Journal: Insights into Imaging

Article Title: Multimodality imaging of neurodegenerative disorders with a focus on multiparametric magnetic resonance and molecular imaging

doi: 10.1186/s13244-022-01358-6

Figure Lengend Snippet: Commonly used radiotracers in evaluation of neurodegenerative syndromes

Article Snippet: Currently, the most widely used tau selective radiotracer is older-generation F-18 flortaucipir (Tauvid; Avid Radiopharmaceuticals, previously known as AV 1451 and T807) [ ].

Techniques: Injection, Activity Assay, Imaging, Binding Assay

Journal: Insights into Imaging

Article Title: Multimodality imaging of neurodegenerative disorders with a focus on multiparametric magnetic resonance and molecular imaging

doi: 10.1186/s13244-022-01358-6

Figure Lengend Snippet: A 73-year-old man with AD, Mini Mental State Examination (MMSE) 23/30. Fluorodeoxyglucose PET/CT ( a ) demonstrates hypometabolism involving the bilateral parietal lobes (arrows) and precuneus and PCC (oval). Flortaucipir PET/CT ( b ) shows tau retention in the bilateral parietal lobes (arrows) and precuneus and PCC (oval), mirroring the regions of hypometabolism. Florbetapir PET/CT ( c ) demonstrates diffuse cortical uptake with “kissing hemispheres.” Arterial spin labeling ( d ) demonstrates hypoperfusion to the bilateral parietal lobes (arrows), similar to the FDG-PET/CT

Article Snippet: Currently, the most widely used tau selective radiotracer is older-generation F-18 flortaucipir (Tauvid; Avid Radiopharmaceuticals, previously known as AV 1451 and T807) [ ].

Techniques: Positron Emission Tomography-Computed Tomography, Labeling

Journal: Insights into Imaging

Article Title: Multimodality imaging of neurodegenerative disorders with a focus on multiparametric magnetic resonance and molecular imaging

doi: 10.1186/s13244-022-01358-6

Figure Lengend Snippet: In vivo Braak staging on flortaucipir PET/CT. Activity confined to the entorhinal cortices and hippocampi falls into the Braak I-II stages (arrows in a ), further progression in the temporal lobes and limbic cortices classifies stages III-IV (parahippocampal gyri; arrows in b ), and neocortical activity defines stages V-VI (arrows in c )

Article Snippet: Currently, the most widely used tau selective radiotracer is older-generation F-18 flortaucipir (Tauvid; Avid Radiopharmaceuticals, previously known as AV 1451 and T807) [ ].

Techniques: In Vivo, Positron Emission Tomography-Computed Tomography, Activity Assay

Journal: Insights into Imaging

Article Title: Multimodality imaging of neurodegenerative disorders with a focus on multiparametric magnetic resonance and molecular imaging

doi: 10.1186/s13244-022-01358-6

Figure Lengend Snippet: A 76-year-old female with symptomatic left carotid stenosis (70% by North American Symptomatic Carotid Endarterectomy Trial criteria) who presented with right homonymous hemianopia compatible with a left posterior cerebral artery stroke. Arterial spin labeling demonstrates hypoperfusion throughout the left cerebral hemisphere ( a ) and CTA demonstrates a fetal left posterior cerebral artery supplied by the left internal carotid artery ( b ). Florbetaben PET/CT demonstrates no to sparse amyloid plaque ( c ). Flortaucipir PET/CT prior to the event demonstrates no areas of cortical tau retention ( d ). Flortaucipir PET/CT following the event ( e ) demonstrates focal tau retention in the left posterior cerebral artery territory (arrows), likely as a response to cerebral ischemia

Article Snippet: Currently, the most widely used tau selective radiotracer is older-generation F-18 flortaucipir (Tauvid; Avid Radiopharmaceuticals, previously known as AV 1451 and T807) [ ].

Techniques: Labeling, Positron Emission Tomography-Computed Tomography

Journal: Insights into Imaging

Article Title: Multimodality imaging of neurodegenerative disorders with a focus on multiparametric magnetic resonance and molecular imaging

doi: 10.1186/s13244-022-01358-6

Figure Lengend Snippet: A 60-year-old female with cognitive decline (MoCA 19/30) and limb apraxia. Flortaucipir PET/CT ( a ) demonstrates tau retention in the bilateral perirolandic regions (arrow indicating left precentral gyrus). Florbetapir PET/CT ( b ) demonstrates radiotracer activity in the bilateral perirolandic regions (arrow indicating left precentral gyrus). Final diagnosis was CBS secondary to underlying AD, given the abnormal amyloid binding

Article Snippet: Currently, the most widely used tau selective radiotracer is older-generation F-18 flortaucipir (Tauvid; Avid Radiopharmaceuticals, previously known as AV 1451 and T807) [ ].

Techniques: Positron Emission Tomography-Computed Tomography, Activity Assay, Biomarker Discovery, Binding Assay

Journal: Insights into Imaging

Article Title: Multimodality imaging of neurodegenerative disorders with a focus on multiparametric magnetic resonance and molecular imaging

doi: 10.1186/s13244-022-01358-6

Figure Lengend Snippet: A 70-year-old man with history of military combat and traumatic brain injury with MCI, MoCA 26/30. Flortaucipir PET/CT demonstrates regions of tau retention in the sulcal depths of the parasagittal frontal cortices (arrows in a and b ). Tau retention is also noted in the bilateral mesial temporal lobes (arrows in c ). Florbetapir PET/CT ( d ) demonstrates no significant cortical amyloid uptake involving the parietal lobes. Given the findings on PET/CT memory impairment was diagnosed as related to CTE

Article Snippet: Currently, the most widely used tau selective radiotracer is older-generation F-18 flortaucipir (Tauvid; Avid Radiopharmaceuticals, previously known as AV 1451 and T807) [ ].

Techniques: Positron Emission Tomography-Computed Tomography

Journal: Insights into Imaging

Article Title: Multimodality imaging of neurodegenerative disorders with a focus on multiparametric magnetic resonance and molecular imaging

doi: 10.1186/s13244-022-01358-6

Figure Lengend Snippet: A 65-year-old female with reported gradual decline in short term memory and depressive symptoms, initial MoCA 25/30. Florbetapir PET/CT demonstrates normal white matter distribution with no regions of abnormal cortical uptake, compatible with no to sparse amyloid plaque ( a ). Flortaucipir PET/CT demonstrates no cortical tau retention with off-target binding in the bilateral choroid plexuses and basal ganglia ( b ). Score on MoCA improved to 29/30 on antidepressant therapy. Final diagnosis was pseudodementia related to major depressive disorder

Article Snippet: Currently, the most widely used tau selective radiotracer is older-generation F-18 flortaucipir (Tauvid; Avid Radiopharmaceuticals, previously known as AV 1451 and T807) [ ].

Techniques: Positron Emission Tomography-Computed Tomography, Binding Assay, Biomarker Discovery

Journal: Brain and Behavior

Article Title: Frontal variant of Alzheimer's disease with asymmetric presentation mimicking frontotemporal dementia: Case report and literature review

doi: 10.1002/brb3.1548

Figure Lengend Snippet: Regional tracer retention values in molecular imaging of 11 C‐PiB amyloid PET and 18 F‐T807 tau PET

Article Snippet: This pattern was in concordance with molecular neuroimaging topography findings for our patient, for whom 18 F‐T807 tau PET showed increased retention of tau in the right frontal region rather than 11 C‐PiB amyloid PET, and was more correlated with clinical symptoms.

Techniques: Imaging