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C-178（Cat No.:I018134） is a covalent inhibitor of the stimulator of interferon genes (STING). It binds to Cys91 on STING to block its palmitoylation and prevents TBK1 recruitment and Chemicalbook phosphorylation in HEK293T cells. C-178 (0.01-1.25
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Selleck Chemicals
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Noxopharm Ltd
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Nidaria Technology Ltd
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IFM Therapeutics
compounds as covalent inhibitors of sting  Compounds As Covalent Inhibitors Of Sting, supplied by IFM Therapeutics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more https://www.bioz.com/product/sting+inhibitors/compounds+as+covalent+inhibitors+of+sting/pmc07745059-255-22-5 Average 90 stars, based on 1 article reviews
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GlpBio Technology Inc
glpbio c-176 Glpbio C 176, supplied by GlpBio Technology Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more https://www.bioz.com/product/sting+inhibitors/sting+inhibitor+c+176/pmc10846052-65-3-30 Average 90 stars, based on 1 article reviews
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Prantner GmbH
sting specific inhibitor cccp Sting Specific Inhibitor Cccp, supplied by Prantner GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more https://www.bioz.com/product/sting+inhibitors/sting+specific+inhibitor+cccp/pmc06687895-830-10-12 Average 90 stars, based on 1 article reviews
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Pfizer Inc
signal transduction inhibitor include pf 2341066 Signal Transduction Inhibitor Include Pf 2341066, supplied by Pfizer Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more https://www.bioz.com/product/sting+inhibitors/cgas+inc+include+inhibitor+pathway+pfizer+program+sting/us12539304-753-3-8 Average 86 stars, based on 1 article reviews
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InformationC-176 (STING inhibitor) STING inhibitor C-176 is a potent, small-molecule inhibitor of STING , a central signaling component of the intracellular DNA sensing pathway.In vitroC-176 strongly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter
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InformationSTING inhibitor C-178 C-178 is a covalent inhibitor of STING ,covalently bind to Cys91.TargetsSTING
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C-176(CAT: I019711) is a potent covalent inhibitor of mouse STING (stimulator of interferon genes). It strongly inhibits STING-mediated IFNβ reporter activity, specifically targeting the STING pathway and not affecting RIG-I- or TBK1-mediated activities. Treatment with
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Image Search Results
Journal: Acta Pharmaceutica Sinica. B
Article Title: Small molecules targeting the innate immune cGAS‒STING‒TBK1 signaling pathway
doi: 10.1016/j.apsb.2020.03.001
Figure Lengend Snippet: (A) hSTING inhibitors 44 – 46 bearing 1-oxo-tetrahydroisoquinolin-4-yl carboxylic acid fragment; (B) co-crystal structure of human STING in complex with compound 46 (PDB ID: 6MEX), and red dashed lines depict their key interactions.
Article Snippet: Recently, Ablasser and co-workers from
Techniques: