targeting peptide c Search Results


α5β1 integrin targeting peptide c(rretawa  (AAPPTec Inc)
90
AAPPTec Inc α5β1 integrin targeting peptide c(rretawa
Design and characterization of MAP hydrogels with varying degradability. a) A schematic of MAP hydrogels assembled from off-stoichiometric PEG microgels via a secondary thiol-ene photopolymerization. b) Peptide sequences designed as crosslinkers and cell-adhesive ligands to achieve varying degradability and <t>integrin</t> binding. c) A representative Z-stack projection image of MAP hydrogels labeled with Alexa Fluor 488- succinimidyl ester illustrating the internal porous structure. Scale bar is 100 μm. d) Degradation curves of non-deg, slow-deg and fast-deg MAP hydrogels in a 0.2 mg/mL collagenase solution at 37 °C. e) Storage modulus of slow-deg and fast deg MAP hydrogels after degradation with 0%, 33%, and 67% mass loss.
α5β1 Integrin Targeting Peptide C(rretawa, supplied by AAPPTec Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/targeting+peptide+c/pmc06960331-134-1-9?v=AAPPTec+Inc
Average 90 stars, based on 1 article reviews
α5β1 integrin targeting peptide c(rretawa - by Bioz Stars, 2026-07
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Design and characterization of MAP hydrogels with varying degradability. a) A schematic of MAP hydrogels assembled from off-stoichiometric PEG microgels via a secondary thiol-ene photopolymerization. b) Peptide sequences designed as crosslinkers and cell-adhesive ligands to achieve varying degradability and integrin binding. c) A representative Z-stack projection image of MAP hydrogels labeled with Alexa Fluor 488- succinimidyl ester illustrating the internal porous structure. Scale bar is 100 μm. d) Degradation curves of non-deg, slow-deg and fast-deg MAP hydrogels in a 0.2 mg/mL collagenase solution at 37 °C. e) Storage modulus of slow-deg and fast deg MAP hydrogels after degradation with 0%, 33%, and 67% mass loss.

Journal: Acta biomaterialia

Article Title: Interplay Between Degradability and Integrin Signaling on Mesenchymal Stem Cell Function within Poly(ethylene glycol) Based Microporous Annealed Particle Hydrogels

doi: 10.1016/j.actbio.2019.11.009

Figure Lengend Snippet: Design and characterization of MAP hydrogels with varying degradability. a) A schematic of MAP hydrogels assembled from off-stoichiometric PEG microgels via a secondary thiol-ene photopolymerization. b) Peptide sequences designed as crosslinkers and cell-adhesive ligands to achieve varying degradability and integrin binding. c) A representative Z-stack projection image of MAP hydrogels labeled with Alexa Fluor 488- succinimidyl ester illustrating the internal porous structure. Scale bar is 100 μm. d) Degradation curves of non-deg, slow-deg and fast-deg MAP hydrogels in a 0.2 mg/mL collagenase solution at 37 °C. e) Storage modulus of slow-deg and fast deg MAP hydrogels after degradation with 0%, 33%, and 67% mass loss.

Article Snippet: The α5β1 integrin targeting peptide c(RRETAWA) was purchased from AAPPtec and was synthesized via an on-resin cyclization reaction of Ac-CAhxK(Alloc)RRETAWAE(ODmab), as previously described by Gandavarapu et al. [ 30 ].

Techniques: Binding Assay, Labeling

The effect of degradability on hMSC spreading and proliferation in c(RRETAWA)-functionalized MAP hydrogels. a) Maximum intensity Z- projection of cytoskeleton staining of hMSCs cultured in MAP hydrogels after 2 and 8 days. Green represents F- actin and blue represents nuclei. Scale bars are 100 μm. b) Quantification of cell number. c) Quantification of cell volume. * comparison factor: degradability; # comparison factor: time. ** indicates p < 0.01, *** and ### indicate p < 0.0001, Two-way ANOVA and Tukey’s multiple comparisons test.

Journal: Acta biomaterialia

Article Title: Interplay Between Degradability and Integrin Signaling on Mesenchymal Stem Cell Function within Poly(ethylene glycol) Based Microporous Annealed Particle Hydrogels

doi: 10.1016/j.actbio.2019.11.009

Figure Lengend Snippet: The effect of degradability on hMSC spreading and proliferation in c(RRETAWA)-functionalized MAP hydrogels. a) Maximum intensity Z- projection of cytoskeleton staining of hMSCs cultured in MAP hydrogels after 2 and 8 days. Green represents F- actin and blue represents nuclei. Scale bars are 100 μm. b) Quantification of cell number. c) Quantification of cell volume. * comparison factor: degradability; # comparison factor: time. ** indicates p < 0.01, *** and ### indicate p < 0.0001, Two-way ANOVA and Tukey’s multiple comparisons test.

Article Snippet: The α5β1 integrin targeting peptide c(RRETAWA) was purchased from AAPPtec and was synthesized via an on-resin cyclization reaction of Ac-CAhxK(Alloc)RRETAWAE(ODmab), as previously described by Gandavarapu et al. [ 30 ].

Techniques: Staining, Cell Culture

ECM proteins, collagen type I and fibronectin synthesized by hMSCs in MAP hydrogels with varying degradability and integrin-binding peptides after 8 days of culture. a) Z-projection images from confocal microscopy. Scale bars are 100 μm. b) Quantification of total ECM protein per 50 μL MAP hydrogels. * comparison factor: degradability; # comparison factor: integrin-binding peptide. * indicates p < 0.05, *** and ### indicate p < 0.0001, Two-way ANOVA by Tukey’s multiple comparisons test.

Journal: Acta biomaterialia

Article Title: Interplay Between Degradability and Integrin Signaling on Mesenchymal Stem Cell Function within Poly(ethylene glycol) Based Microporous Annealed Particle Hydrogels

doi: 10.1016/j.actbio.2019.11.009

Figure Lengend Snippet: ECM proteins, collagen type I and fibronectin synthesized by hMSCs in MAP hydrogels with varying degradability and integrin-binding peptides after 8 days of culture. a) Z-projection images from confocal microscopy. Scale bars are 100 μm. b) Quantification of total ECM protein per 50 μL MAP hydrogels. * comparison factor: degradability; # comparison factor: integrin-binding peptide. * indicates p < 0.05, *** and ### indicate p < 0.0001, Two-way ANOVA by Tukey’s multiple comparisons test.

Article Snippet: The α5β1 integrin targeting peptide c(RRETAWA) was purchased from AAPPtec and was synthesized via an on-resin cyclization reaction of Ac-CAhxK(Alloc)RRETAWAE(ODmab), as previously described by Gandavarapu et al. [ 30 ].

Techniques: Synthesized, Binding Assay, Confocal Microscopy

hMSC expression of OPG in RGDS and c(RRETAWA)-functionalized MAP hydrogels with varying degradability after 2, 5, and 8 days of culture. Three-way ANOVA results: time (p < 0.0001), time×degradability (p < 0.0001), integrin-binding peptide×degradability (p < 0.05).

Journal: Acta biomaterialia

Article Title: Interplay Between Degradability and Integrin Signaling on Mesenchymal Stem Cell Function within Poly(ethylene glycol) Based Microporous Annealed Particle Hydrogels

doi: 10.1016/j.actbio.2019.11.009

Figure Lengend Snippet: hMSC expression of OPG in RGDS and c(RRETAWA)-functionalized MAP hydrogels with varying degradability after 2, 5, and 8 days of culture. Three-way ANOVA results: time (p < 0.0001), time×degradability (p < 0.0001), integrin-binding peptide×degradability (p < 0.05).

Article Snippet: The α5β1 integrin targeting peptide c(RRETAWA) was purchased from AAPPtec and was synthesized via an on-resin cyclization reaction of Ac-CAhxK(Alloc)RRETAWAE(ODmab), as previously described by Gandavarapu et al. [ 30 ].

Techniques: Expressing, Binding Assay

hMSC secretion of a, b) VEGF and c, d) BMP2 in MAP hydrogels functionalized with RGDS and c(RRETAWA) and with varying degradability after 8 days of culture. Data presented are both before and after normalization. * comparison factor: degradability; # comparison factor: integrin-binding peptide. * and # indicate p < 0.05, ## indicates p < 0.01, *** indicates p < 0.0001, Two-way ANOVA by Tukey’s multiple comparisons test.

Journal: Acta biomaterialia

Article Title: Interplay Between Degradability and Integrin Signaling on Mesenchymal Stem Cell Function within Poly(ethylene glycol) Based Microporous Annealed Particle Hydrogels

doi: 10.1016/j.actbio.2019.11.009

Figure Lengend Snippet: hMSC secretion of a, b) VEGF and c, d) BMP2 in MAP hydrogels functionalized with RGDS and c(RRETAWA) and with varying degradability after 8 days of culture. Data presented are both before and after normalization. * comparison factor: degradability; # comparison factor: integrin-binding peptide. * and # indicate p < 0.05, ## indicates p < 0.01, *** indicates p < 0.0001, Two-way ANOVA by Tukey’s multiple comparisons test.

Article Snippet: The α5β1 integrin targeting peptide c(RRETAWA) was purchased from AAPPtec and was synthesized via an on-resin cyclization reaction of Ac-CAhxK(Alloc)RRETAWAE(ODmab), as previously described by Gandavarapu et al. [ 30 ].

Techniques: Binding Assay