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SR 202 is a selective PPARγ antagonist used as an antidiabetic and antiobesity agent. SR 202 inhibits PPARγ-dependent adipocyte differentiation and growth in vitro and in vivo, improves insulin sensitivity in diabetic ob/ob mice and
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Image Search Results
Journal: Aging (Albany NY)
Article Title: Impact of cytotoxic agents or apoptosis stimulants on αklotho in MDCK, NRK-52E and HK2 kidney cells
doi: 10.18632/aging.204238
Figure Lengend Snippet: Selective PPARγ antagonist SR-202 blunts cisplatin-dependent αklotho gene expression in MDCK cells. Arithmetic mean ± SEM of αklotho transcripts relative to TBP in MDCK cells treated with 3 μM cisplatin or vehicle control in the absence (left bars) or presence (right bars) of 200 μM PPARγ antagonist SR-202 for 24 h ( n = 8, repeated measures ANOVA followed by Dunnett post hoc test). ** p < 0.01 indicates significant difference from vehicle control (1 st bar vs. 2 nd bar), # indicates significant difference from the absence of PPARγ inhibitor SR-202 (2 nd bar vs. 4 th bar); Abbreviations: a. u.: arbitrary units; ctr: control.
Article Snippet:
Techniques: Expressing