sta-21 Search Results


sta21  (Santa Cruz Biotechnology)
93
Santa Cruz Biotechnology sta21
Effects of STAT3 inhibition on anti-inflammatory activity and migration potential in MSCs from osteoarthritis (OA) patients. (A) OA-MSCs were incubated with <t>STA21</t> for 3 days and, ELISA was performed to measure IL-6, IL-8, IL-1β, and VEGF concentrations. (B) OA-MSCs were incubated with STA21 for 1 h. The expression of phospho (p)-STAT3 705, 727, and total STAT3 protein was analyzed by Western blotting. (C) mRNA levels for anti-inflammatory cytokines IL-10 and TGF-β were measured by real time-PCR (D) Expression of chemokine receptors in OA-MSCs incubated with STA21 was measured by real time-PCR. OA-MSC were isolated of fat tissues obtain from each 3 person with OA. Data represent the mean ± SD of 3 independent experiments ( * P < 0.05; ** p < 0.01).
Sta21, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sta-21/STA-21/pmc06305125-49-34-35
Average 93 stars, based on 1 article reviews
sta21 - by Bioz Stars, 2026-09
93/100 stars
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20mg body weight kg sta 21 mce hy 18061  (MedChemExpress)
92
MedChemExpress 20mg body weight kg sta 21 mce hy 18061
Effects of STAT3 inhibition on anti-inflammatory activity and migration potential in MSCs from osteoarthritis (OA) patients. (A) OA-MSCs were incubated with <t>STA21</t> for 3 days and, ELISA was performed to measure IL-6, IL-8, IL-1β, and VEGF concentrations. (B) OA-MSCs were incubated with STA21 for 1 h. The expression of phospho (p)-STAT3 705, 727, and total STAT3 protein was analyzed by Western blotting. (C) mRNA levels for anti-inflammatory cytokines IL-10 and TGF-β were measured by real time-PCR (D) Expression of chemokine receptors in OA-MSCs incubated with STA21 was measured by real time-PCR. OA-MSC were isolated of fat tissues obtain from each 3 person with OA. Data represent the mean ± SD of 3 independent experiments ( * P < 0.05; ** p < 0.01).
20mg Body Weight Kg Sta 21 Mce Hy 18061, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sta-21/Ochromycinone/pmc09951332__ADVS___10___2206335___s001-186-64-68
Average 92 stars, based on 1 article reviews
20mg body weight kg sta 21 mce hy 18061 - by Bioz Stars, 2026-09
92/100 stars
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sta21  (MedChemExpress)
90
MedChemExpress sta21
Effects of a NF-κB inhibitor on the levels of p-NF-κB and <t>p-STAT3</t> and on the levels of secreted IL-6, IL-8, Rantes and MCP-1 in HcH, MΦ cultures or in HcH/MΦ coculture. ( A ) Effect of a NF-κB inhibitor on the level of p-NF-κB (Western blot) and on the levels (ELISA) of IL-6, IL-8, Rantes, MCP-1 in HcH cultures and the effect of IL-1β treatment. Representative data from one of three experiments are shown; ( B ) Levels of p-STAT3 were determined by Western blotting) and the levels of IL-6 and IL-8 were determined by ELISA assay, in MΦ cultures. Effect of treatment with IL-1β, IL-6, aIL-6 or <t>STA21.</t> Co, control. Representative data from one of three experiments are shown; ( C ) Expression of p-STAT3 (Western blotting) and on the level (ELISA) of IL-6, IL-8, Rantes, MCP-1 in MΦ cocultures. Effect of IL-1β and NF-κB inhibitor. β-Tubulin: protein loading control, Pg/mL: picogram/mL. Representative data from one of three experiments are shown.
Sta21, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sta-21/(%2B)-Ochromycinone/pmc04882693-70-64-69
Average 90 stars, based on 1 article reviews
sta21 - by Bioz Stars, 2026-09
90/100 stars
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sta-21  (Biomol GmbH)
90
Biomol GmbH sta-21
