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Proteintech
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GeneTex
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Image Search Results
Journal: Discover. Oncology
Article Title: SPI1 is a prognostic biomarker of immune infiltration and immunotherapy efficacy in clear cell renal cell carcinoma.
doi: 10.1007/s12672-022-00592-0
Figure Lengend Snippet: Fig. 1 SPI1 expression in ccRCC. a, b SPI1 protein and mRNA expression levels were elevated in ccRCC bulk tissues compared to normal bulk tissues in the UALCAN database. c SPI1protein expression levels in six pairs ccRCC tumor bulk tissues and adjacent normal bulk tissues as well as ccRCC cell lines. d SPI1 mRNA expression levels in eight ccRCC tumor bulk tissues and adjacent normal bulk tissues (e) SPI1 protein expression levels was elevated in ccRCC stroma compared to normal stroma in our cohort. ccRCC, clear cell renal cell carcinoma; *, p < 0.05; **, p < 0.01; ***, p < 0.001
Article Snippet:
Techniques: Expressing
Journal: Discover. Oncology
Article Title: SPI1 is a prognostic biomarker of immune infiltration and immunotherapy efficacy in clear cell renal cell carcinoma.
doi: 10.1007/s12672-022-00592-0
Figure Lengend Snippet: Fig. 2 Relationship between SPI1 expression and clinicopathological parameters in ccRCC. a Clinicopathological parameters correlated with SPI1 expression. b–e High SPI1 expression level was associated with high Furman grade (b), T stage (c), positive nodal status (d), and metas- tasis status (e). ccRCC, clear cell renal cell carcinoma; *, p < 0.05; **, p < 0.01; ***, p < 0.001
Article Snippet:
Techniques: Expressing
Journal: Discover. Oncology
Article Title: SPI1 is a prognostic biomarker of immune infiltration and immunotherapy efficacy in clear cell renal cell carcinoma.
doi: 10.1007/s12672-022-00592-0
Figure Lengend Snippet: Fig. 3 Prognostic value of SPI1. a, b High SPI1 expression level predicted poor OS (a) and PFS b in ccRCC. c, d OS (c) and PFS (d) predictions of patients with ccRCC at five years after surgery are shown in nomograms. e, f Calibration plots of the nomograms for the prediction of five- year OS e and PFS f. ccRCC clear cell renal cell carcinoma; OS overall survival; PFS progression-free survival
Article Snippet:
Techniques: Expressing
Journal: Discover. Oncology
Article Title: SPI1 is a prognostic biomarker of immune infiltration and immunotherapy efficacy in clear cell renal cell carcinoma.
doi: 10.1007/s12672-022-00592-0
Figure Lengend Snippet: Fig. 4 Relationship between SPI1 expression and CD68 + macrophages, CD4 + T cells, and CD8 + T cells infiltration. a SPI1 expression correlated posi- tively with CD68 + macrophages, CD4 + T cells, and CD8 + T cells infiltration in our cohort. b SPI1, CD68 + , CD8 + , and CD4 + expression levels in the same patients are shown by IHC. ccRCC, clear cell renal cell carcinoma; *, p < 0.05; **, p < 0.01; ***, p < 0.001; IHC, immunohistochemistry
Article Snippet:
Techniques: Expressing, Immunohistochemistry
Journal: Discover. Oncology
Article Title: SPI1 is a prognostic biomarker of immune infiltration and immunotherapy efficacy in clear cell renal cell carcinoma.
doi: 10.1007/s12672-022-00592-0
Figure Lengend Snippet: Fig. 5 Relationship between SPI1 expression and immunotherapy efficacy. a SPI1 expression in three responders receiving immunotherapy. b SPI1 expression in four non-responders receiving immunotherapy. Responders included patients with complete disease and partial dis- ease, and non-responders included patients with progressive disease and stable disease
Article Snippet:
Techniques: Expressing
Journal: Discover. Oncology
Article Title: SPI1 is a prognostic biomarker of immune infiltration and immunotherapy efficacy in clear cell renal cell carcinoma.
doi: 10.1007/s12672-022-00592-0
Figure Lengend Snippet: Fig. 6 Genes coexpressed with SPI1 in KIRC using the LinkedOmics database. a, b The top 50 genes positively and negatively associated with SPI1 shown in the heat maps. Blue represents negatively linked genes and red represents positively linked genes. c, d Gene Ontology annotations c and Kyoto Encyclopedia of Genes and Genomes pathways (d) of SPI1 in KIRC cohort. KIRC, kidney renal clear cell carcinoma
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