. SHAM (sham group), ATCC (ATC control group), ATCB (propranolol-treated ATC model group). Values are expressed as mean ±SD. * P <0.01, ATCC vs. ATCB; & P <0.01, ATCC vs. SHAM group; # P <0.01, SHAM vs. ATCB.
Article Snippet: The following markers were detected by enzyme-linked immunosorbent assay (ELISA) according to the manufacturers’ instructions: soluble thrombomodulin (sTM) (Cusabio Biotech, Wuhan, CHN), TNF-α (R&D Systems, Minneapolis, MN), IL-6 (R&D Systems, Minneapolis, MN), thrombin anti-thrombin (TAT) (Diagnostica Stago, Roche, Almere, NL), activated protein C (aPC) (SANGON Biological Engineering, Shanghai, CHN), plasmin-antiplasmin complex (PAP) (Cusabio Biotech, Wuhan, CHN), D-dimer (USCN Life Science, Wuhan, CHN),
Techniques: Control