Effects of a NF-κB inhibitor on the levels of p-NF-κB and <t>p-STAT3</t> and on the levels of secreted IL-6, IL-8, Rantes and MCP-1 in HcH, MΦ cultures or in HcH/MΦ coculture. ( A ) Effect of a NF-κB inhibitor on the level of p-NF-κB (Western blot) and on the levels (ELISA) of IL-6, IL-8, Rantes, MCP-1 in HcH cultures and the effect of IL-1β treatment. Representative data from one of three experiments are shown; ( B ) Levels of p-STAT3 were determined by Western blotting) and the levels of IL-6 and IL-8 were determined by ELISA assay, in MΦ cultures. Effect of treatment with IL-1β, IL-6, aIL-6 or <t>STA21.</t> Co, control. Representative data from one of three experiments are shown; ( C ) Expression of p-STAT3 (Western blotting) and on the level (ELISA) of IL-6, IL-8, Rantes, MCP-1 in MΦ cocultures. Effect of IL-1β and NF-κB inhibitor. β-Tubulin: protein loading control, Pg/mL: picogram/mL. Representative data from one of three experiments are shown.
Sta 21, supplied by Biomol GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sta-21/sta+21/pm18025205-76-0-14
Average 90 stars, based on 1 article reviews
sta-21 - by Bioz Stars, 2026-09
90/100 stars
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sta-21, a selective inhibitor of stat3  (Enzo Biochem)
90
Enzo Biochem sta-21, a selective inhibitor of stat3
Effects of a NF-κB inhibitor on the levels of p-NF-κB and <t>p-STAT3</t> and on the levels of secreted IL-6, IL-8, Rantes and MCP-1 in HcH, MΦ cultures or in HcH/MΦ coculture. ( A ) Effect of a NF-κB inhibitor on the level of p-NF-κB (Western blot) and on the levels (ELISA) of IL-6, IL-8, Rantes, MCP-1 in HcH cultures and the effect of IL-1β treatment. Representative data from one of three experiments are shown; ( B ) Levels of p-STAT3 were determined by Western blotting) and the levels of IL-6 and IL-8 were determined by ELISA assay, in MΦ cultures. Effect of treatment with IL-1β, IL-6, aIL-6 or <t>STA21.</t> Co, control. Representative data from one of three experiments are shown; ( C ) Expression of p-STAT3 (Western blotting) and on the level (ELISA) of IL-6, IL-8, Rantes, MCP-1 in MΦ cocultures. Effect of IL-1β and NF-κB inhibitor. β-Tubulin: protein loading control, Pg/mL: picogram/mL. Representative data from one of three experiments are shown.
Sta 21, A Selective Inhibitor Of Stat3, supplied by Enzo Biochem, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sta-21/sta+21/pm23686482-50-5-9
Average 90 stars, based on 1 article reviews
sta-21, a selective inhibitor of stat3 - by Bioz Stars, 2026-09
90/100 stars
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stat3–stat3 dimer antagonists  (Verlag GmbH)
90
Verlag GmbH stat3–stat3 dimer antagonists
Effects of a NF-κB inhibitor on the levels of p-NF-κB and <t>p-STAT3</t> and on the levels of secreted IL-6, IL-8, Rantes and MCP-1 in HcH, MΦ cultures or in HcH/MΦ coculture. ( A ) Effect of a NF-κB inhibitor on the level of p-NF-κB (Western blot) and on the levels (ELISA) of IL-6, IL-8, Rantes, MCP-1 in HcH cultures and the effect of IL-1β treatment. Representative data from one of three experiments are shown; ( B ) Levels of p-STAT3 were determined by Western blotting) and the levels of IL-6 and IL-8 were determined by ELISA assay, in MΦ cultures. Effect of treatment with IL-1β, IL-6, aIL-6 or <t>STA21.</t> Co, control. Representative data from one of three experiments are shown; ( C ) Expression of p-STAT3 (Western blotting) and on the level (ELISA) of IL-6, IL-8, Rantes, MCP-1 in MΦ cocultures. Effect of IL-1β and NF-κB inhibitor. β-Tubulin: protein loading control, Pg/mL: picogram/mL. Representative data from one of three experiments are shown.
Stat3–Stat3 Dimer Antagonists, supplied by Verlag GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sta-21/stat3+specific+inhibitors+jsi124+and+sta21/10__1002_slash_cmdc__201100194-234-15-8
Average 90 stars, based on 1 article reviews
stat3–stat3 dimer antagonists - by Bioz Stars, 2026-09
90/100 stars
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sta21  (Sapphire North America)
90
Sapphire North America sta21
Effects of a NF-κB inhibitor on the levels of p-NF-κB and <t>p-STAT3</t> and on the levels of secreted IL-6, IL-8, Rantes and MCP-1 in HcH, MΦ cultures or in HcH/MΦ coculture. ( A ) Effect of a NF-κB inhibitor on the level of p-NF-κB (Western blot) and on the levels (ELISA) of IL-6, IL-8, Rantes, MCP-1 in HcH cultures and the effect of IL-1β treatment. Representative data from one of three experiments are shown; ( B ) Levels of p-STAT3 were determined by Western blotting) and the levels of IL-6 and IL-8 were determined by ELISA assay, in MΦ cultures. Effect of treatment with IL-1β, IL-6, aIL-6 or <t>STA21.</t> Co, control. Representative data from one of three experiments are shown; ( C ) Expression of p-STAT3 (Western blotting) and on the level (ELISA) of IL-6, IL-8, Rantes, MCP-1 in MΦ cocultures. Effect of IL-1β and NF-κB inhibitor. β-Tubulin: protein loading control, Pg/mL: picogram/mL. Representative data from one of three experiments are shown.
Sta21, supplied by Sapphire North America, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sta-21/sta21/pm31504941-76-10-11
Average 90 stars, based on 1 article reviews
sta21 - by Bioz Stars, 2026-09
90/100 stars
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sta-21-related compounds  (Charlesson)
90
Charlesson sta-21-related compounds
Effects of a NF-κB inhibitor on the levels of p-NF-κB and <t>p-STAT3</t> and on the levels of secreted IL-6, IL-8, Rantes and MCP-1 in HcH, MΦ cultures or in HcH/MΦ coculture. ( A ) Effect of a NF-κB inhibitor on the level of p-NF-κB (Western blot) and on the levels (ELISA) of IL-6, IL-8, Rantes, MCP-1 in HcH cultures and the effect of IL-1β treatment. Representative data from one of three experiments are shown; ( B ) Levels of p-STAT3 were determined by Western blotting) and the levels of IL-6 and IL-8 were determined by ELISA assay, in MΦ cultures. Effect of treatment with IL-1β, IL-6, aIL-6 or <t>STA21.</t> Co, control. Representative data from one of three experiments are shown; ( C ) Expression of p-STAT3 (Western blotting) and on the level (ELISA) of IL-6, IL-8, Rantes, MCP-1 in MΦ cocultures. Effect of IL-1β and NF-κB inhibitor. β-Tubulin: protein loading control, Pg/mL: picogram/mL. Representative data from one of three experiments are shown.
Sta 21 Related Compounds, supplied by Charlesson, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sta-21/sta+21+related+compounds/pm24432979-109-23-15
Average 90 stars, based on 1 article reviews
sta-21-related compounds - by Bioz Stars, 2026-09
90/100 stars
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sta 21  (Cayman Chemical)
N/A
STA 21 is a natural antibiotic that potently inhibits STAT3 by preventing its dimerization and DNA binding when used at concentrations of 20 30 μM It blocks the growth and survival of cancer cells that
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sta-21 (ochromycinone)  (Aladdin Scientific Corporation)
N/A
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
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sta-21  (BOC Sciences)
N/A
STA-21 is a STAT3 inhibitor that reciprocally regulates Th17 and Treg cells, inhibits osteoclastogenesis in mice and humans and alleviates autoimmune inflammation in an experimental model of rheumatoid arthritis.
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Image Search Results


