tamibarotene Search Results


shrs  (MedChemExpress)
92
MedChemExpress shrs
Shrs, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/tamibarotene/Tamibarotene/pm36768908-187-1-10
Average 92 stars, based on 1 article reviews
shrs - by Bioz Stars, 2026-09
92/100 stars
  Buy from Supplier
tamibarotene  (TargetMol)
N/A
   Buy from Supplier
rarα synthetic agonist  (Selleck Chemicals)
92
Selleck Chemicals rarα synthetic agonist
Rarα Synthetic Agonist, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/tamibarotene/Tamibarotene/pmc06345457-24-36-46
Average 92 stars, based on 1 article reviews
rarα synthetic agonist - by Bioz Stars, 2026-09
92/100 stars
  Buy from Supplier
am80  (Santa Cruz Biotechnology)
94
Santa Cruz Biotechnology am80
Am80, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/tamibarotene/AM+80/10__1158_slash_0008___5472__can___16___3079-53-0-6
Average 94 stars, based on 1 article reviews
am80 - by Bioz Stars, 2026-09
94/100 stars
  Buy from Supplier
am80  (Tocris)
94
Tocris am80
Mutant RARα possess altered binding abilities to agonists and co-regulators. Mammalian two-hybrid assay of interactions of the wild type or mutant RARα LBD with (A) fragment of coactivator SRC2, (B) MED1, a component of the transcription pre-initiation complex and (C) fragment of corepressor NCOR, treated with increasing concentrations of RA. Left panel: Partially activatable mutants, Right panel: Non-activatable mutants. N=3, Error bar = SD. (D) Binding affinities of WT or mutant RARα LBD with fragment of coactivator SRC1 (SRC1-NR2) in the presence of RA and <t>Am80.</t> N=3, error bar = SE. **p<0.01.
Am80, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/tamibarotene/AM+80/bio_rxiv__2022__12__01__518133-140-14-17
Average 94 stars, based on 1 article reviews
am80 - by Bioz Stars, 2026-09
94/100 stars
  Buy from Supplier
tamibarotene  (Informa UK Limited)
90
Informa UK Limited tamibarotene
Mutant RARα possess altered binding abilities to agonists and co-regulators. Mammalian two-hybrid assay of interactions of the wild type or mutant RARα LBD with (A) fragment of coactivator SRC2, (B) MED1, a component of the transcription pre-initiation complex and (C) fragment of corepressor NCOR, treated with increasing concentrations of RA. Left panel: Partially activatable mutants, Right panel: Non-activatable mutants. N=3, Error bar = SD. (D) Binding affinities of WT or mutant RARα LBD with fragment of coactivator SRC1 (SRC1-NR2) in the presence of RA and <t>Am80.</t> N=3, error bar = SE. **p<0.01.
Tamibarotene, supplied by Informa UK Limited, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/tamibarotene/tamibarotene/pm37571998-13-4-19
Average 90 stars, based on 1 article reviews
tamibarotene - by Bioz Stars, 2026-09
90/100 stars
  Buy from Supplier
soft capsule tamibarotene  (Ohara Pharmaceutical)
90
Ohara Pharmaceutical soft capsule tamibarotene
Mutant RARα possess altered binding abilities to agonists and co-regulators. Mammalian two-hybrid assay of interactions of the wild type or mutant RARα LBD with (A) fragment of coactivator SRC2, (B) MED1, a component of the transcription pre-initiation complex and (C) fragment of corepressor NCOR, treated with increasing concentrations of RA. Left panel: Partially activatable mutants, Right panel: Non-activatable mutants. N=3, Error bar = SD. (D) Binding affinities of WT or mutant RARα LBD with fragment of coactivator SRC1 (SRC1-NR2) in the presence of RA and <t>Am80.</t> N=3, error bar = SE. **p<0.01.
Soft Capsule Tamibarotene, supplied by Ohara Pharmaceutical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/tamibarotene/soft+capsule+tamibarotene/pm33829292-40-11-2
Average 90 stars, based on 1 article reviews
soft capsule tamibarotene - by Bioz Stars, 2026-09
90/100 stars
  Buy from Supplier
tamibarotene  (Aladdin Scientific Corporation)
N/A
Tamibarotene is a synthetic retinoic acid receptor (RAR) agonist with high specificity for RARα and RARβ over RARγ.A RARα agonist that induces differentiation and apoptosis
   Buy from Supplier
tamibarotene  (Toronto Research Chemicals)
N/A
   Buy from Supplier
keto tamibarotene  (Toronto Research Chemicals)
N/A
   Buy from Supplier