Effects of STAT3 inhibition on anti-inflammatory activity and migration potential in MSCs from osteoarthritis (OA) patients. (A) OA-MSCs were incubated with STA21 for 3 days and, ELISA was performed to measure IL-6, IL-8, IL-1β, and VEGF concentrations. (B) OA-MSCs were incubated with STA21 for 1 h. The expression of phospho (p)-STAT3 705, 727, and total STAT3 protein was analyzed by Western blotting. (C) mRNA levels for anti-inflammatory cytokines IL-10 and TGF-β were measured by real time-PCR (D) Expression of chemokine receptors in OA-MSCs incubated with STA21 was measured by real time-PCR. OA-MSC were isolated of fat tissues obtain from each 3 person with OA. Data represent the mean ± SD of 3 independent experiments ( * P < 0.05; ** p < 0.01).

Journal: Frontiers in Immunology

Article Title: The Therapeutic Effect of STAT3 Signaling-Suppressed MSC on Pain and Articular Cartilage Damage in a Rat Model of Monosodium Iodoacetate-Induced Osteoarthritis

doi: 10.3389/fimmu.2018.02881

Figure Lengend Snippet: Effects of STAT3 inhibition on anti-inflammatory activity and migration potential in MSCs from osteoarthritis (OA) patients. (A) OA-MSCs were incubated with STA21 for 3 days and, ELISA was performed to measure IL-6, IL-8, IL-1β, and VEGF concentrations. (B) OA-MSCs were incubated with STA21 for 1 h. The expression of phospho (p)-STAT3 705, 727, and total STAT3 protein was analyzed by Western blotting. (C) mRNA levels for anti-inflammatory cytokines IL-10 and TGF-β were measured by real time-PCR (D) Expression of chemokine receptors in OA-MSCs incubated with STA21 was measured by real time-PCR. OA-MSC were isolated of fat tissues obtain from each 3 person with OA. Data represent the mean ± SD of 3 independent experiments ( * P < 0.05; ** p < 0.01).

Article Snippet: The cells were cultured for 4 days until 90% confluent (passage 0) and were then expanded for 2–3 passages and used for experiments. iSTAT3 OA-MSCs were prepared by treatment of OA-MSCs with 10 μM STA21 (Santa Cruz, Texas, USA) for 72 h.

Techniques: Inhibition, Activity Assay, Migration, Incubation, Enzyme-linked Immunosorbent Assay, Expressing, Western Blot, Real-time Polymerase Chain Reaction, Isolation

Effects of a NF-κB inhibitor on the levels of p-NF-κB and p-STAT3 and on the levels of secreted IL-6, IL-8, Rantes and MCP-1 in HcH, MΦ cultures or in HcH/MΦ coculture. ( A ) Effect of a NF-κB inhibitor on the level of p-NF-κB (Western blot) and on the levels (ELISA) of IL-6, IL-8, Rantes, MCP-1 in HcH cultures and the effect of IL-1β treatment. Representative data from one of three experiments are shown; ( B ) Levels of p-STAT3 were determined by Western blotting) and the levels of IL-6 and IL-8 were determined by ELISA assay, in MΦ cultures. Effect of treatment with IL-1β, IL-6, aIL-6 or STA21. Co, control. Representative data from one of three experiments are shown; ( C ) Expression of p-STAT3 (Western blotting) and on the level (ELISA) of IL-6, IL-8, Rantes, MCP-1 in MΦ cocultures. Effect of IL-1β and NF-κB inhibitor. β-Tubulin: protein loading control, Pg/mL: picogram/mL. Representative data from one of three experiments are shown.

Journal: Nutrients

Article Title: Resveratrol Interferes with IL1-β-Induced Pro-Inflammatory Paracrine Interaction between Primary Chondrocytes and Macrophages

doi: 10.3390/nu8050280

Figure Lengend Snippet: Effects of a NF-κB inhibitor on the levels of p-NF-κB and p-STAT3 and on the levels of secreted IL-6, IL-8, Rantes and MCP-1 in HcH, MΦ cultures or in HcH/MΦ coculture. ( A ) Effect of a NF-κB inhibitor on the level of p-NF-κB (Western blot) and on the levels (ELISA) of IL-6, IL-8, Rantes, MCP-1 in HcH cultures and the effect of IL-1β treatment. Representative data from one of three experiments are shown; ( B ) Levels of p-STAT3 were determined by Western blotting) and the levels of IL-6 and IL-8 were determined by ELISA assay, in MΦ cultures. Effect of treatment with IL-1β, IL-6, aIL-6 or STA21. Co, control. Representative data from one of three experiments are shown; ( C ) Expression of p-STAT3 (Western blotting) and on the level (ELISA) of IL-6, IL-8, Rantes, MCP-1 in MΦ cocultures. Effect of IL-1β and NF-κB inhibitor. β-Tubulin: protein loading control, Pg/mL: picogram/mL. Representative data from one of three experiments are shown.

Article Snippet: The crucial role of IL-6 in our model was evaluated by using anti-IL-6 (from Merck Chimie SAS 201, Rue Carnot, Fontenay sous Bois, Île-de-France 94126, France), p65 antibody S536 (anti p-NF-κB) and Y705 (anti p-STAT3 antibody) (from Abcam, 24 rue Louis Blanc, 75010 PARIS, France), the NF-κB phosphorylation inhibitors (BAY-11-7082) (from Merck Chimie SAS, 201, Rue Carnot, Fontenay sous Bois, Île-de-France 94126, France), and STA21 (STAT3 phosphorylation inhibitor) (from Medchemexpress Europe Box 128-521-1298 Stockholm, Sweden).

Techniques: Western Blot, Enzyme-linked Immunosorbent Assay, Control, Expressing