Image Search Results


Mutant RARα possess altered binding abilities to agonists and co-regulators. Mammalian two-hybrid assay of interactions of the wild type or mutant RARα LBD with (A) fragment of coactivator SRC2, (B) MED1, a component of the transcription pre-initiation complex and (C) fragment of corepressor NCOR, treated with increasing concentrations of RA. Left panel: Partially activatable mutants, Right panel: Non-activatable mutants. N=3, Error bar = SD. (D) Binding affinities of WT or mutant RARα LBD with fragment of coactivator SRC1 (SRC1-NR2) in the presence of RA and Am80. N=3, error bar = SE. **p<0.01.

Journal: bioRxiv

Article Title: Effects of breast fibroepithelial tumor associated retinoic acid receptor alpha ligand binding domain mutations on receptor function and retinoid signaling

doi: 10.1101/2022.12.01.518133

Figure Lengend Snippet: Mutant RARα possess altered binding abilities to agonists and co-regulators. Mammalian two-hybrid assay of interactions of the wild type or mutant RARα LBD with (A) fragment of coactivator SRC2, (B) MED1, a component of the transcription pre-initiation complex and (C) fragment of corepressor NCOR, treated with increasing concentrations of RA. Left panel: Partially activatable mutants, Right panel: Non-activatable mutants. N=3, Error bar = SD. (D) Binding affinities of WT or mutant RARα LBD with fragment of coactivator SRC1 (SRC1-NR2) in the presence of RA and Am80. N=3, error bar = SE. **p<0.01.

Article Snippet: Compounds tested include all-trans retinoic acid (known as RA throughout the manuscript, Sigma R2625), Am80 (aka Tamibarotene, Tocris 3507), AM580 (Tocris 0760) and Ch55 (Tocris 2020).

Techniques: Mutagenesis, Binding Assay, Two Hybrid Assay

Sensitivity of mutant RARα to retinoid treatment. (A) Overexpression of Flag-tagged RARα WT and mutants in PT024 cells. (B) Cell viabilities of PT024 WT or mutant RARα expressing cells after treatment with increasing concentration of RA or Am80. N=3, error bar = SD. ***p<0.001, ****p<0.0001. (C) Cell cycle distribution of PT024 WT or mutant RARα expressing cells when treated with either vehicle or 100nM Am80. N=2, error bar = SD. *p<0.05, ****p < 0.0001. (D) GSEA analysis shows downregulation of retinoic acid signaling gene targets in mutant RARα-expressing cell lines. (E) Heatmap of genes associated with reactome retinoic acid signaling pathway (F) Quantitative PCR of retinoic acid signaling associated genes. N=3, error bar = SD. *p<0.05 **p<0.01 ***p<0.001 ****p < 0.0001.

Journal: bioRxiv

Article Title: Effects of breast fibroepithelial tumor associated retinoic acid receptor alpha ligand binding domain mutations on receptor function and retinoid signaling

doi: 10.1101/2022.12.01.518133

Figure Lengend Snippet: Sensitivity of mutant RARα to retinoid treatment. (A) Overexpression of Flag-tagged RARα WT and mutants in PT024 cells. (B) Cell viabilities of PT024 WT or mutant RARα expressing cells after treatment with increasing concentration of RA or Am80. N=3, error bar = SD. ***p<0.001, ****p<0.0001. (C) Cell cycle distribution of PT024 WT or mutant RARα expressing cells when treated with either vehicle or 100nM Am80. N=2, error bar = SD. *p<0.05, ****p < 0.0001. (D) GSEA analysis shows downregulation of retinoic acid signaling gene targets in mutant RARα-expressing cell lines. (E) Heatmap of genes associated with reactome retinoic acid signaling pathway (F) Quantitative PCR of retinoic acid signaling associated genes. N=3, error bar = SD. *p<0.05 **p<0.01 ***p<0.001 ****p < 0.0001.

Article Snippet: Compounds tested include all-trans retinoic acid (known as RA throughout the manuscript, Sigma R2625), Am80 (aka Tamibarotene, Tocris 3507), AM580 (Tocris 0760) and Ch55 (Tocris 2020).

Techniques: Mutagenesis, Over Expression, Expressing, Concentration Assay, Real-time Polymerase Chain Reaction